公开(公告)号：US20070167485A1

公开(公告)日：2007-07-19

申请号：US10598944

申请日：2005-03-15

Applicant: Diane Coe ,  Caroline Cook ,  Anthony Cooper ,  Christopher Edlin ,  Julie Hamblin ,  Martin Johnson ,  Paul Jones ,  Mika Lindvall ,  Charlotte Mitchell ,  Alison Redgrave ,  John Robinson

Inventor： Diane Coe ,  Caroline Cook ,  Anthony Cooper ,  Christopher Edlin ,  Julie Hamblin ,  Martin Johnson ,  Paul Jones ,  Mika Lindvall ,  Charlotte Mitchell ,  Alison Redgrave ,  John Robinson

IPC: A61K31/44

CPC classification number: C07D471/04

Abstract: The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is Et, n-Pr, i-Pr, C2fluoroalkyl, or —CH2CH2OH; R2 is H, Me, Et, n-Pr, i-Pr, C1-2fluoroalkyl, cyclopropyl or (cyclopropyl)methyl-; and NHR3 has the sub-formula (nhr3): wherein R3a is methyl or ethyl; R3b is H, methyl or ethyl; R3c is H, methyl or ethyl, R3d is H, methyl or ethyl, and R3e is H or methyl, provided that: (a) R3b is methyl or ethyl; and/or (b) R3c and R3d are independently methyl or ethyl; and provided that: (c) when R3c is ethyl and/or when R3d is ethyl and/or when R3e is methyl, then: R3a is methyl and/or R3b is hydrogen or methyl. These compounds are PDE4 inhibitors.

Abstract translation: 本发明涉及式（I）化合物或其盐：其中：R 1是Et，n-Pr，i-Pr，C 2氟代烷基，或 -CH 2 CH 2 CH 2 OH; R 2是H，Me，Et，n-Pr，i-Pr，C 1-12氟代烷基，环丙基或（环丙基）甲基; 和NHR 3具有子式（nhr3）：其中R 3a是甲基或乙基; R 3b是H，甲基或乙基; R 3c是H，甲基或乙基，R 3d是H，甲基或乙基，R 3e是H或甲基，条件是： （a）R 3b是甲基或乙基; 和/或（b）R 3c和R 3d独立地是甲基或乙基; 并且条件是：（c）当R 3c为乙基时，和/或当R 3d为乙基时，和/或当R 3e为甲基时， 那么：R 3a是甲基，和/或R 3b是氢或甲基。 这些化合物是PDE4抑制剂。