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公开(公告)号：US20110311653A1
公开(公告)日：2011-12-22
申请号：US12741436
申请日：2008-11-17
申请人： Christopher Kevil , David Lefer , Rakesh Patel
发明人： Christopher Kevil , David Lefer , Rakesh Patel
摘要： Methods of treating a subject who has chronic tissue ischemia are disclosed. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to result in blood vessel growth in the ischemic tissue. The subject can be diagnosed as having a medical condition that results in persistent or recurring restriction of blood supply to a tissue, for example, peripheral artery disease, diabetes, atherosclerotic cardiovascular disease or defective wound healing. The methods can include the step of identifying a suitable subject.
摘要翻译： 公开了治疗患有慢性组织缺血的受试者的方法。 所述方法可以包括给受试者施用包含无机亚硝酸盐或其药学上可接受的盐的药物组合物，其时间和量足以导致缺血组织中的血管生长。 该受试者可以被诊断为具有导致对组织的血液供应的持续或重复限制的医学病症，例如外周动脉疾病，糖尿病，动脉粥样硬化心血管疾病或伤口愈合不良。 所述方法可以包括鉴定合适的受试者的步骤。
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公开(公告)号：US20110086069A1
公开(公告)日：2011-04-14
申请号：US12904791
申请日：2010-10-14
CPC分类号： A61K33/00 , A61K9/0053 , A61K9/2068 , A61K9/2866 , A61K9/5042
摘要： The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (NO2−). The pharmaceutical compositions of the invention are useful, for example, for the treatment of chronic tissue ischemia.
摘要翻译： 本发明涉及亚硝酸盐如无机亚硝酸盐的药物组合物或其任何药学上可接受的盐，溶剂合物或前药，以及这些组合物的医疗用途。 可以配制用于口服给药的药物组合物可以提供亚硝酸根离子（NO2-）的即时释放或延长释放。 本发明的药物组合物可用于例如治疗慢性组织缺血。
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