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    USE OF NITRITE SALTS IN TREATING TISSUE DAMAGE
    3.
    发明申请
    USE OF NITRITE SALTS IN TREATING TISSUE DAMAGE 审中-公开
    使用硝酸盐处理组织损伤

    公开(公告)号：US20120237617A1

    公开(公告)日：2012-09-20

    申请号：US13378530

    申请日：2010-05-26

    申请人： Christopher Kevil

    发明人： Christopher Kevil

    IPC分类号： A61K33/00 ,  A61P29/00 ,  A61P43/00 ,  A61P17/00 ,  A61P9/00 ,  A61P3/10 ,  A61P9/10 ,  A61P1/00 ,  A61P19/08 ,  A61P25/02 ,  A61P31/00 ,  A61P19/02 ,  A61P31/04 ,  A61P31/10 ,  A61K33/06

    CPC分类号： A61K33/00 ,  A61K33/06 ,  A61K38/18 ,  A61K45/06

    摘要： Methods of treating a subject who has an tissue damage or who is at risk for tissue necrosis are disclosed. Also disclosed are methods of treating a subject who has an inflammatory disorder. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to reduce the tissue damage. The subject can be diagnosed as having a medical condition that results tissue damage, for example, diabetes, peripheral artery disease, cardiovascular disease, defective wound healing, arthritis, inflammatory bowel disease, ischemia, or a bacterial infection, e.g., Group A staphylococcal infection. The methods can include the step of monitoring the course of treatment.

    摘要翻译： 公开了治疗组织损伤或组织坏死风险的受试者的方法。 还公开了治疗患有炎性障碍的受试者的方法。 所述方法可以包括向受试者施用包含无机亚硝酸盐或其药学上可接受的盐的药物组合物，其时间和量足以减少组织损伤。 可以将该受试者诊断为具有导致组织损伤的医学病症，例如糖尿病，外周动脉疾病，心血管疾病，伤口愈合不良，关节炎，炎性肠病，缺血或细菌感染，例如A组葡萄球菌感染 。 这些方法可以包括监测治疗过程的步骤。

    Use of nitrite salts in chronic ischemia
    7.
    发明授权
    Use of nitrite salts in chronic ischemia 有权

    公开(公告)号：US09649334B2

    公开(公告)日：2017-05-16

    申请号：US12741436

    申请日：2008-11-17

    申请人： Christopher Kevil ,  David Lefer ,  Rakesh Patel

    发明人： Christopher Kevil ,  David Lefer ,  Rakesh Patel

    IPC分类号： A61K33/06 ,  A61K33/00 ,  A61K45/06

    CPC分类号： A61K33/06 ,  A61K33/00 ,  A61K45/06

    摘要： Methods of treating a subject who has chronic tissue ischemia are disclosed. The methods can include administering to the subject a pharmaceutical composition comprising inorganic nitrite or a pharmaceutically acceptable salt thereof, for a time and in an amount sufficient to result in blood vessel growth in the ischemic tissue. The subject can be diagnosed as having a medical condition that results in persistent or recurring restriction of blood supply to a tissue, for example, peripheral artery disease, diabetes, atherosclerotic cardiovascular disease or defective wound healing. The methods can include the step of identifying a suitable subject.