公开(公告)号：US4560750A

公开(公告)日：1985-12-24

申请号：US367016

申请日：1982-04-09

申请人： Kunio Atsumi ,  Kiyoaki Katano ,  Fumio Kai ,  Ken Nishihata ,  Eiichi Akita

发明人： Kunio Atsumi ,  Kiyoaki Katano ,  Fumio Kai ,  Ken Nishihata ,  Eiichi Akita

IPC分类号： C07D501/16 ,  A61K20060101 ,  A61K31/545 ,  C07D501/04 ,  C07D501/18 ,  C07D501/57

CPC分类号： C07D501/57 ,  Y02P20/55

摘要： Disclosed is a novel cephem compound represented by the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Y are as defined in the specification, which is a useful intermediate for synthesizing various cephalosporin antibiotics having a methoxy group at the 7.alpha.-position thereof. Also disclosed is a process for preparing the same.

摘要翻译： 公开了由下式表示的新型头孢烯化合物：其中R 1，R 2，R 3，R 4和Y如说明书中所定义，其是用于合成具有在7α-甲基的甲氧基的各种头孢菌素抗生素的有用中间体， 的位置。 还公开了其制备方法。

公开(公告)号：US4169890A

公开(公告)日：1979-10-02

申请号：US800857

申请日：1977-05-26

申请人： Takeo Miyazawa ,  Yukio Horiuchi ,  Eiichi Akita ,  Hamao Umezawa ,  Sumio Umezawa

发明人： Takeo Miyazawa ,  Yukio Horiuchi ,  Eiichi Akita ,  Hamao Umezawa ,  Sumio Umezawa

IPC分类号： C07H15/23 ,  A61K31/71 ,  C07H15/22

CPC分类号： C07H15/23

摘要： A process for preparing a novel antibiotic, 5"-amino-3',5"-dideoxy-ribostamycin, which comprises subjecting a ribostamycin derivative represented by the formula: ##STR1## to selective sulfonylation to form a 3',5"-O-disulfonyl derivative, SUBJECTING THE THUS PRODUCED DERIVATIVE TO AZIDE-FORMING REACTION WITH SODIUM AZIDE,Subjecting the thus produced ribostamycin 3'-O-sulfonyl-5"-azido derivative to deoxylation by treating it with sodium borohydride in an aprotic and polar solvent,Subjecting the thus obtained 3' deoxy derivative to catalytic hydrogenation in the presence of a catalyst to form a 5"-amino derivativeAnd then, removing the remaining protective groups of the last-mentioned derivative.

公开(公告)号：US4078138A

公开(公告)日：1978-03-07

申请号：US638045

申请日：1975-12-05

申请人： Eiichi Akita ,  Yukio Horiuchi ,  Takeo Miyazawa ,  Toshio Yoneta ,  Sumio Umezawa ,  Hamao Umezawa

发明人： Eiichi Akita ,  Yukio Horiuchi ,  Takeo Miyazawa ,  Toshio Yoneta ,  Sumio Umezawa ,  Hamao Umezawa

IPC分类号： A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/7036 ,  A61K31/704 ,  A61P31/04 ,  C07H15/224 ,  C07H15/23 ,  C07H15/234 ,  C07H15/236 ,  C07H15/244 ,  C07H15/22

CPC分类号： C07H15/224 ,  C07H15/23 ,  C07H15/234

摘要： 3',4'-.alpha.-Epoxyneamine and its related aminoglycosidic antibiotic derivatives containing 3',4'-.alpha.-epoxyneamine moiety in the molecule thereof are now provided, which may be in the form of their amino-protected and partially hydroxyl-protected product and which are useful as intermediates for use in the synthetic production of therapeutically valuable 3'-deoxy derivatives of aminoglycosidic antibiotics.

摘要翻译： 现在提供了分子中含有3'，4'-α-环氧基胺部分的3'，4'-α-氧苯胺及其相关的氨基糖苷类抗生素衍生物，其可以是其氨基保护和部分羟基保护的形式 并且其可用作用于合成生产氨基糖苷类抗生素治疗有价值的3'-脱氧衍生物的中间体。