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11.发明授权公开(公告)号：US08859583B2
公开(公告)日：2014-10-14
申请号：US13275786
申请日：2011-10-18
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
IPC: A01N43/42 , A61K31/44 , C07D513/02 , C07D515/02 , C07D487/04 , C07D471/04
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，A，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和所述化合物在 疾病的治疗，例如 癌症。
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12.发明授权公开(公告)号：US08796244B2
公开(公告)日：2014-08-05
申请号：US12997754
申请日：2009-06-12
Applicant: Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud , Marian Williams
Inventor： Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
IPC: A61K31/5025 , C07D413/02
CPC classification number: C07D471/04 , C07D513/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及新的双环杂环衍生物化合物，包含该化合物的药物组合物和该化合物在治疗疾病中的用途。 癌症。
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13.发明申请公开(公告)号：US20120035153A1
公开(公告)日：2012-02-09
申请号：US13275786
申请日：2011-10-18
Applicant: Gordon SAXTY , Valerio BERDINI , Christopher William MURRAY , Charlotte Mary GRIFFITHS-JONES , Emma VICKERSTAFFE , Gilbert Ebai BESONG , Maria Grazia CARR
Inventor： Gordon SAXTY , Valerio BERDINI , Christopher William MURRAY , Charlotte Mary GRIFFITHS-JONES , Emma VICKERSTAFFE , Gilbert Ebai BESONG , Maria Grazia CARR
IPC: A61K31/519 , A61P35/00 , C07D487/04 , C07D471/04 , A61K31/437
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，A，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和所述化合物在 疾病的治疗，例如 癌症。
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14.发明申请公开(公告)号：US20100286113A1
公开(公告)日：2010-11-11
申请号：US12682478
申请日：2008-10-10
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
IPC: A61K31/437 , C07D471/04 , C07D487/04 , A61P35/00
CPC classification number: C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, q, A, B, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，q，A，B，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和使用 的所述化合物治疗疾病，例如 癌症。
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