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1.发明授权公开(公告)号：US08859582B2
公开(公告)日：2014-10-14
申请号：US13275752
申请日：2011-10-18
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
IPC: A01N43/42 , A61K31/44 , C07D513/02 , C07D515/02 , C07D471/04
CPC classification number: C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, q, A, B, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，q，A，B，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和使用 的所述化合物治疗疾病，例如 癌症。
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2.发明申请公开(公告)号：US20120208791A1
公开(公告)日：2012-08-16
申请号：US12997754
申请日：2009-06-12
Applicant: Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Marian Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
Inventor： Valerio Berdini , Maria Grazia Carr , Miles Stuart Congreve , Martyn Frederickson , Charlotte Mary Griffiths-Jones , Christopher Charles Frederick Hamlett , Andrew Madin , Christopher William Murray , Rajdeep Kaur Benning , Gordon Saxty , Emma Vickerstaffe , Brian John Williams , Marian Williams , Andrew James Woodhead , Steven John Woodhead , Eddy Jean Edgard Freyne , Tom Cornelis Hortense Govaerts , Patrick René Angibaud
IPC: A61K31/437 , A61K31/501 , A61P35/00 , C07D513/04 , A61K31/53 , A61K31/506 , C07D471/04 , A61K31/5377
CPC classification number: C07D471/04 , C07D513/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及新的双环杂环衍生物化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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3.发明申请公开(公告)号：US20120035152A1
公开(公告)日：2012-02-09
申请号：US13275752
申请日：2011-10-18
Applicant: Gordon SAXTY , Valerio BERDINI , Christopher William MURRAY , Charlotte Mary GRIFFITHS-JONES , Emma VICKERSTAFFE , Gilbert Ebai BESONG
Inventor： Gordon SAXTY , Valerio BERDINI , Christopher William MURRAY , Charlotte Mary GRIFFITHS-JONES , Emma VICKERSTAFFE , Gilbert Ebai BESONG
IPC: A61K31/437 , A61P35/00 , A61K31/519
CPC classification number: C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, q, A, B, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，q，A，B，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和使用 的所述化合物治疗疾病，例如 癌症。
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4.发明申请公开(公告)号：US20100331296A1
公开(公告)日：2010-12-30
申请号：US12682508
申请日：2008-10-10
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
IPC: A61K31/437 , C07D471/04 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，A，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和所述化合物在 疾病的治疗，例如 癌症。
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![Imidazo[1,2-a]pyridine compounds for use in treating cancer](/abs-image/US/2013/08/20/US08513276B2/abs.jpg.150x150.jpg)
公开(公告)号：US08513276B2
公开(公告)日：2013-08-20
申请号：US12520333
申请日：2007-12-21
Applicant: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
Inventor： Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC: C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物，包含所述化合物的药物组合物以及所述化合物在治疗疾病中的用途。 癌症。 式（I）的化合物是FGFR，VEGFR或PDGFR的抑制剂。
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Patent Agency Ranking
公开(公告)号：US20100120761A1
公开(公告)日：2010-05-13
申请号：US12520481
申请日：2007-12-21
Applicant: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , MIles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
Inventor： Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , MIles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC: A61K31/437 , C07D471/04 , C07D487/04 , A61K31/496 , A61K31/5377 , A61K31/519 , A61P35/00
CPC classification number: C07D487/04 , A61K31/437 , C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及新的双环杂环衍生物化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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公开(公告)号：US20100093718A1
公开(公告)日：2010-04-15
申请号：US12520333
申请日：2007-12-21
Applicant: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
Inventor： Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC: A61K31/5377 , C07D401/14 , A61K31/496 , C07D413/14 , C07D471/02 , A61K31/437 , C07D487/02 , A61K31/519 , A61P35/00
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of Formula (I), to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer The compounds of Formula (I) are inhibitors of FGFR, VEGFR or PDGFR.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物，包含所述化合物的药物组合物以及所述化合物在治疗疾病中的用途。 癌症化学式（I）的化合物是FGFR，VEGFR或PDGFR的抑制剂。
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公开(公告)号：US08895745B2
公开(公告)日：2014-11-25
申请号：US12520481
申请日：2007-12-21
Applicant: Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
Inventor： Valerio Berdini , Gilbert Ebai Besong , Owen Callaghan , Maria Grazia Carr , Miles Stuart Congreve , Adrian Liam Gill , Charlotte Mary Griffiths-Jones , Andrew Madin , Christopher William Murray , Rajdeep Kaur Nijjar , Michael Alistair O'Brien , Andrew Pike , Gordon Saxty , Richard David Taylor , Emma Vickerstaffe
IPC: C07D471/04 , A61K31/437 , C07D487/04
CPC classification number: C07D487/04 , A61K31/437 , C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及新的双环杂环衍生物化合物，包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。 癌症。
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9.发明授权公开(公告)号：US08076354B2
公开(公告)日：2011-12-13
申请号：US12682508
申请日：2008-10-10
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong , Maria Grazia Carr
IPC: A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02
CPC classification number: C07D471/04 , C07D487/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, A, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，A，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和所述化合物在 疾病的治疗，例如 癌症。
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10.发明授权公开(公告)号：US08071614B2
公开(公告)日：2011-12-06
申请号：US12682478
申请日：2008-10-10
Applicant: Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
Inventor： Gordon Saxty , Valerio Berdini , Christopher William Murray , Charlotte Mary Griffiths-Jones , Emma Vickerstaffe , Gilbert Ebai Besong
IPC: A01N43/42 , A61K31/44 , C07D491/02 , C07D498/02
CPC classification number: C07D471/04
Abstract: The invention relates to new bicyclic heterocyclic derivative compounds of formula (I): wherein R1, q, A, B, X1, X2, X3, X4, X5 and R2 are as defined herein, to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
Abstract translation: 本发明涉及式（I）的新的双环杂环衍生物化合物：其中R1，q，A，B，X1，X2，X3，X4，X5和R2如本文所定义，包含所述化合物的药物组合物和使用 的所述化合物治疗疾病，例如 癌症。
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