公开(公告)号：US08377974B2

公开(公告)日：2013-02-19

申请号：US13213927

申请日：2011-08-19

Applicant: Bing-Yan Zhu ,  Shawn M. Bauer ,  Zhaozhong J. Jia ,  Gary D. Probst ,  Yanchen Zhang

Inventor： Bing-Yan Zhu ,  Shawn M. Bauer ,  Zhaozhong J. Jia ,  Gary D. Probst ,  Yanchen Zhang ,  Robert M. Scarborough

IPC: A61K31/4025 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/4192 ,  A61K31/4196 ,  C07D233/64 ,  C07D231/12 ,  C07D207/34

CPC classification number: C07D413/14 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

公开(公告)号：US20120178733A1

公开(公告)日：2012-07-12

申请号：US13213927

申请日：2011-08-19

Applicant: Bing-Yan Zhu ,  Shawn M. Bauer ,  Zhaozhong J. Jia ,  Gary D. Probst ,  Yanchen Zhang ,  Robert M. Scarborough

Inventor： Bing-Yan Zhu ,  Shawn M. Bauer ,  Zhaozhong J. Jia ,  Gary D. Probst ,  Yanchen Zhang ,  Robert M. Scarborough

IPC: A61K31/422 ,  C07D413/14 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/506 ,  C07D417/14 ,  A61K31/541 ,  A61K31/553 ,  A61K31/551 ,  C07D409/14 ,  C07D409/12 ,  A61K31/4192 ,  C07D417/12 ,  A61K31/427 ,  A61K31/4178 ,  A61K31/4709 ,  A61P9/00 ,  A61P9/10 ,  A01N1/02 ,  A61P7/02 ,  C07D413/12

CPC classification number: C07D413/14 ,  C07D333/38 ,  C07D409/12 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.

Abstract translation: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐，溶剂合物，水合物和前药。 本发明还涉及用于制备这种化合物的中间体，含有这些化合物的药物组合物，预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。