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公开(公告)号:US08153670B2
公开(公告)日:2012-04-10
申请号:US12348879
申请日:2009-01-05
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/415 , A61K31/4164 , A61K31/4192 , C07D249/04 , C07D233/66 , C07D207/34
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号:US08377974B2
公开(公告)日:2013-02-19
申请号:US13213927
申请日:2011-08-19
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/4025 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , C07D233/64 , C07D231/12 , C07D207/34
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
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公开(公告)号:US20120178733A1
公开(公告)日:2012-07-12
申请号:US13213927
申请日:2011-08-19
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/422 , C07D413/14 , A61K31/454 , A61K31/5377 , A61K31/55 , A61K31/4545 , A61K31/4439 , A61K31/496 , A61K31/506 , C07D417/14 , A61K31/541 , A61K31/553 , A61K31/551 , C07D409/14 , C07D409/12 , A61K31/4192 , C07D417/12 , A61K31/427 , A61K31/4178 , A61K31/4709 , A61P9/00 , A61P9/10 , A01N1/02 , A61P7/02 , C07D413/12
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号:US20090298806A1
公开(公告)日:2009-12-03
申请号:US12348879
申请日:2009-01-05
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/422 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/454 , A61K31/55 , A61K31/5377 , A61K31/4439 , A61K31/496 , A61K31/506 , A61K31/541 , A61K31/553 , A61P9/00
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号:US20100234352A1
公开(公告)日:2010-09-16
申请号:US12697135
申请日:2010-01-29
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/55 , A61K31/497 , A61K31/513 , A61K31/501 , A61K31/551 , A61K31/4192 , A61K31/4439 , A61K31/444 , A61K31/4178 , A61K31/454 , A61K31/4545 , A61K31/5377 , A61K31/538 , A61K31/4709 , A61P7/02 , A61P9/00
CPC分类号: C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式(I)表示的化合物或其药学上可接受的盐,酯或前药,其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号:US07696352B2
公开(公告)日:2010-04-13
申请号:US11620615
申请日:2007-01-05
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough , Carroll Anna Crew Scarborough, legal representative
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Yonghong Song , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: C07D409/14 , C07D401/14 , C07D409/12 , A61K31/4436
CPC分类号: C07D409/14 , C07D333/38 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula (I) or a pharmaceutically acceptable salt, ester, or prodrug thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式(I)表示的化合物或其药学上可接受的盐,酯或前药,其是因子Xa的抑制剂。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号:US07521470B2
公开(公告)日:2009-04-21
申请号:US11158274
申请日:2005-06-20
申请人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
发明人: Bing-Yan Zhu , Shawn M. Bauer , Zhaozhong J. Jia , Gary D. Probst , Yanchen Zhang , Robert M. Scarborough
IPC分类号: A61K31/415 , A61K31/4164 , A61K31/4192 , C07D249/04 , C07D233/66 , C07D207/34
CPC分类号: C07D413/14 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14
摘要: The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The present invention is also directed to and intermediates used in making such compounds, pharmaceutical compositions containing such compounds, methods to prevent or treat a number of conditions characterized by undesired thrombosis and methods of inhibiting the coagulation of a blood sample.
摘要翻译: 本发明涉及由式I表示的化合物及其作为因子Xa抑制剂的药学上可接受的盐,溶剂合物,水合物和前药。 本发明还涉及用于制备这种化合物的中间体,含有这些化合物的药物组合物,预防或治疗多种不想要的血栓形成特征的病症的方法以及抑制血液样品凝固的方法。
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公开(公告)号:US20120142671A1
公开(公告)日:2012-06-07
申请号:US13287005
申请日:2011-11-01
申请人: Zhaozhong J. Jia , Yonghong Song , Qing Xu , Brian Kane , Shawn M. Bauer , Anjali Pandey
发明人: Zhaozhong J. Jia , Yonghong Song , Qing Xu , Brian Kane , Shawn M. Bauer , Anjali Pandey
IPC分类号: A61K31/166 , C07D209/08 , A61K31/404 , C07D249/06 , A61K31/4192 , C07D275/03 , A61K31/425 , C07D417/12 , A61K31/4439 , C07D413/12 , A61K31/5377 , A61K31/55 , A61P9/00 , A61P29/00 , A61P37/00 , A61P7/04 , A61P7/06 , A61P9/10 , A61P37/08 , A61P11/06 , A61P35/00 , A61P1/00 , A61P3/00 , A61P19/04 , A61P17/06 , A61P25/00 , A61P35/02 , C12N9/99 , C12N5/02 , C07C237/30
CPC分类号: C07C237/42 , C07C237/30 , C07C2601/14 , C07D209/08 , C07D209/40 , C07D213/74 , C07D213/82 , C07D231/12 , C07D231/38 , C07D233/56 , C07D239/48 , C07D249/06 , C07D249/08 , C07D257/04 , C07D261/14 , C07D275/03 , C07D277/42 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D495/04
摘要: The present invention is directed to compounds of formula I and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of Syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition Syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by Syk kinase activity, such as Non Hodgkin's Lymphoma.
摘要翻译: 本发明涉及作为Syk激酶抑制剂的式I化合物及其药学上可接受的盐,酯和前药。 本发明还涉及用于制备这些化合物的中间体,这种化合物的制备,含有这种化合物的药物组合物,抑制Syk激酶活性的方法,抑制血小板聚集的方法,以及预防或治疗数字的方法 的条件至少部分地由Syk激酶活性介导,例如非霍奇金淋巴瘤。
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公开(公告)号:US08063058B2
公开(公告)日:2011-11-22
申请号:US12386525
申请日:2009-04-16
申请人: Zhaozhong J. Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
发明人: Zhaozhong J. Jia , Chandrasekar Venkataramani , Wolin Huang , Mukund Mehrotra , Yonghong Song , Qing Xu , Shawn M. Bauer , Jack W. Rose , Brian Kane , Anjali Pandey
IPC分类号: A01N43/54 , A61K31/505 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号: A61K31/506 , C07D239/48 , C07D401/12 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
摘要: The present invention is directed to compounds of formula I-V and tautomers thereof or pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要翻译: 本发明涉及作为syk激酶抑制剂的式I-V化合物及其互变异构体或其药学上可接受的盐,酯和前体药物。 本发明还涉及用于制备这种化合物的中间体,这种化合物的制备,含有这种化合物的药物组合物,抑制syk激酶活性的方法,抑制血小板聚集的方法,以及预防或治疗数字的方法 至少部分通过syk激酶活性介导的病症,例如不期望的血栓形成和非霍奇金淋巴瘤。
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公开(公告)号:US20130029944A1
公开(公告)日:2013-01-31
申请号:US13528709
申请日:2012-06-20
申请人: Yonghong Song , Qing Xu , Shawn M. Bauer , Zhaozhong J. Jia , Mukund Mehrotra , Anjali Pandey
发明人: Yonghong Song , Qing Xu , Shawn M. Bauer , Zhaozhong J. Jia , Mukund Mehrotra , Anjali Pandey
IPC分类号: C07D471/04 , C07D401/04 , A61K31/506 , C07D403/04 , C07D473/16 , A61K31/52 , A61K31/496 , C07D401/14 , A61K31/635 , C07D487/04 , A61K31/5377 , C07D403/14 , A61K31/551 , A61K31/538 , A61K31/541 , A61P43/00 , A61P9/00 , A61P29/00 , A61P37/00 , A61P35/00 , C07D498/04 , A61K31/519
CPC分类号: C07D471/04 , C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D473/16
摘要: The present invention is directed to compounds of formula I-II and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin's Lymphoma.
摘要翻译: 本发明涉及式I-II化合物及其药学上可接受的盐,酯和前体药物,它们是syk和/或JAK激酶的抑制剂。 本发明还涉及用于制备这种化合物的中间体,这种化合物的制备,含有这种化合物的药物组合物,抑制性syk和/或JAK激酶活性的方法,抑制血小板聚集的方法以及预防方法 或治疗至少部分通过syk和/或JAK激酶活性介导的许多病症,例如不期望的血栓形成和非霍奇金淋巴瘤。
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