公开(公告)号：US20090275606A1

公开(公告)日：2009-11-05

申请号：US12427137

申请日：2009-04-21

Applicant: Dinesh Chikkanna ,  Clive McCarthy ,  Henrik Moebitz ,  Chetan Pandit ,  Ramesh Sistla ,  Hosahalli Subramanya

Inventor： Dinesh Chikkanna ,  Clive McCarthy ,  Henrik Moebitz ,  Chetan Pandit ,  Ramesh Sistla ,  Hosahalli Subramanya

IPC: A61K31/437 ,  C07D487/04 ,  C07D455/02 ,  A61K31/4375 ,  A61P35/00

CPC classification number: C07D471/04 ,  C07D471/14 ,  C07D491/14

Abstract: The present invention relates to compounds of formula I and pharmaceutically acceptable salts. These compounds can act as potential MEK inhibitors in the treatment of hyperproliferative diseases, like cancer and inflammation. The present invention also reveals methods of preparation thereof.

Abstract translation: 本发明涉及式I化合物及其药学上可接受的盐。 这些化合物可作为潜在的MEK抑制剂治疗过度增殖性疾病，如癌症和炎症。 本发明还揭示了其制备方法。