公开(公告)号：US06288043B1

公开(公告)日：2001-09-11

申请号：US09336005

申请日：1999-06-18

Applicant: Robert C. Spiro ,  LinShu Liu

Inventor： Robert C. Spiro ,  LinShu Liu

IPC: A61K31715

CPC classification number: A61L27/20 ,  A61K47/61 ,  A61L2400/06 ,  A61L27/54 ,  A61L27/227

Abstract: An injectable composition is provided for promoting bone and/or cartilage growth comprising hyaluronic acid cross-linked to sulfated polysaccharide through linking groups. The linking groups are diamines or amino polyalkylene glycols. The sulfated polysaccharide binds growth factors suitable for promoting tissue growth at the site of application of the composition.

Abstract translation: 提供可注射组合物用于促进骨和/或软骨生长，包括通过连接基团与硫酸化多糖交联的透明质酸。 连接基团是二胺或氨基聚亚烷基二醇。 硫酸化多糖结合适用于在组合物施用部位促进组织生长的生长因子。