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    Compositions containing poly(lactic acid), bacteriocin(s), plasticizers(s), and optionally pore forming agent(s), and methods or making
    3.
    发明授权
    Compositions containing poly(lactic acid), bacteriocin(s), plasticizers(s), and optionally pore forming agent(s), and methods or making 有权
    包含聚（乳酸），细菌素，增塑剂和任选的成孔剂的组合物，以及方法或制备

    公开(公告)号：US08268905B1

    公开(公告)日：2012-09-18

    申请号：US12583110

    申请日：2009-08-14

    Applicant: LinShu Liu ,  David R. Coffin ,  Kevin B. Hicks ,  Zhonglin T. Jin

    Inventor： LinShu Liu ,  David R. Coffin ,  Kevin B. Hicks ,  Zhonglin T. Jin

    IPC: C08J9/00

    CPC classification number: C08L67/04 ,  C08J3/203 ,  C08J9/0023 ,  C08J9/26 ,  C08J2201/0422 ,  C08J2201/0446 ,  C08J2201/0464 ,  C08J2367/04 ,  C08J2489/00 ,  C08K5/0058 ,  C08K5/103 ,  C08L89/00

    Abstract: A composition containing poly(lactic acid), at least one bacteriocin (e.g., nisin, generally in the form of Nisaplin®), and at least one plasticizer (e.g., lactic acid, lactide, triacetin, glycerol triacetate), and optionally at least one pore forming agent. A method of making the composition, involving mixing about 100% of the total of the poly(lactic acid), about 50% to about 90% of the total of the at least one plasticizer, and optionally at least one pore forming agent at a first temperature of about 150° to about 170° C. to form a mixture, cooling the mixture to a second temperature of about 115° to about 125° C., adding at least one bacteriocin and about 10% to about 50% of the total of the at least one plasticizer and the remainder of the total of the poly(lactic acid) to the mixture and mixing to form the composition.

    Abstract translation: 含有聚（乳酸），至少一种细菌素（例如通常为Nisaplin的形式的乳链菌肽）和至少一种增塑剂（例如乳酸，丙交酯，甘油三乙酸酯，甘油三乙酸酯）和任选地至少 一种成孔剂。 一种制备该组合物的方法，包括混合约100％的聚（乳酸），约50％至约90％的至少一种增塑剂和任选的至少一种成孔剂 第一温度为约150℃至约170℃以形成混合物，将混合物冷却至约115℃至约125℃的第二温度，加入至少一种细菌素和约10％至约50％的 将总共​​至少一种增塑剂和剩余的聚（乳酸）的总量混合并混合以形成组合物。

    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
    4.
    发明授权
    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making 失效
    由天然聚合物和合成聚合物制成的多孔聚合物基质和任选的至少一种阳离子和制备方法

    公开(公告)号：US07446131B1

    公开(公告)日：2008-11-04

    申请号：US11058034

    申请日：2005-02-15

    Applicant: LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    Inventor： LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    IPC: C08B37/00

    CPC classification number: C08B37/0045 ,  A61L27/26 ,  A61L27/56 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/05 ,  C08J2367/04 ,  C08J2405/00 ,  C08L5/06 ,  C08L67/04 ,  C08L5/04 ,  C08L2666/18 ,  C08L2666/26

    Abstract: A porous polymeric matrix containing at least one natural polymer and at least one synthetic polymer and optionally at least one cation. Furthermore, a method of making a porous polymeric matrix involving mixing at least one natural polymer and inorganic salts with a solution comprising at least one solvent and at least one synthetic polymer to form a slurry, casting the slurry in a mold and removing the solvent to form solid matrices, immersing the solid matrices in deionized water to allow natural polymer cross-linking and pore creation to occur simultaneously, and drying the matrices to create a porous polymeric matrix; wherein the matrix contains a cation. Also, a method of making a porous polymeric matrix, involving mixing at least one natural polymer in an aqueous solvent and mixing at least one synthetic polymer in an organic solvent, combining the mixtures and casting in a mold, and separately removing said aqueous solvent and said organic solvent to form a porous polymeric matrix; wherein the porous polymeric matrix does not contain a cation.

    Abstract translation: 含有至少一种天然聚合物和至少一种合成聚合物和任选的至少一种阳离子的多孔聚合物基质。 此外，制备多孔聚合物基质的方法包括将至少一种天然聚合物和无机盐与包含至少一种溶剂和至少一种合成聚合物的溶液混合以形成浆料，将浆料浇铸到模具中并除去溶剂 形成固体基质，将固体基质浸入去离子水中以允许天然聚合物交联和孔产生同时发生，并干燥基质以产生多孔聚合物基质; 其中所述基质含有阳离子。 而且，制备多孔聚合物基质的方法，包括在水性溶剂中混合至少一种天然聚合物并在有机溶剂中混合至少一种合成聚合物，将该混合物和铸件混合在模具中，并分别除去所述水性溶剂和 所述有机溶剂形成多孔聚合物基质; 其中所述多孔聚合物基质不含阳离子。

    Cross-linked polysaccharide drug carrier
    5.
    发明授权
    Cross-linked polysaccharide drug carrier 失效
    交联多糖药物载体

    公开(公告)号：US06303585B1

    公开(公告)日：2001-10-16

    申请号：US09110381

    申请日：1998-07-01

    Applicant: Robert C. Spiro ,  Andrea Y. Thompson ,  LinShu Liu

    Inventor： Robert C. Spiro ,  Andrea Y. Thompson ,  LinShu Liu

    IPC: C08B3700

    CPC classification number: A61K9/146 ,  A61K9/0019 ,  A61K47/36 ,  A61K47/61 ,  C08B37/0063

    Abstract: A carrier and a method for preparing it are provided for use in the delivery of therapeutic agents. A polysaccharide is reacted with an oxidizing agent to open sugar rings on the polysaccharide to form aldehyde groups. The aldehyde groups are reacted to form covalent oxime linkages with a second polysaccharide and each of the first and second polysaccharide is selected from the group consisting of hyaluronic acid, dextran, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate, heparan, heparan sulfate and alginate.

    Abstract translation: 提供载体及其制备方法用于递送治疗剂。 多糖与氧化剂反应以在多糖上开放糖环以形成醛基。 醛基反应以与第二多糖形成共价肟键，并且第一和第二多糖中的每一种选自透明质酸，葡聚糖，硫酸葡聚糖，硫酸软骨素，硫酸皮肤素，硫酸角质素，肝素，硫酸乙酰肝素 和藻酸盐。

    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making
    8.
    发明授权
    Porous polymeric matrices made of natural polymers and synthetic polymers and optionally at least one cation and methods of making 有权
    由天然聚合物和合成聚合物制成的多孔聚合物基质和任选的至少一种阳离子和制备方法

    公开(公告)号：US08080590B1

    公开(公告)日：2011-12-20

    申请号：US12157301

    申请日：2008-06-09

    Applicant: LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    Inventor： LinShu Liu ,  Marshall L. Fishman ,  Kevin B. Hicks

    IPC: C08B37/00

    CPC classification number: C08B37/0045 ,  A61L27/26 ,  A61L27/56 ,  C08J9/0061 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/05 ,  C08J2367/04 ,  C08J2405/00 ,  C08L5/06 ,  C08L67/04 ,  C08L5/04 ,  C08L2666/18 ,  C08L2666/26

    Abstract: A porous polymeric matrix containing at least one natural polymer and at least one synthetic polymer and optionally at least one cation. Furthermore, a method of making a porous polymeric matrix involving mixing at least one natural polymer and inorganic salts with a solution comprising at least one solvent and at least one synthetic polymer to form a slurry, casting the slurry in a mold and removing the solvent to form solid matrices, immersing the solid matrices in deionized water to allow natural polymer cross-linking and pore creation to occur simultaneously, and drying the matrices to create a porous polymeric matrix; wherein the matrix contains a cation. Also, a method of making a porous polymeric matrix, involving mixing at least one natural polymer in an aqueous solvent and mixing at least one synthetic polymer in an organic solvent, combining the mixtures and casting in a mold, and separately removing said aqueous solvent and said organic solvent to form a porous polymeric matrix; wherein the porous polymeric matrix does not contain a cation.

    Abstract translation: 含有至少一种天然聚合物和至少一种合成聚合物和任选的至少一种阳离子的多孔聚合物基质。 此外，制备多孔聚合物基质的方法包括将至少一种天然聚合物和无机盐与包含至少一种溶剂和至少一种合成聚合物的溶液混合以形成浆料，将浆料浇铸到模具中并除去溶剂 形成固体基质，将固体基质浸入去离子水中以允许天然聚合物交联和孔产生同时发生，并干燥基质以产生多孔聚合物基质; 其中所述基质含有阳离子。 而且，制备多孔聚合物基质的方法，包括在水性溶剂中混合至少一种天然聚合物并在有机溶剂中混合至少一种合成聚合物，将该混合物和铸件混合在模具中，并分别除去所述水性溶剂和 所述有机溶剂形成多孔聚合物基质; 其中所述多孔聚合物基质不含阳离子。

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