公开(公告)号：US20110144136A1

公开(公告)日：2011-06-16

申请号：US13058465

申请日：2009-08-07

申请人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

发明人： Helene Bazin-Lee ,  Diane Mary Coe ,  Linos Lazarides ,  Charlotte Jane Mitchell ,  Stephen Allan Smith ,  Naimisha Trivedi

IPC分类号： A61K31/522 ,  C07D473/18 ,  C07D473/16 ,  A61P29/00 ,  A61P37/08

CPC分类号： C07D473/16 ,  A61K31/522 ,  C07D473/18

摘要： The present invention relates to compounds of formula (I): wherein R1 is C1-6alkylamino, or C1-6alkoxy; R2 is a group having the structure: n is an integer having a value of 1 to 6; Het is a 6-membered saturated heterocycle containing one nitrogen atom wherein Het is attached to the —(CH2)n— moiety at any carbon atom of the heterocycle; R3 is hydrogen, C1-8alkyl, or C3-7cycloalkylC0-6alkyl; and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

摘要翻译： 本发明涉及式（I）的化合物：其中R 1是C 1-6烷基氨基或C 1-6烷氧基; R2是具有以下结构的基团：n是具有1至6的整数; Het是含有一个氮原子的6元饱和杂环，其中Het与杂环的任何碳原子连接至 - （CH 2）n - 部分; R3是氢，C1-8烷基或C3-7环烷基C0-6烷基; 其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。