中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

61 records (took 0.014 seconds)

    Crystal structure of human Pim-1 kinase protein complexes and binding pockets thereof, and uses thereof in drug design
    18.
    发明授权
    Crystal structure of human Pim-1 kinase protein complexes and binding pockets thereof, and uses thereof in drug design 失效
    人类Pim-1激酶蛋白复合物及其结合口袋的晶体结构及其在药物设计中的应用

    公开(公告)号：US07666646B2

    公开(公告)日：2010-02-23

    申请号：US11242666

    申请日：2005-10-04

    Applicant: Marc Jacobs ,  Brian Hare ,  Lovorka Swenson

    Inventor： Marc Jacobs ,  Brian Hare ,  Lovorka Swenson

    IPC: C12N9/12

    CPC classification number: G01N33/5748 ,  C07K2299/00 ,  C12N9/1205 ,  G01N33/573 ,  G01N33/6803 ,  G01N33/6842 ,  G01N2333/91205 ,  G01N2333/9121

    Abstract: The present invention relates to the X-ray analysis of crystalline molecules or molecular complexes of human Pim-1. The present invention also relates to Pim-1-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. In addition, this invention relates to methods of using the structure coordinates to screen for and design compounds, including inhibitory compounds, that bind to Pim-1 protein, Pim-1 protein complexes, or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising Pim-1 protein, Pim-1 protein complexes with adenosine, staurosporine or 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one and methods to produce these crystals.

    Abstract translation: 本发明涉及人Pim-1的结晶分子或分子复合物的X射线分析。 本发明还涉及Pim-1样结合口袋。 本发明提供了一种计算机，其包括用这种结合口袋的结构坐标编码的数据存储介质。 本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。 此外，本发明涉及使用结构坐标筛选和设计结合Pim-1蛋白，Pim-1蛋白复合物或其同系物的化合物（包括抑制性化合物）的方法。 本发明还涉及包含Pim-1蛋白，Pim-1蛋白复合物与腺苷，星形孢菌素或2-（4-吗啉基）-8-苯基-4H-1-苯并吡喃-4-酮的可结晶组合物和晶体以及产生 这些晶体。

    Handbag
    19.
    外观设计
    Handbag 失效

    公开(公告)号：USD453070S1

    公开(公告)日：2002-01-29

    申请号：US29139943

    申请日：2001-04-10

    Applicant: Marc Jacobs

    Designer： Marc Jacobs

    Pair of sandals
    20.
    外观设计
    Pair of sandals 失效
    一双凉鞋

    公开(公告)号：USD448145S1

    公开(公告)日：2001-09-25

    申请号：US29134850

    申请日：2001-01-03

    Applicant: Marc Jacobs

    Designer： Marc Jacobs

Patent Agency Ranking