公开(公告)号：US5723500A

公开(公告)日：1998-03-03

申请号：US649389

申请日：1996-05-17

Applicant: Orum D. Stringer ,  John C. Brahms ,  Malathy Subramanian ,  Ernest E. Kelly

Inventor： Orum D. Stringer ,  John C. Brahms ,  Malathy Subramanian ,  Ernest E. Kelly

IPC: A61K8/00 ,  A01N31/08 ,  A61K8/24 ,  A61K8/25 ,  A61K8/30 ,  A61K8/33 ,  A61K8/34 ,  A61K31/05 ,  A61Q11/00 ,  C07C39/06 ,  C07C39/14 ,  C07C39/15 ,  C07C39/17

CPC classification number: A61Q11/00 ,  A61K31/05 ,  A61K8/347 ,  C07C39/14 ,  C07C39/15 ,  C07C39/17 ,  C07C2103/26

Abstract: An oral antiplaque composition and treatment of teeth therewith wherein the essential antiplaque agent is a substantially water insoluble noncationic antibacterial phenol containing, relative to the hydroxyl group, an alkyl or cycloalkyl group, preferably tert.-butyl (t-butyl), in 2-position, and substituents in one or both of the 4- and 5-positions, one of which may be phenyl or 2', 3' and/or 4' substituted alkyl or cycloalkyl phenyl, preferably 4'-t-butyl phenyl or a phenanthrene containing a hydroxyl substituent in the 2- or 3-position and alkyl or cycloalkyl, preferably t-butyl, substituents in the other of the 2- and 3-positions and in at least one of the other rings. Novel antibacterial alkylated phenols are also described.

Abstract translation: 口腔防斑组合物和治疗牙齿，其中必需抗牙斑剂是基本上不溶于水的非阳离子抗菌酚，相对于羟基，烷基或环烷基，优选叔丁基（叔丁基），2- 位置和取代基中的一个或两个，其中一个可以是苯基或2'，3'和/或4'取代的烷基或环烷基苯基，优选4'-叔丁基苯基或 在2-位或3-位的另一个位置和至少一个其它环中含有2-或3-位的羟基取代基和烷基或环烷基，优选叔丁基取代基的菲。 还描述了新的抗菌烷基化酚。

公开(公告)号：US4593106A

公开(公告)日：1986-06-03

申请号：US616635

申请日：1984-06-04

Applicant: Orum D. Stringer ,  Joseph Weinstock ,  James W. Wilson

Inventor： Orum D. Stringer ,  Joseph Weinstock ,  James W. Wilson

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P9/12 ,  A61P43/00 ,  C07D209/38

CPC classification number: C07D209/38 ,  Y02P20/55

Abstract: 4-[2-(Dialkylamino)ethyl]-7-hydroxyisatins are prepared by internal condensation of an oxime followed by removal of protecting groups. The compounds are D.sub.2 -agonists and, thereby, have anti-hypertensive activity. A species of the group is 4-[2-(di-n-propylamino)ethyl]-4-hydroxyisatin.

Abstract translation: 通过肟的内部缩合，然后除去保护基来制备4- [2-（二烷基氨基）乙基] -7-羟基西汀。 化合物是D2-激动剂，因此具有抗高血压活性。 该物种是4- [2-（二正丙基氨基）乙基] -4-羟基靛红。