公开(公告)号：US20220162194A1

公开(公告)日：2022-05-26

申请号：US17665204

申请日：2022-02-04

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D207/26 ,  C07D401/12 ,  C07D471/04 ,  C07D403/14 ,  C07D417/14 ,  C07D401/14

摘要： The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US11312704B2

公开(公告)日：2022-04-26

申请号：US17384369

申请日：2021-07-23

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D207/26 ,  C07D401/12 ,  C07D471/04 ,  C07D417/14 ,  C07D401/14

摘要： The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US11524940B1

公开(公告)日：2022-12-13

申请号：US17525514

申请日：2021-11-12

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D207/00 ,  A61K31/40 ,  A61P31/14 ,  C07D213/90 ,  A61K45/06

摘要： The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US11472793B2

公开(公告)日：2022-10-18

申请号：US17665204

申请日：2022-02-04

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D207/26 ,  C07D401/12 ,  C07D471/04 ,  C07D403/14 ,  C07D417/14 ,  C07D401/14

摘要： The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US20210355111A1

公开(公告)日：2021-11-18

申请号：US17384369

申请日：2021-07-23

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D403/14 ,  C07D417/14 ,  C07D401/14 ,  C07D207/26 ,  C07D401/12 ,  C07D471/04

摘要： The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US11174231B1

公开(公告)日：2021-11-16

申请号：US17322221

申请日：2021-05-17

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D207/00 ,  A61K31/40 ,  A61P31/14 ,  C07D213/90 ,  A61K45/06

摘要： The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.