公开(公告)号：US20220380347A1

公开(公告)日：2022-12-01

申请号：US17247000

申请日：2021-05-03

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Uri Lopatin ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K45/06

摘要： The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US20240270721A1

公开(公告)日：2024-08-15

申请号：US18461179

申请日：2023-09-05

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D207/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

CPC分类号： C07D403/12 ,  C07D207/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04

摘要： The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US11124497B1

公开(公告)日：2021-09-21

申请号：US17230727

申请日：2021-04-14

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D207/26 ,  C07D471/04 ,  C07D417/14

摘要： The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Exemplary compounds provided include Formula II-I, where R3, RB are provided herein:

公开(公告)号：US20240277795A1

公开(公告)日：2024-08-22

申请号：US18444009

申请日：2024-02-16

申请人： Pardes Biosciences, Inc.

发明人： Daniel J. Buzard ,  Walter Keung ,  Dange Vijay Kumar ,  Erik Verner ,  Lee D. Arnold

IPC分类号： A61K38/05 ,  A61K45/06 ,  A61P31/14 ,  C07K1/107

CPC分类号： A61K38/05 ,  A61K45/06 ,  A61P31/14 ,  C07K1/1077

摘要： The disclosure provides compounds with nitrile warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with nitrile warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US20240208933A1

公开(公告)日：2024-06-27

申请号：US18589700

申请日：2024-02-28

申请人： Pardes Biosciences, Inc.

发明人： Ruiping Wang ,  Meiting Shi ,  Arnold D. Lee ,  David J. Turnquist

IPC分类号： C07D401/12 ,  A61K31/454 ,  A61K45/06

CPC分类号： C07D401/12 ,  A61K31/454 ,  A61K45/06

摘要： The disclosure is in part directed to crystalline forms of 7-chloro-N—((S)-1-(((S)-1-cyano-2-((S)-2-oxopiperidin-3-yl)ethyl)amino)-3-cyclopropyl-1-oxopropan-2-yl)-1H-indole-2-carboxamide and pharmaceutical compositions thereof.

公开(公告)号：US20230192663A1

公开(公告)日：2023-06-22

申请号：US18168803

申请日：2023-02-14

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D207/26 ,  C07D417/14 ,  C07D403/14 ,  C07D471/04 ,  C07D401/14

CPC分类号： C07D403/12 ,  C07D401/12 ,  C07D207/26 ,  C07D417/14 ,  C07D403/14 ,  C07D471/04 ,  C07D401/14

摘要： The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US20240270693A1

公开(公告)日：2024-08-15

申请号：US17828881

申请日：2022-05-31

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D213/90 ,  A61K45/06

CPC分类号： C07D213/90 ,  A61K45/06

摘要： The disclosure provides compounds with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US20230212152A1

公开(公告)日：2023-07-06

申请号：US18008914

申请日：2021-06-09

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D207/267 ,  C07D417/14 ,  C07D209/42 ,  C07D471/04 ,  C07D405/14 ,  C07D403/14 ,  C07D401/14 ,  C07D471/10 ,  C07D401/12 ,  C07D417/12 ,  C07D487/10 ,  C07D209/52 ,  C07D209/44 ,  C07D209/56 ,  C07D413/14 ,  C07D491/107 ,  C07D513/04 ,  C07D491/18 ,  C07F7/08 ,  C07D207/34 ,  C07D221/20 ,  C07D209/54 ,  A61P31/14 ,  A61K47/64 ,  A61K45/06 ,  C12N9/50

CPC分类号： C07D403/12 ,  C07D207/267 ,  C07D417/14 ,  C07D209/42 ,  C07D471/04 ,  C07D405/14 ,  C07D403/14 ,  C07D401/14 ,  C07D471/10 ,  C07D401/12 ,  C07D417/12 ,  C07D487/10 ,  C07D209/52 ,  C07D209/44 ,  C07D209/56 ,  C07D413/14 ,  C07D491/107 ,  C07D513/04 ,  C07D491/18 ,  C07F7/0812 ,  C07F7/0816 ,  C07D207/34 ,  C07D221/20 ,  C07D209/54 ,  A61P31/14 ,  A61K47/64 ,  A61K45/06 ,  C12N9/506 ,  C12Y304/22066

摘要： The disclosure provides compounds of formula II with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US20220402896A1

公开(公告)日：2022-12-22

申请号：US17859827

申请日：2022-07-07

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D207/26 ,  C07D471/04 ,  C07D401/12 ,  C07D403/14 ,  C07D401/14 ,  C07D417/14

摘要： The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.

公开(公告)号：US20220324844A1

公开(公告)日：2022-10-13

申请号：US17841172

申请日：2022-06-15

申请人： Pardes Biosciences, Inc.

发明人： Lee D. Arnold ,  Andy Jennings ,  Walter Keung

IPC分类号： C07D403/12 ,  C07D207/26 ,  C07D471/04 ,  C07D401/12 ,  C07D403/14 ,  C07D401/14 ,  C07D417/14

摘要： The disclosure provides compounds, such as compounds of Formula II, with warheads and their use in treating medical diseases or disorders, such as viral infections. Pharmaceutical compositions and methods of making various compounds with warheads are provided. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease.