公开(公告)号：US20080233655A1

公开(公告)日：2008-09-25

申请号：US10594699

申请日：2005-03-31

Applicant: Peter Meikle ,  John Hopwood ,  Maria Fuller ,  Phillip Whitfield ,  Peter Sharp

Inventor： Peter Meikle ,  John Hopwood ,  Maria Fuller ,  Phillip Whitfield ,  Peter Sharp

IPC: G01N33/00

CPC classification number: G01N33/92

Abstract: A method of ascertaining the LSD (Lysosomal storage disorder) status of an individual comprising taking a tissue or body fluid sample from the individual and estimating a level in the sample of each of three or more compound indicators. The indicators reflect the level of respectively each of three or more lipid containing storage associated compounds. The levels are used to calculate an LSD index number which is then compared with a standard to provide an assessment of the LSD status of the individual. The indicator compounds are conveniently phospholipids, glycolipids or lipopolysaccharide species measured by mass spectrometry. The method may be used to ascertain the nature of the disorder from which the individual stuffers, and its severity. It may also be used to monitor the progress of treatment and to ascertain the prospects of an individual contracting an LSD by providing a subclinical indicators for the condition.

Abstract translation: 确定个体的LSD（溶酶体储存障碍）状态的方法，包括从个体取组织或体液样品并估计三个或更多个化合物指示剂中每一个的样品中的水平。 这些指标反映了三种或更多种与脂质相关的化合物中各自的水平。 水平用于计算LSD指数，然后将其与标准进行比较，以提供个体的LSD状态的评估。 指示剂化合物方便地通过质谱法测量磷脂，糖脂或脂多糖物质。 该方法可以用于确定个体填充物的病症的性质及其严重性。 它还可用于监测治疗进展情况，并通过为病情提供亚临床指标来确定个体承包LSD的前景。