公开(公告)号：US07405327B2

公开(公告)日：2008-07-29

申请号：US11596292

申请日：2005-05-04

申请人： Frank Haese ,  Arnd Bottcher ,  Bernd Stein ,  Wolfgang Reif ,  Johann-Peter Melder ,  Karl-Heinz Roβ ,  Heinz Rutter ,  Shelue Liang ,  Stefan Rittinger

发明人： Frank Haese ,  Arnd Bottcher ,  Bernd Stein ,  Wolfgang Reif ,  Johann-Peter Melder ,  Karl-Heinz Roβ ,  Heinz Rutter ,  Shelue Liang ,  Stefan Rittinger

IPC分类号： C07C209/26

CPC分类号： C07C209/26 ,  C07C209/16 ,  C07C213/02 ,  C07D295/027 ,  C07D295/03 ,  C07D295/088 ,  C08G59/50 ,  Y02P20/582 ,  C07C211/06 ,  C07C211/08 ,  C07C211/35 ,  C07C217/08

摘要： Process for the continuous preparation of an amine by reaction of a primary or secondary alcohol, aldehyde and/or ketone with hydrogen and a nitrogen compound selected from the group consisting of ammonia, primary and secondary amines at a temperature in the range from 60 to 300° C. in the presence of a copper-containing catalyst, wherein the catalytically active composition of the catalyst prior to reduction with hydrogen comprises from 20 to 85% by weight of aluminum oxide (Al2O3), zirconium dioxide (ZrO2), titanium dioxide (TiO2) and/or silicon dioxide (SiO2), from 1 to 70% by weight of oxygen-containing compounds of copper, calculated as CuO, from 0 to 50% by weight of oxygen-containing compounds of magnesium, calculated as MgO, oxygen-containing compounds of chromium, calculated as Cr2O3, oxygen-containing compounds of zinc, calculated as ZnO, oxygen-containing compounds of barium, calculated as BaO, and/or oxygen-containing compounds of calcium, calculated as CaO, and less than 30% by weight of oxygen-containing compounds of nickel, calculated as NiO, based on the oxygen-containing compounds of copper, calculated as CuO, and the reaction is carried out isothermally in the gas phase in a tube reactor.

摘要翻译： 通过伯醇或仲醇，醛和/或酮与氢和选自氨，伯胺和仲胺的氮化合物在60至300℃的温度下反应来连续制备胺的方法 在含铜催化剂存在下，其中催化剂在用氢还原之前的催化活性组合物包含20至85重量％的氧化铝（Al 2 O 3 > 3），二氧化锆（ZrO 2），二氧化钛（TiO 2）和/或二氧化硅（SiO 2） ），1至70重量％的以CuO计的铜的含氧化合物，0至50重量％的以MgO计的含氧化合物的镁，含氧化合物的铬，其计算为Cr 以ZnO计算的含氧化合物锌，以BaO表示的含氧化合物的钡，以BaO计算， /或以CaO计的钙的含氧化合物，以NiO计，以CuO计的含铜化合物计，小于30重量％的含氧化合物的镍，反应为 在管式反应器中在气相中等温进行。

公开(公告)号：US06689914B2

公开(公告)日：2004-02-10

申请号：US10234170

申请日：2002-09-05

申请人： Martin Schäfer ,  Arnd Böttcher ,  Andreas Kramer ,  Arthur Höhn ,  Shelue Liang ,  Frank Funke

发明人： Martin Schäfer ,  Arnd Böttcher ,  Andreas Kramer ,  Arthur Höhn ,  Shelue Liang ,  Frank Funke

IPC分类号： C07C2926

CPC分类号： C07C209/26

摘要： The preparation of amines of the formula (I): R1R2CH—N R3R4  (I) in which R1, R2, R3 and R4, independently of one another, are hydrogen, straight-chain or branched C1-C12-alkyl, C3-C12-cycloalkyl, C6-C10-aryl or C7-C11-aralkyl, takes place by catalytic, reductive amination of mixtures comprising carbonyl compounds of the formula (II) and/or alcohols of the formula (III) R1—C(═O)—R2  (II) R1—CH(OH)—R2  (III) which also comprise at least 50 ppm, based on the mixtures, of halogen, with nitrogen compounds of the formula (IV): H N R3 R4  (IV) with the abovementioned meanings for R1 to R4, in the presence of Co- and/or Ni-containing catalysts, which comprises carrying out the reductive amination additionally in the presence of solid acidic cocatalysts.

摘要翻译： 式（I）的胺的制备：其中R 1，R 2，R 3和R 4彼此独立地是氢，直链或支链的C 1 -C 12 - 烷基，C 3 -C 12 - 环烷基，C 6 -C 10 - 芳基或C 7 -C 11 - 芳烷基，其通过催化还原胺化包括式（II）的羰基化合物和/或式（III）的醇， 包含基于混合物的卤素至少50ppm与式（IV）的氮化合物：在上述对R 1至R 4的含义中，在Co-和/或Ni- 其包括另外在固体酸性助催化剂存在下进行还原胺化。

公开(公告)号：US06462236B2

公开(公告)日：2002-10-08

申请号：US09983307

申请日：2001-10-24

申请人： Shelue Liang ,  Frank Funke ,  Arthur Höhn

发明人： Shelue Liang ,  Frank Funke ,  Arthur Höhn

IPC分类号： C07C20926

CPC分类号： C07C209/26 ,  C07C211/29

摘要： Amines of the formula (I) R1R2CH—NR3R4  (I) where R1, R2, R3 and R4 are each, independently of one another, hydrogen, straight-chain or branched C1-C12-alkyl, C3-C12-cycloalkyl, C6-C10-aryl or C7-C11-aralkyl, where at least one of the radicals R1 and R2 is aryl or aralkyl whose aromatic unit is substituted by at least one halogen, are prepared by catalytic, hydrogenative amination of carbonyl compounds of the formula (II) or alcohols of the formula (III) R1—C(═O)—R2  (II) R1—CH(OH)—R2  (III) by means of nitrogen compounds of the formula (IV) HNR3R4  (IV) where R1 to R4 are as defined above, in the presence of Co- and/or Ni-containing catalysts, in the additional presence of solid acid cocatalysts and in the absence of organic sulfur compounds.

摘要翻译： 式（I）的胺其中R 1，R 2，R 3和R 4各自独立地为氢，直链或支链C 1 -C 12 - 烷基，C 3 -C 12 - 环烷基，C 6 -C 10 - 芳基或C 7 -C 12 - C 11 - 芳烷基，其中基团R 1和R 2中的至少一个是其芳族单元被至少一个卤素取代的芳基或芳烷基，其通过式（II）的羰基化合物的催化，氢化胺化或式 （III）通过其中R 1至R 4如上所定义的式（Ⅳ）的氮化合物在存在Co和/或Ni的催化剂的情况下，在固体酸助催化剂的另外存在下，在不存在 有机硫化合物。

公开(公告)号：US06429339B1

公开(公告)日：2002-08-06

申请号：US09700365

申请日：2000-11-15

申请人： Shelue Liang ,  Rolf Fischer ,  Frank Stein ,  Joachim Wulff-Döring

发明人： Shelue Liang ,  Rolf Fischer ,  Frank Stein ,  Joachim Wulff-Döring

IPC分类号： C07C4500

CPC分类号： B01J23/10 ,  C07C45/48 ,  C07C49/395

摘要： A process for preparing cyclopentanone by reacting adipic esters of the formula R1OOC—(CH2)4—COOR2  I where R1 and R2 are each alkyl having from 1 to 12 carbon atoms, cycloalkyl having 5 or 6 carbon atoms, aralkyl or aryl and R2 may additionally be hydrogen, in the presence of oxidic catalysts comprises reacting adipic esters of the formula I having less than 5% by weight of by-products other than adipic esters in the gas phase in the presence of water, a carrier gas and a) from 0.01 to 10% by weight of at least one metal oxide selected from the first or second main group of the periodic table or from the group of the rare earth metals on titanium dioxide or zirconium dioxide as catalyst support, or b) from 0.01 to 50% by weight of at least one metal oxide selected from the second main group of the periodic table on zink oxide as catalyst support.

摘要翻译： 通过使式R 1和R 2的己二酸酯反应制备环戊酮的方法各自是在氧化催化剂存在的情况下，可以另外为氢，其中R 1和R 2各自为具有1至12个碳原子的烷基，具有5或6个碳原子的环烷基或芳基， 包括使式I的己二酸酯在水，载气的存在下，在气相中具有小于5重量％的除己二酸酯之外的副产物，和（ii）0.01至10重量％的至少一种金属 氧化物，其选自周期表的第一或第二主族，或者来自稀土金属的二氧化钛或二氧化锆的组，作为催化剂载体，orb）为0.01至50重量％的至少一种选自 氧化锌作为催化剂载体的周期表第二主要组。

公开(公告)号：US06407294B1

公开(公告)日：2002-06-18

申请号：US09529789

申请日：2000-04-20

申请人： Boris Breitscheidel ,  Rolf Pinkos ,  Frank Stein ,  Shelue Liang ,  Rolf Hartmuth Fischer

发明人： Boris Breitscheidel ,  Rolf Pinkos ,  Frank Stein ,  Shelue Liang ,  Rolf Hartmuth Fischer

IPC分类号： C07C2700

CPC分类号： C07C29/149 ,  C07C2601/08 ,  C07C35/06 ,  C07C31/135 ,  C07C31/20

摘要： A process for producing 1,6-hexanediol by hydrogenation of adipic esters and/or 6-hydroxycaproic esters in the gas phase at elevated temperature and elevated pressure in the presence of chromium-free catalysts comprises hydrogenating a) over a catalyst comprising copper, manganese and aluminum as essential constituents or over Raney copper, b) at a temperature of from 150 to 230° C. and a pressure of from 10 to 70 bar, c) at a molar ratio of hydrogen to ester to be hydrogenated within the range from 150:1 to 300:1, and d) at a catalyst space velocity of from 0.01 to 0.3 kg of C6 ester per liter of catalyst per hour.

摘要翻译： 在无铬催化剂存在下，在升高的温度和升高的压力下，气相中己二酸酯和/或6-羟基己酸酯的氢化制备1,6-己二醇的方法包括在包含铜，锰和 铝作为必需组分或在阮内铜上，b）在150-230℃的温度和10至70巴的压力下，c）以氢化至酯的摩尔比在150℃的范围内 ：1至300:1，和d），催化剂空速为每升催化剂每小时0.01至0.3kg的C6酯。