公开(公告)号：US12157759B2

公开(公告)日：2024-12-03

申请号：US16552836

申请日：2019-08-27

Applicant: HudsonAlpha Institute for Biotechnology ,  The UAB Research Foundation

Inventor： Katherine E Varley ,  Richard M Myers ,  Brian S Roberts ,  Jason Gertz ,  Donald J Buchsbaum ,  Andres Forero-Torres ,  Albert F LoBuglio

IPC: C07K14/47 ,  G01N33/574

Abstract: The present disclosure provides for and relates to novel fusion proteins and polypeptides expressed by breast cancer and other cancer cells, and to compositions, materials and methods for detecting, characterizing and treating said breast and other cancers. In one embodiment, the fusion polypeptides are read-through fusion transcripts.

公开(公告)号：US20240384250A1

公开(公告)日：2024-11-21

申请号：US18688840

申请日：2022-09-06

Applicant: THE UAB RESEARCH FOUNDATION

Inventor： Christian FAUL ,  Christopher YANUCIL

IPC: C12N9/24 ,  A61K38/00

Abstract: Uses of soluble α-klotho (sKL) to reduce the activity of FGF23 are described. Because FGF23 is implicated in numerous pathologies of humans and other animals, sKL can be used to treat and prevent such pathologies. Other applications of sKL in pharmaceuticals, modulating FGF23 activity, and modulating hypertrophy in cardiac myocytes are described. The disclosure also describes nucleic acids encoding sKL, their complements, vectors for such nucleic acids, and genetically modified organisms containing such nucleic acids.

公开(公告)号：US20240257947A1

公开(公告)日：2024-08-01

申请号：US18424459

申请日：2024-01-26

Applicant: Body Check, LLC ,  The UAB Research Foundation

Inventor： Andrew Dennis Smith ,  Steven Adam Rothenberg ,  Yujan Shrestha

IPC: G16H30/40 ,  G06T7/00 ,  G06T7/11 ,  G16H15/00 ,  G16H30/20

CPC classification number: G16H30/40 ,  G06T7/0012 ,  G06T7/11 ,  G16H15/00 ,  G06T2207/30004 ,  G16H30/20

Abstract: A system can be configured to: (i) obtain a set of input images depicting one or more bodily structures of a patient; (ii) determine whether one or more key structures are represented within the set of input images by utilizing a key structure detection module; (iii) determine one or more key images of the one or more images of the set of input images by utilizing a key image localization module; (iv) determine key structure segmentation by utilizing a key structure segmentation module; (v) determine one or more patient condition metrics using the key structure segmentation; and (vi) generate a report associated with the patient based upon the one or more patient condition metrics, or generate an entry at one or more practitioner worklists based upon the one or more patient condition metrics.

公开(公告)号：US20240218017A1

公开(公告)日：2024-07-04

申请号：US18482745

申请日：2023-10-06

Applicant: UAB RESEARCH FOUNDATION ,  Endomimetics LLC

Inventor： HO-WOOK JUN ,  BRIGITTA BROTT ,  XIXI ZHANG ,  JUN CHEN ,  BENJAMIN K. ESTEP ,  JENNIFER SHERWOOD ,  PATRICK HWANG

IPC: C07K7/06 ,  A61K38/00

CPC classification number: C07K7/06 ,  A61K38/00

Abstract: Disclosed are peptide amphiphiles comprising a hydrophilic peptide sequence and a hydrophobic tail, wherein the hydrophobic tail comprises a moiety having a substituted C16 alkyl chain, wherein the hydrophilic peptide sequence comprises a degrading sequence (DS), wherein the degrading sequence (DS) comprises the amino acid sequence GTAGLIGQ (SEQ ID NO:1) wherein the DS comprises one or more amino acid substitutions. Also disclosed are compositions, liposomes, gels, and medical devices comprising the peptide amphiphiles and methods of use thereof.

公开(公告)号：US20240131036A1

公开(公告)日：2024-04-25

申请号：US18004069

申请日：2021-07-01

Applicant: THE UAB RESEARCH FOUNDATION ,  United States Government as Represented by the Department of Veterans Affairs

Inventor： Andrzej T. SLOMINSKI ,  Chander RAMAN ,  Shariq QUAYYUM

IPC: A61K31/575 ,  A61K31/57 ,  A61K31/593 ,  A61P31/14

CPC classification number: A61K31/575 ,  A61K31/57 ,  A61K31/593 ,  A61P31/14

Abstract: The present disclosure provides for pharmaceutical composition and methods of treating a condition using the pharmaceutical composition. The condition to be treated in a subject in need of treatment can include an infection or non-viral hyper-inflammation/immune hyperactivation condition. The infection can be a coronavirus infection, HIV infection, influenza infection, or the like, where a direct or indirect result of the infection can be respiratory distress, oxidative stress, and the like that can lead to acute respiratory distress syndrome (ARDS) and/or organ dysfunction or failure.

公开(公告)号：US20240079105A1

公开(公告)日：2024-03-07

申请号：US18460320

申请日：2023-09-01

Applicant: The UAB Research Foundation

Inventor： Andrew Dennis Smith

IPC: G16H10/60 ,  G16H50/20

CPC classification number: G16H10/60 ,  G16H50/20

Abstract: A method for generating a medical record note comprises (i) accessing a corpus of medical documentation for a particular patient; (ii) receiving, at a user interface, chief complaint input indicating a chief complaint associated with the particular patient; (iii) utilizing (a) the chief complaint and (b) at least a portion of the corpus of medical documentation for the particular patient as input to a set of artificial intelligence (AI) modules, the set of AI modules being trained to generate medical record note output in response to medical documentation input; and (iv) generate a medical record note for the particular patient based on output of the set of AI modules.

公开(公告)号：US20240008819A1

公开(公告)日：2024-01-11

申请号：US18345347

申请日：2023-06-30

Applicant: CAMERAD TECHNOLOGIES ,  THE UAB RESEARCH FOUNDATION

Inventor： Carson Arthur Wick ,  Srini Tridandapani ,  Pamela T. Bhatti

IPC: A61B5/00 ,  G06T7/70 ,  G06V10/74 ,  G16H30/20 ,  G16H30/40

CPC classification number: A61B5/70 ,  G06T7/70 ,  G06V10/761 ,  G16H30/20 ,  G16H30/40

Abstract: A system for determining subject orientation includes a medical imaging sensor configured to capture medical imagery of an imaging subject. The system also includes one or more interoceptive sensors, which are configured to obtain interoceptive sensor data indicative of an orientation associated with the system.

公开(公告)号：US20230364267A1

公开(公告)日：2023-11-16

申请号：US18315677

申请日：2023-05-11

Applicant: THE UAB RESEARCH FOUNDATION

Inventor： Jianyi Zhang ,  Yang Zhou ,  Jiacheng Sun ,  Lu WANG

IPC: A61K48/00 ,  A61P9/10

CPC classification number: A61K48/0066 ,  A61K48/0075 ,  A61P9/10

Abstract: In one aspect, the disclosure relates to a synthetic modified mRNA (modRNA) and a novel gene therapy approach using the same that offers efficient, transient, safe, nonimmunogenic, and controlled mRNA delivery to the heart tissue without any risk of genomic integration. In a further aspect, the disclosure relates to methods of using the modRNA to achieve transient and exclusive overexpression of CCND2 only in cardiomyocytes, increasing cell cycle markers, enhancing cardiac function, and promoting myocardial repair. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

公开(公告)号：US11793203B2

公开(公告)日：2023-10-24

申请号：US16070856

申请日：2017-01-20

Applicant: THE UAB RESEARCH FOUNDATION

Inventor： Stephen A. Watts ,  Andrei V. Stanishevsky ,  Mickie L. Powell ,  Robert Novak

IPC: A01N63/22 ,  A01N63/23 ,  A01N25/08 ,  A01N25/10 ,  A01N25/26

CPC classification number: A01N63/22 ,  A01N25/08 ,  A01N25/10 ,  A01N25/26 ,  A01N63/23 ,  A01N63/22 ,  A01N63/23 ,  A01N25/08 ,  A01N25/10 ,  A01N25/22 ,  A01N63/22 ,  A01N63/22 ,  A01N63/22 ,  A01N25/08 ,  A01N25/10 ,  A01N25/22 ,  A01N63/23 ,  A01N25/08 ,  A01N25/10 ,  A01N25/22

Abstract: Compositions and methods of use thereof for delivering an insecticide to water-borne insect larvae are provided. Whereas individual cells of the insecticidal bacteria such as Bacillus thuringiensis israelensis (Bti), are effective in killing insect larvae when ingested by same, their use in aqueous environments is restricted by the time that the bacterial cells remain suspended in water and hence available for ingestion by the larvae. To increase the time that the insecticidal bacteria remain in suspension, it has now been found advantageous to mix bacterial suspensions with nanoparticles comprising carbon that attach to the external surface of the cells.

公开(公告)号：US20230263426A1

公开(公告)日：2023-08-24

申请号：US18041229

申请日：2021-08-13

Applicant: THE UAB RESEARCH FOUNDATION

Inventor： Surya P. Bhatt ,  Arie Nakhmani ,  Sandeep Bodduluri

IPC: A61B5/087 ,  A61B5/091 ,  G16H50/20 ,  G16H20/00

CPC classification number: A61B5/087 ,  A61B5/091 ,  G16H50/20 ,  G16H20/00

Abstract: The present disclosure relates to a method of detecting airflow obstruction using one or more novel metrics associated with a spirometry reading for a subject. The method includes obtaining spirometry data from a subject, generating a first measurement curve and a second measurement curve based on the obtained data for the subject, performing at least a first curve-fitting on the first measurement curve using a Least Absolute Residuals algorithm to estimate a function which closely approximates the spirometry data for the subject by minimizing a sum of absolute deviation, determining a first metric that describes a rate of volume increase based on the estimated function, comparing the first metric to one or more threshold values, and determining a presence or absence of airflow obstruction for the subject based on the comparison of the first metric to the one or more threshold values.