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11.发明申请ANTI-MIGRATION AND ANTI-INVASION THIAZOLE ANALOGS FOR TREATMENT OF CELLULAR PROLIFERATIVE DISEASE 有权用于治疗细胞增殖性疾病的抗移植和抗入侵噻唑类似物公开(公告)号：US20150274714A1
公开(公告)日：2015-10-01
申请号：US14431789
申请日：2013-09-27
发明人： Guangdi Wang , Quan Jiang , Qiu Zhong , Qiang Zhang , Shilong Zheng
IPC分类号： C07D417/12 , C07D277/40 , C07D277/52 , A61K31/427 , C07D277/46 , A61K31/4439 , A61K45/06 , A61K31/426
CPC分类号： C07D417/12 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K45/06 , C07D277/40 , C07D277/44 , C07D277/46 , C07D277/52 , A61K2300/00
摘要： Thiazole analog compounds and their pharmaceutically acceptable salts are disclosed, including pharmaceutical compositions comprising the thiazole analog compounds, either alone or in combination with at least one additional therapeutic agent, and/or with a pharmaceutically acceptable carrier. Methods of using the thiazole analog compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative diseases, such as cancer, are also disclosed.
摘要翻译： 公开了噻唑类似物及其药学上可接受的盐，包括单独或与至少一种另外的治疗剂组合的包含噻唑类似物化合物的药物组合物和/或药学上可接受的载体。 还公开了单独或与至少一种另外的治疗剂组合使用噻唑类似物化合物在预防或治疗细胞增殖性疾病如癌症中的方法。
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公开(公告)号：US20150148409A1
公开(公告)日：2015-05-28
申请号：US14597252
申请日：2015-01-15
申请人： THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND , UNITED STATES DEPARTMENT OF AGRICULTURE , XAVIER UNIVERSITY OF LOUISIANA
发明人： Guangdi WANG , Matthew E. BUROW , Stephen M. BOUE , Thomas E. WIESE , Quan JIANG
IPC分类号： A61K31/353
CPC分类号： A61K31/353 , A61K31/352 , C07D311/38 , C07D493/04
摘要： Provided are compositions for treatment of cancers, including breast cancer, comprising at least one novel daidzein analog, as well as methods of using the same for preventing or treating cancer or tumor growth.
摘要翻译： 提供了用于治疗包括至少一种新的黄豆苷原类似物的癌症（包括乳腺癌）的组合物，以及用于预防或治疗癌症或肿瘤生长的方法。
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公开(公告)号：US20150045296A1
公开(公告)日：2015-02-12
申请号：US14388412
申请日：2013-03-15
CPC分类号： A61K9/0048 , A61K38/1709
摘要： Compositions useful for treatment of retinal pathologies, including diabetic retinopathy, and methods of making and using said compositions, are provided.
摘要翻译： 提供了可用于治疗视网膜病变（包括糖尿病性视网膜病变）的组合物，以及制备和使用所述组合物的方法。
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公开(公告)号：US11046715B2
公开(公告)日：2021-06-29
申请号：US16463622
申请日：2017-11-27
发明人： Guangdi Wang , Shilong Zheng , Jiawang Liu , Qiu Zhong , Shanchun Guo
摘要： The present disclosure relates to boronic derivatives of hydroxamate compounds, methods for making the same, methods for use as a monotherapy or in combination with one or more other therapeutic agents, for treatment of proliferative diseases such as cancer. The present disclosure also teaches the utilization of said boronic derivatives of hydroxamates as epigenetic therapy medications with enhanced bioavailability, lower-toxicity, and longer-lasting efficacy.
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公开(公告)号：US20200181175A1
公开(公告)日：2020-06-11
申请号：US16463622
申请日：2017-11-27
发明人： Guangdi WANG , Shilong ZHENG , Jiawang LIU , Qiu ZHONG , Shanchun GUO
摘要： The present disclosure relates to boronic derivatives of hydroxamate compounds, methods for making the same, methods for use as a monotherapy or in combination with one or more other therapeutic agents, for treatment of proliferative diseases such as cancer. The present disclosure also teaches the utilization of said boronic derivatives of hydroxamates as epigenetic therapy medications with enhanced bioavailability, lower-toxicity, and longer-lasting efficacy.
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公开(公告)号：US20240158351A1
公开(公告)日：2024-05-16
申请号：US18542220
申请日：2023-12-15
IPC分类号： C07D209/56 , A61K45/06
CPC分类号： C07D209/56 , A61K45/06
摘要： The present disclosure relates to compounds that act as protein kinase inhibitors, especially RPS6K1 and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for proliferative diseases, including cancer, particularly breast cancer, and especially ER+ and/or HER2+ breast cancer, prostate cancer, lung cancer, and metastatic cancer.
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17.发明公开公开(公告)号：US20240010602A1
公开(公告)日：2024-01-11
申请号：US18347724
申请日：2023-07-06
发明人： Rami A. AL-HORANI
IPC分类号： C07C59/90 , C07C69/734 , C07C235/20 , A61P7/02
CPC分类号： C07C59/90 , C07C69/734 , C07C235/20 , A61P7/02
摘要： The present disclosure is directed to compounds having Formula (I) and their enantiomers, wherein the definitions of R, Y1, Y2, W, X, Z, and n are provided in the disclosure. The disclosure is also directed to pharmaceutical compositions of the disclosed compounds, as well as their use for treatment of thrombosis and related conditions and complications.
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公开(公告)号：US09636299B2
公开(公告)日：2017-05-02
申请号：US14388412
申请日：2013-03-15
CPC分类号： A61K9/0048 , A61K38/1709
摘要： Compositions useful for treatment of retinal pathologies, including diabetic retinopathy, and methods of making and using said compositions, are provided.
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19.发明申请BORON-BASED 4-HYDROXYTAMOXIFEN AND ENDOXIFEN PRODRUGS AS TREATMENT FOR BREAST CANCER 有权以硼酸为基础的4-羟基酪氨酸和内切素原料作为乳腺癌治疗公开(公告)号：US20150080339A1
公开(公告)日：2015-03-19
申请号：US14382356
申请日：2013-03-05
发明人： Guangdi Wang , Shilong Zheng , Quan Jiang , Qiu Zhong , Qiang Zhang
IPC分类号： C07F5/02
摘要： The present disclosure relates to boron-based 4-hydroxytamoxifen and endoxifen prodrugs and the synthesis of the same. Further, the present disclosure teaches the utilization of the boron-based 4-hydroxytamoxifen and endoxifen prodrugs in a treatment for breast cancer.
摘要翻译： 本公开内容涉及硼基4-羟基他莫昔芬和内给予药前药及其合成。 此外，本公开内容教导了硼基4-羟基他莫昔芬和内给予前药在乳腺癌治疗中的应用。
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公开(公告)号：US12109510B2
公开(公告)日：2024-10-08
申请号：US17118319
申请日：2020-12-10
CPC分类号： B01D11/0492 , B01D3/10
摘要： Disclosed are methods of solvent removal in an evacuated, closed system at ambient or low (spontaneously dropped due to evaporation endothermicity) temperature. The methods disclosed are suitable for removing the solvents with a broad range of volatility, having normal (STP) boiling points from 30 up to at least 202° C. (vapor pressures at least of 0.1 to 500 torr; higher boiling point solvents are possible to remove with longer experimental times) and is only limited from a volume standpoint by the size of the apparatus used.
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