公开(公告)号：US5675023A

公开(公告)日：1997-10-07

申请号：US469682

申请日：1995-06-06

申请人： Yasushi Igarashi ,  Takuji Yamaguchi ,  Yoshimitsu Ogawa ,  Mika Tomita ,  Hiroko Hayashi ,  Toshitsugu Sato ,  Kunio Hosaka

发明人： Yasushi Igarashi ,  Takuji Yamaguchi ,  Yoshimitsu Ogawa ,  Mika Tomita ,  Hiroko Hayashi ,  Toshitsugu Sato ,  Kunio Hosaka

IPC分类号： C07D311/54 ,  C07D405/12 ,  C07D417/12 ,  C07D405/02 ,  C07D407/12

CPC分类号： C07D405/12 ,  C07D311/54 ,  C07D417/12

摘要： The present invention relates to a chromone derivative and an aldose reductase inhibitor comprising said compound as efective component, which is represented by the following formula: ##STR1## wherein R.sub.1 and R.sub.2 each represent a lower alkyl group, etc., R.sub.3 represents an oxygen atom, a sulfur atom, etc., R.sub.7 represents a phenyl group substituted or not substituted, etc., and R represents a hydrogen atom or a lower alkoxy group. The present compounds exhibit superior inhititory action on aldose reductase and are useful for the treatment of various complications of diseases in diabetes, such as cataract, retinopathy, keratopathy, nephropathy, and neuropathy.

摘要翻译： 本发明涉及色酮衍生物和醛糖还原酶抑制剂，其包含作为有效成分的所述化合物，其由下式表示：其中R 1和R 2各自表示低级烷基等，R 3表示氧原子 ，硫原子等，R7表示取代或未取代的苯基等，R表示氢原子或低级烷氧基。 本发明化合物对醛糖还原酶表现出优异的抑制作用，可用于治疗糖尿病诸如白内障，视网膜病变，角膜病，肾病和神经病变的各种并发症。