公开(公告)号：US11077404B2

公开(公告)日：2021-08-03

申请号：US16743728

申请日：2020-01-15

Applicant: AMGEN INC.

Inventor： Eva Gefroh ,  Randolph W. Schweickart ,  Krista Petty ,  Gregory Frank ,  Christine Salstrom Terpsma ,  Arthur C. Hewig, III ,  Joseph Edward Shultz

IPC: B01D61/22 ,  B01D61/14 ,  B01D61/18 ,  C07K1/34

Abstract: Systems and methods used to control tangential flow filtration are provided, including control systems and methods for use with connected systems with upstream processing units, such as chromatography processing units, in fluid communication with a tangential flow filtration processing unit. Also included are control systems and methods for performing continuous concentration using single-pass tangential flow filtration with permeate flow control.