公开(公告)号：US09803019B2

公开(公告)日：2017-10-31

申请号：US14627992

申请日：2015-02-20

Applicant: Amgen Inc.

Inventor： Kenneth W. Walker ,  Frederick W. Jacobsen ,  Taruna Arora

IPC: C07K16/28 ,  A61K47/48 ,  A61K38/17

CPC classification number: C07K16/2878 ,  A61K38/1767 ,  A61K47/6871 ,  A61K2039/6056 ,  C07K16/18 ,  C07K16/2866 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2319/30

Abstract: Disclosed is an isolated immunoglobulin. Also disclosed are pharmaceutical compositions and medicaments comprising the immunoglobulin, isolated nucleic acid encoding it, vectors, host cells, useful in methods of making it. In some embodiments the immunoglobulin comprises one to twenty-four pharmacologically active chemical moieties conjugated thereto, such as a pharmacologically active polypeptide.

公开(公告)号：US20170015750A1

公开(公告)日：2017-01-19

申请号：US15280662

申请日：2016-09-29

Applicant: AMGEN INC.

Inventor： Shaw-Fen Sylvia HU ,  Ian Nevin FOLTZ ,  Chadwick Terence KING ,  Yang LI ,  Taruna Arora

IPC: C07K16/28

Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) β-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising β-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions.

Abstract translation: 本发明提供与抗原结合蛋白有关或衍生自抗原结合蛋白的组合物和方法激活FGF21介导的信号传导。 在实施方案中，抗原结合蛋白特异性结合（i）β-Klotho; （ii）FGFR1c，FGFR2c，FGFR3c或FGFR4; 或（iii）包含β-Klotho和FGFR1c，FGFR2c，FGFR3c和FGFR4之一的复合物。 在一些实施方案中，抗原结合蛋白诱导FGF21样信号传导。 在一些实施方案中，抗原结合蛋白是完全人，人源化或嵌合抗体，所述抗体的结合片段和衍生物，以及特异性结合（i）β-Klotho的多肽; （ii）FGFR1c，FGFR2c，FGFR3c或FGFR4; 或（iii）包含β-Klotho和FGFR1c，FGFR2c，FGFR3c和FGFR4之一的复合物。 其它实施方案提供了编码这种抗原结合蛋白的核酸及其片段和衍生物，以及多肽，包含这种多核苷酸的细胞，制备此类抗原结合蛋白的方法及其片段和衍生物以及多肽，以及使用这些抗原结合蛋白的方法 ，其片段及其衍生物和多肽，包括治疗或诊断患有2型糖尿病，肥胖症，NASH，代谢综合征和相关疾病或病症的受试者的方法。

公开(公告)号：US09499620B2

公开(公告)日：2016-11-22

申请号：US14497883

申请日：2014-09-26

Applicant: AMGEN INC.

Inventor： Hailing Hsu ,  Ian Foltz ,  Frederick Jacobsen ,  Taruna Arora

IPC: A61K39/395 ,  C07K16/18 ,  C07K16/28

CPC classification number: C07K16/2839 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.

Abstract translation: 公开了alpha4beta7异源二聚体特异性抗原结合蛋白，编码它们的核酸，以及制备和使用它们的方法。

公开(公告)号：US20150086563A1

公开(公告)日：2015-03-26

申请号：US14497883

申请日：2014-09-26

Applicant: AMGEN INC.

Inventor： Hailing Hsu ,  Ian Foltz ,  Frederick Jacobsen ,  Taruna Arora

IPC: C07K16/28

CPC classification number: C07K16/2839 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: There are disclosed alpha4beta7 heterodimer-specific antigen binding proteins, nucleic acids encoding them, and methods of making and using them.

Abstract translation: 公开了alpha4beta7异源二聚体特异性抗原结合蛋白，编码它们的核酸，以及制备和使用它们的方法。