公开(公告)号：US20170218077A1

公开(公告)日：2017-08-03

申请号：US15422619

申请日：2017-02-02

申请人： AMGEN RESEARCH (MUNICH) GMBH ,  AMGEN INC.

发明人： Tobias Raum ,  Markus Münz ,  Johannes Brozy ,  Peter Kufer ,  Patrick Hoffmann ,  Matthias Friedrich ,  Benno Rattel ,  Pamela Bogner ,  Andreas Wolf ,  Cornelius Pompe

IPC分类号： C07K16/28

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/94 ,  C07K2319/00

摘要： The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.