公开(公告)号：US10022351B2

公开(公告)日：2018-07-17

申请号：US15160239

申请日：2016-05-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byung Gyu Kim ,  Hyun Woo Jeong ,  Su Kyung Kim ,  Si Young Cho ,  Chan Woong Park ,  Dae Bang Seo ,  Wan Gi Kim ,  Sang Jun Lee

IPC: A61K31/34 ,  A23L2/52 ,  A61K36/258 ,  A23L33/11 ,  A23L33/105

Abstract: The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.

公开(公告)号：US09999611B2

公开(公告)日：2018-06-19

申请号：US15160197

申请日：2016-05-20

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byung Gyu Kim ,  Hyun Woo Jeong ,  Su Kyung Kim ,  Si Young Cho ,  Chan Woong Park ,  Dae Bang Seo ,  Wan Gi Kim ,  Sang Jun Lee

IPC: A61K31/34 ,  A23L2/52 ,  A61K36/258 ,  A23L33/11 ,  A23L33/105

CPC classification number: A61K31/34 ,  A23L2/52 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K36/258

Abstract: The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.

公开(公告)号：US09913823B2

公开(公告)日：2018-03-13

申请号：US14352444

申请日：2012-10-18

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byung Gyu Kim ,  Hyun Woo Jeong ,  Su Kyung Kim ,  Si Young Cho ,  Chan Woong Park ,  Dae Bang Seo ,  Wan Gi Kim ,  Sang Jun Lee

IPC: A61K31/34 ,  A23L1/30 ,  A61K36/258 ,  A23L33/11 ,  A23L2/52 ,  A23L33/105

CPC classification number: A61K31/34 ,  A23L2/52 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K36/258

Abstract: The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.

公开(公告)号：US09795583B2

公开(公告)日：2017-10-24

申请号：US14437802

申请日：2013-11-29

Applicant: AMOREPACIFIC CORPORATION

Inventor： Si Young Cho ,  Dae Bang Seo ,  Chan Woong Park ,  Wan Gi Kim ,  Sang Jun Lee

IPC: A61K31/34 ,  A23L1/30 ,  A61K31/36 ,  A61K31/05 ,  A23L33/10

CPC classification number: A61K31/34 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/05 ,  A61K31/36

Abstract: The present invention relates to a composition for preventing or treating heart disease, and more particularly, to a composition for preventing or treating heart disease, comprising (+)-syringaresinol. Specifically, (+)-syringaresinol as an active ingredient may exhibit excellent effect of preventing or improving heart disease by promoting SIRT1 expression and suppressing death of cardiomyocytes induced by reactive oxygen species. Accordingly, the composition according to the present disclosure may be used to prevent, improve or treat heart diseases including cardiovascular diseases.

公开(公告)号：US09192597B2

公开(公告)日：2015-11-24

申请号：US14350668

申请日：2012-10-25

Applicant: AMOREPACIFIC CORPORATION

Inventor： Si Young Cho ,  Chan Woong Park ,  Dae Bang Seo ,  Wan Gi Kim ,  Sang Jun Lee

IPC: A01N65/00 ,  A61K31/34 ,  A61K36/00 ,  A23L1/30 ,  A61K36/258 ,  A61K9/00 ,  A61K9/16 ,  A61K9/20 ,  A61K36/185 ,  A61K36/254 ,  A61K36/55 ,  A61K36/756

CPC classification number: A61K31/34 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/1652 ,  A61K9/2059 ,  A61K36/00 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/55 ,  A61K36/756 ,  A23V2200/302 ,  A23V2200/326 ,  A23V2250/21

Abstract: The present invention discloses a composition for inhibiting vascular aging comprising a compound of Chemical formula 1, a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract translation: 本发明公开了一种用于抑制血管衰老的组合物，其包含化学式1的化合物，其衍生物或其药学上可接受的盐作为活性成分。

公开(公告)号：US20140371307A1

公开(公告)日：2014-12-18

申请号：US14352444

申请日：2012-10-18

Applicant: AMOREPACIFIC CORPORATION

Inventor： Byung Gyu Kim ,  Hyun Woo Jeong ,  Su Kyung Kim ,  Si Young Cho ,  Chan Woong Park ,  Dae Bang Seo ,  Wan Gi Kim ,  Sang Jun Lee

IPC: A61K31/34 ,  A23L1/30 ,  A61K36/258

CPC classification number: A61K31/34 ,  A23L2/52 ,  A23L33/105 ,  A23L33/11 ,  A23V2002/00 ,  A61K36/258

Abstract: The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.

Abstract translation: 本发明涉及式1化合物和SIRT 1活化剂，其包括其衍生物或其药学上可接受的盐作为活性成分。 本发明还涉及包含用于解毒的SIRT1激活剂，用于改善代谢紊乱，用于预防或改善眼部疾病或预防或改善免疫疾病的组合物。

公开(公告)号：US20140248381A1

公开(公告)日：2014-09-04

申请号：US14350668

申请日：2012-10-25

Applicant: AMOREPACIFIC CORPORATION

Inventor： Si Young Cho ,  Chan Woong Park ,  Dae Bang Seo ,  Wan Gi Kim ,  Sang Jun Lee

IPC: A61K31/34 ,  A61K36/185 ,  A23L1/30 ,  A61K36/756 ,  A61K36/254 ,  A61K36/55 ,  A61K36/258

CPC classification number: A61K31/34 ,  A23L33/105 ,  A23V2002/00 ,  A61K9/0014 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/1652 ,  A61K9/2059 ,  A61K36/00 ,  A61K36/185 ,  A61K36/254 ,  A61K36/258 ,  A61K36/55 ,  A61K36/756 ,  A23V2200/302 ,  A23V2200/326 ,  A23V2250/21

Abstract: The present invention discloses a composition for inhibiting vascular aging comprising a compound of Chemical formula 1, a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient.

Abstract translation: 本发明公开了一种用于抑制血管衰老的组合物，其包含化学式1的化合物，其衍生物或其药学上可接受的盐作为活性成分。