公开(公告)号：US10995095B2

公开(公告)日：2021-05-04

申请号：US16721076

申请日：2019-12-19

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder

IPC: C07D487/14 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  A61K9/20 ,  A61K9/00

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20180298016A1

公开(公告)日：2018-10-18

申请号：US15954039

申请日：2018-04-16

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Ayman D. Allian ,  Thomas B. Borchardt ,  Jayanthy Jayanth ,  Patrick J. Marroum ,  Fredrik Lars Nordstrom ,  Ahmad Y. Sheikh ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Peter T. Mayer

IPC: C07D487/14 ,  A61K47/38 ,  A61K31/4985 ,  A61K9/00 ,  A61K47/12

CPC classification number: C07D487/14 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.