公开(公告)号：US20220306643A1

公开(公告)日：2022-09-29

申请号：US17827064

申请日：2022-05-27

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder

IPC: C07D487/14 ,  A61K47/38 ,  A61K47/12 ,  A61K31/4985 ,  A61K9/00 ,  A61K9/20

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US11976077B2

公开(公告)日：2024-05-07

申请号：US18176651

申请日：2023-03-01

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Jeffrey W. Voss ,  Robert J. Padley ,  Heidi S. Camp

IPC: C07D487/14 ,  A61K9/00 ,  A61K9/20 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

CPC classification number: C07D487/14 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US11767326B2

公开(公告)日：2023-09-26

申请号：US18176653

申请日：2023-03-01

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder ,  Jeffrey W. Voss ,  Robert J. Padley ,  Heidi S. Camp

IPC: A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07D487/14 ,  A61K9/00 ,  A61K9/20

CPC classification number: C07D487/14 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20230271974A1

公开(公告)日：2023-08-31

申请号：US18176651

申请日：2023-03-01

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Ayman D. Allian ,  Thomas B. Borchardt ,  Jayanthy Jayanth ,  Patrick J. Marroum ,  Fredrik Lars Nordstrom ,  Ahmad Y. Sheikh ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Peter T. Mayer ,  Ben Klünder

IPC: C07D487/14 ,  A61K47/38 ,  A61K47/12 ,  A61K31/4985 ,  A61K9/00 ,  A61K9/20

CPC classification number: C07D487/14 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment(including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US11535626B2

公开(公告)日：2022-12-27

申请号：US17827083

申请日：2022-05-27

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder

IPC: C07D487/14 ,  A61K9/00 ,  A61K9/20 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US11535625B2

公开(公告)日：2022-12-27

申请号：US17827064

申请日：2022-05-27

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder

IPC: C07D487/14 ,  A61K9/00 ,  A61K9/20 ,  A61K31/4985 ,  A61K47/12 ,  A61K47/38

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US10550126B2

公开(公告)日：2020-02-04

申请号：US15954039

申请日：2018-04-16

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder

IPC: A61K31/4985 ,  A61K47/12 ,  A61K47/38 ,  C07D487/14 ,  A61K9/00 ,  A61K9/20

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-α]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20240316042A1

公开(公告)日：2024-09-26

申请号：US18612955

申请日：2024-03-21

Applicant: AbbVie Inc.

Inventor： Mohamed-Eslam F. Mohamed ,  Cheng Thiam Tan ,  Henrique D. Teixeira ,  Alvina D. Chu

IPC: A61K31/4985 ,  A61P17/00 ,  A61P19/02

CPC classification number: A61K31/4985 ,  A61P17/00 ,  A61P19/02

Abstract: The present disclosure is directed to methods for treating disease in pediatric patients with the JAK1 selective inhibitor upadacitinib. The diseases and disorders include idiopathic arthritis (pcJIA), systemic juvenile idiopathic arthritis (SJIA), juvenile psoriatic arthritis (JPsA), atopic dermatitis (AD), juvenile ankylosing spondylitis (JAS), juvenile non-radiographic spondyloarthritis (nr-axSpA), hidradenitis suppurativa (HS), systemic lupus erythematosus (SLE), ulcerative colitis (UC), and Crohn's disease (CD). The treatment methods generally comprise administering to a pediatric patient a therapeutically effective amount of upadacitinib as a stable liquid pharmaceutical composition or a solid dosage form, at a dose based on patient body weight.

公开(公告)号：US20230203050A1

公开(公告)日：2023-06-29

申请号：US18176653

申请日：2023-03-01

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Ayman D. Allian ,  Thomas B. Borchardt ,  Jayanthy Jayanth ,  Patrick J. Marroum ,  Fredrik Lars Nordstrom ,  Ahmad Y. Sheikh ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Peter T. Mayer ,  Ben Klünder

IPC: C07D487/14 ,  A61K47/38 ,  A61K47/12 ,  A61K31/4985 ,  A61K9/00 ,  A61K9/20

CPC classification number: C07D487/14 ,  A61K47/38 ,  A61K47/12 ,  A61K31/4985 ,  A61K9/0053 ,  A61K9/2013 ,  A61K9/2054 ,  A61K9/2027 ,  C07B2200/13

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment(including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.

公开(公告)号：US20220298166A1

公开(公告)日：2022-09-22

申请号：US17827083

申请日：2022-05-27

Applicant: AbbVie Inc.

Inventor： Aileen L. Pangan ,  Henrique D. Teixeira ,  Mohamed-Eslam F. Mohamed ,  Ahmed A. Othman ,  Ben Klünder

IPC: C07D487/14 ,  A61K47/38 ,  A61K47/12 ,  A61K31/4985 ,  A61K9/00 ,  A61K9/20

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3Himidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and atopic dermatitis), kits, methods of synthesis, and products-by-process.