公开(公告)号：US11359028B2

公开(公告)日：2022-06-14

申请号：US16407835

申请日：2019-05-09

申请人： Agenus Inc. ,  Memorial Sloan-Kettering Cancer Center ,  Ludwig Institute for Cancer Research Ltd.

发明人： Nicholas S. Wilson ,  Jeremy D. Waight ,  Dennis J. Underwood ,  Ekaterina V. Breous-Nystrom ,  Gerd Ritter ,  David Schaer ,  Daniel Hirschhorn-Cymerman ,  Taha Merghoub ,  Marc Van Dijk

IPC分类号： C07K16/28 ,  A61K45/06

摘要： The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and/or human GITR receptor (GITR), including multispecific antibodies that bind, e.g., to OX40 and GITR, and compositions comprising such antibodies. The antibodies disclosed herein modulate OX40 and/or GITR activity e.g., enhance, activate, induce, reduce, deactivate, or inhibit OX40 and/or GITR activity. The present disclosure also provides methods for treating disorders, such as cancer, autoimmune diseases or disorders, or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and/or human GITR and modulates OX40 and/or GITR activity.

公开(公告)号：US10259882B2

公开(公告)日：2019-04-16

申请号：US15148720

申请日：2016-05-06

申请人： Agenus Inc. ,  Ludwig Institute for Cancer Research Ltd. ,  Memorial Sloan-Kettering Cancer Center

发明人： Marc Van Dijk ,  Ekaterina V. Breous-Nystrom ,  Gerd Ritter ,  David Schaer ,  Daniel Hirschhorn-Cymerman ,  Taha Merghoub ,  Hao Tang ,  David A. Savitsky ,  Nicholas S. Wilson

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K45/06 ,  G01N33/68 ,  A61K39/00

摘要： The present disclosure provides antibodies that specifically bind to human OX40 receptor (OX40) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human OX40 and modulate OX40 activity, e.g., enhance, activate, or induce OX40 activity, or reduce, deactivate, or inhibit OX40 activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., enhances, activates, or induces OX40 activity. Also provided are methods for treating autoimmune or inflammatory diseases or disorders, by administering an antibody that specifically binds to human OX40 and modulates OX40 activity, e.g., reduces, deactivates, or inhibits OX40 activity.

公开(公告)号：US20150368349A1

公开(公告)日：2015-12-24

申请号：US14724452

申请日：2015-05-28

申请人： 4-Antibody AG ,  Memorial Sloan-Kettering Cancer Center ,  Ludwig Institute for Caner Research Ltd.

发明人： Ana M. GONZALEZ ,  Nicholas S. Wilson ,  Dennis J. Underwood ,  Volker Seibert ,  Olivier Léger ,  Marc van Dijk ,  Roberta Zappasodi ,  Taha Merghoub ,  Jedd David Wolchok ,  David Schaer ,  Gerd Ritter ,  Takemasa Tsuji

IPC分类号： C07K16/28 ,  A61K35/17 ,  A61K45/06 ,  G01N33/50 ,  A61K39/395

CPC分类号： C07K16/2878 ,  A61K35/17 ,  A61K2039/507 ,  C07K16/2809 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/502 ,  G01N2333/70578 ,  Y02A50/386

摘要： The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity.

摘要翻译： 本公开提供了特异性结合人糖皮质激素诱导的TNFR家族相关受体（GITR）的抗体和包含此类抗体的组合物。 在具体方面，抗体与人GITR特异性结合并利用这种抗体调节GITR活性，例如增强，激活或诱导GITR活性。 本公开还提供了通过施用特异性结合人GITR并调节GITR活性的抗体（例如增强，激活或诱导GITR活性）来治疗疾病如癌症和感染性疾病的方法。