公开(公告)号：US20240361300A1

公开(公告)日：2024-10-31

申请号：US18660389

申请日：2024-05-10

申请人： JRD SCIENCE, INC.

发明人： Christina Rae-Kyung LEE

IPC分类号： G01N33/50 ,  G01N33/68

CPC分类号： G01N33/5023 ,  G01N33/505 ,  G01N33/6896 ,  G01N2333/4703 ,  G01N2333/70578 ,  G01N2333/745 ,  G01N2800/24 ,  G01N2800/28

摘要： The present invention relates to a biomarker for regulatory T cells.

公开(公告)号：US12091465B2

公开(公告)日：2024-09-17

申请号：US16637357

申请日：2018-08-14

申请人： Seoul National University R&DB Foundation

发明人： Doo Hyun Chung ,  Eugene C. Yi ,  Dongjin Jeong ,  Min Jueng Kang ,  Donghyun Kim

IPC分类号： C07K14/705 ,  A61P19/02 ,  C07K14/71 ,  C07K16/28 ,  C12N15/113 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/2878 ,  A61P19/02 ,  C07K14/70578 ,  C07K14/70596 ,  C12N15/113 ,  C12N15/1138 ,  G01N33/6872 ,  A61K2039/505 ,  C12N2310/11 ,  C12N2310/14 ,  G01N2333/70578

摘要： The present invention relates to a composition for preventing or treating diseases caused by overexpression of chemokine CX3CL1 (fractalkine) comprising a death receptor 5 (DR5) inhibitor as an active ingredient, a method for preventing or treating diseases caused by overexpression of chemokine CX3CL1 comprising administering a DR5 expression or activity inhibitor to a patient in need of prevention or treatment of diseases caused by overexpression of chemokine CX3CL1 in a therapeutically effective amount, and a use for prevention or treatment of diseases caused by overexpression of chemokine CX3CL1 of a DR5 expression or activity inhibitor.

公开(公告)号：US20240210396A1

公开(公告)日：2024-06-27

申请号：US18285912

申请日：2022-04-08

申请人： Achilles Therapeutics UK Limited

发明人： Katy Newton ,  Sergio Quezada

IPC分类号： G01N33/569 ,  A61K35/17

CPC分类号： G01N33/56972 ,  A61K35/17 ,  G01N2333/525 ,  G01N2333/55 ,  G01N2333/57 ,  G01N2333/70578 ,  G01N2333/70596

摘要： The present invention relates to a batch release assay for pharmaceutical products relating to T cell therapies. Said T cells therapies are particularly useful for treating or preventing cancer in a subject.

公开(公告)号：US20240168038A1

公开(公告)日：2024-05-23

申请号：US18283652

申请日：2022-03-25

申请人： RANDOX LABORATORIES ,  RANDOX TEORANTA

发明人： Ivan McConnell ,  Peter Fitzgerald ,  John Lamont ,  Ciaran Richarson ,  Matthew Griffin

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/4716 ,  G01N2333/70578 ,  G01N2800/347 ,  G01N2800/52

摘要： The current invention provides methods which can be implemented alongside clinical variables as risk prediction tools for improved prediction of CKD progression and mortality. Surprisingly it was found that decreased C3a-desArg was associated with adverse outcome in CKD, and when combined with increased STNFR1 and NGAL it gave an excellent predictor of progression to a composite endpoint in CKD patients.

公开(公告)号：US11912777B2

公开(公告)日：2024-02-27

申请号：US18064061

申请日：2022-12-09

申请人： Nanjing Leads Biolabs Co., Ltd.

发明人： Xiaoqiang Kang ,  Shoupeng Lai ,  Xiao Huang ,  Huan Lin ,  Yujia Dang

IPC分类号： C07K16/28 ,  A61P1/00 ,  A61P35/00 ,  G01N33/68 ,  A61K39/00

CPC分类号： C07K16/2878 ,  A61P1/00 ,  A61P35/00 ,  C07K16/2818 ,  G01N33/6863 ,  A61K2039/505 ,  A61K2039/507 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/74 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/70578

摘要： The present invention relates to a novel antibody and antibody fragment that specifically binds to TNFR2 and to a composition comprising said antibody or antibody fragment. In addition, the present invention relates to a nucleic acid encoding the antibody or an antibody fragment thereof and a host cell comprising the same, and to a related use thereof. Besides, the present invention relates to the use of the antibody and antibody fragment for treatment and diagnosis.

公开(公告)号：US20230288430A1

公开(公告)日：2023-09-14

申请号：US17923161

申请日：2021-05-04

申请人： Etablissement Français du Sang ,  UNIVERSITE JEAN MONNET SAINT ETIENNE MAISON DE L'UNIVERSITE 10 RUE TREFILERIE 42100 SAINT-ETIENNE

发明人： Fabrice COGNASSE ,  Thi Kim Anh NGUYEN-PEYRE ,  Olivier GARRAUD ,  Hind HAMZEH-COGNASSE

IPC分类号： G01N33/68

CPC分类号： G01N33/6893 ,  G01N2333/70596 ,  G01N2333/912 ,  G01N2333/523 ,  G01N2333/70578 ,  G01N2800/52 ,  G01N2800/56 ,  G01N2800/7095

摘要： The present invention relates to a method for detecting inflammation-related platelet activation, comprising measuring the quantity, concentration and/or the proportion of seven specific biomarkers representative of 47 intra-platelet, soluble and membrane molecules, in a biological sample. Said panel of seven biomarkers is particularly useful for implementing a method of diagnosing inflammation-related platelet activation in an individual, a method for monitoring the efficacy of a curative or preventive treatment of an inflammatory disease in an individual and/or a method for monitoring the development of an inflammatory disease associated with inflammation-related platelet activation in an individual.
The present invention also relates to a kit for detecting inflammation-related platelet activation, as well as the use thereof.

公开(公告)号：US11725059B2

公开(公告)日：2023-08-15

申请号：US17173716

申请日：2021-02-11

申请人： MEMORIAL SLOAN KETTERING CANCER CENTER ,  EUREKA THERAPEUTICS, INC.

发明人： Renier J. Brentjens ,  Eric L. Smith ,  Cheng Liu

IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K14/705 ,  A61K47/68 ,  A61P35/00 ,  G01N33/68

CPC分类号： C07K16/2878 ,  A61K47/6849 ,  A61P35/00 ,  C07K14/70575 ,  C07K16/2896 ,  G01N33/6863 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2319/21 ,  C07K2319/30 ,  C07K2319/42 ,  G01N2333/70578

摘要： The presently disclosed subject matter provides antibodies that bind to B-cell maturation antigen (BCMA) and methods of using the same.

公开(公告)号：US20180208670A1

公开(公告)日：2018-07-26

申请号：US15669418

申请日：2017-08-04

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Holbrook Kohrt ,  Roch Houot ,  Ronald Levy ,  Arash Ash Alizadeh ,  Matthew J. Goldstein ,  James Torchia

IPC分类号： C07K16/28

CPC分类号： C07K16/2896 ,  A61K2039/507 ,  C07K16/2863 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/2893 ,  C07K16/3015 ,  C07K16/3023 ,  C07K16/3046 ,  C07K16/3069 ,  C07K16/32 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/75 ,  G01N33/57492 ,  G01N2333/70578

摘要： Methods are provided to enhance the efficacy of antibody therapy directed to tumor cells.

公开(公告)号：US20180208666A1

公开(公告)日：2018-07-26

申请号：US15921254

申请日：2018-03-14

申请人： Spring BioScience Corporation

发明人： Yifei Zhu ,  Zhiming Liao ,  Robert Pytela

IPC分类号： C07K16/28 ,  G01N33/574

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/626 ,  G01N33/574 ,  G01N2333/70578

摘要： The invention provides antibodies immunoreactive with human OX40 and methods of using the same. The antibodies are reactive with a portion of the C-terminus of the human OX40 protein that includes amino acids 266-277. The antibodies are useful for detecting OX40 protein expression in human tissue samples, including by immunohistochemistry, immunofluorescence, or immunoblot.

公开(公告)号：US20180016346A1

公开(公告)日：2018-01-18

申请号：US15541872

申请日：2016-01-08

申请人： KYOWA HAKKO KIRIN CO., LTD

发明人： Nobuaki TAKAHASHI ,  Makoto NAKAYAMA ,  Sayaka TAKAGI

IPC分类号： C07K16/30 ,  C07K16/28 ,  G01N33/574

CPC分类号： C07K16/3069 ,  A61K39/395 ,  C07K16/28 ,  C07K16/2878 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C12N5/10 ,  C12N15/09 ,  G01N33/57492 ,  G01N2333/70578 ,  G01N2333/948

摘要： The present invention is related to a bispecific antibody or an antibody fragment thereof comprising an antigen binding domain that binds to a TRAILR2, and an antigen binding domain that binds to a PSMA; a nucleic acid comprising a nucleotide sequence that encodes the antibody or the antibody fragment thereof; a recombinant vector comprising the nucleic acid; a transformant comprising the recombinant vector; a method for producing the bispecific antibody or the antibody fragment thereof by using the transformant; and a reagent for detection or measurement, a diagnostic agent, and a therapeutic agent, each of which comprises the bispecific antibody or the antibody fragment thereof.