公开(公告)号：US20240000965A1

公开(公告)日：2024-01-04

申请号：US18354436

申请日：2023-07-18

Applicant: Ajinomoto Co., Inc.

Inventor： Noriko HATADA ,  Kei YAMADA ,  Yutaka MATSUDA ,  Tomohiro FUJII

IPC: A61K47/68

CPC classification number: A61K47/6889 ,  A61K47/6811

Abstract: Compounds and salts thereof represented by the following formula (I):






wherein
X indicates a leaving group,
Y indicates an affinity peptide having a binding region to a CH2 domain in an immunoglobulin unit containing two heavy chains and two light chains,
O indicates an oxygen atom,
S indicates a sulfur atom,
W indicates an oxygen atom or a sulfur atom,
La indicates a first linker,
Lb indicates a second linker, and
the total number of atoms constituting a main chain in the first linker and atoms constituting a main chain in the second linker are 5 to 7, facilitate regioselective modification of an antibody with a functional substance and control of the bonding ratio of the antibody to the functional substance within a desired range.