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公开(公告)号：US12121042B2
公开(公告)日：2024-10-22
申请号：US18147860
申请日：2022-12-29
申请人： AJINOMOTO CO., INC.
发明人： Sachiko Yonemaru , Koji Haga , Yuki Miyazawa , Susumu Shibahara
IPC分类号： A23K20/142 , A23K20/158 , A23K20/174 , A23K40/25 , A23K40/35 , A23K50/10 , A61K31/198 , A61K31/405 , A61K31/455 , A61K31/519 , A61K31/714
CPC分类号： A23K20/142 , A23K20/158 , A23K20/174 , A23K40/35 , A23K50/10 , A61K31/198 , A61K31/405 , A61K31/455 , A61K31/519 , A61K31/714 , A23K40/25
摘要： Dispersion type feed additive compositions for ruminants, containing
(A) at least one selected from hydrogenated vegetable oil and hydrogenated animal oil each having a melting point of higher than 50° C. and lower than 90° C.,
(B) not less than 0.01 wt % and not more than 6 wt % of a surfactant,
(C) not less than 16 wt % and not more than 72 wt % of a biologically active substance (excluding L-lysine and a salt thereof), and
(D) not less than 1 wt % and not more than 40 wt % of L-lysine or a salt thereof,
contain a biologically active substance at a high concentration, show high protection in the rumen, and are also superior in dissolution in the intestinal tract.-
公开(公告)号：US20240269311A1
公开(公告)日：2024-08-15
申请号：US18619756
申请日：2024-03-28
申请人： Ajinomoto Co., Inc.
CPC分类号： A61K47/6811 , C07K5/08 , C07K16/46
摘要： A regioselective conjugate of an antibody and a functional substance comprising a structural unit represented by the following Formula (I):
wherein
Ig represents an immunoglobulin unit comprising two heavy chains and two light chains, and is regioselectively bonded to L1 adjacent to Ig via an amino group in side chains of lysine residues in the two heavy chains,
HG represents a hydrophilic group,
RA represents a side chain of a valine residue,
RB represents a side chain of a citrulline residue or the like,
ring A represents a divalent aromatic ring group optionally having a substituent,
R1 and R2 each independently represent a hydrogen atom or a monovalent group,
L1 and L2 each independently represent a divalent
D represents a functional substance, and
r is 1.5 to 2.5, or
a salt thereof, and
substances related thereto,
is excellent in desired properties while controlling a bonding ratio between the antibody and the functional substance within a specific range.-
公开(公告)号：US20240254328A1
公开(公告)日：2024-08-01
申请号：US18583637
申请日：2024-02-21
申请人： Ajinomoto Co., Inc.
发明人： Shohei FUJISHIMA , Shu IKEHIRA
CPC分类号： C08L63/00 , C08L35/02 , C08L71/12 , H05K1/0346 , C08L2203/20 , C08L2205/03
摘要： Resin compositions including (A) a compound containing a radical polymerizable group having a carbodiimide structure, and at least any one of (B) a compound containing a radical polymerizable group not having a carbodiimide structure and (C) a thermosetting resin can afford a cured product having excellent mechanical strength and plating adhesion property.
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公开(公告)号：US20240225053A9
公开(公告)日：2024-07-11
申请号：US18392322
申请日：2023-12-21
申请人： AJINOMOTO CO., INC.
发明人： Akinori UEHARA , Yasuteru SAKAMOTO
IPC分类号： A23K20/22 , A23K20/158 , A23K20/163 , A61K9/00 , A61K9/16 , A61K33/20 , A61K47/36 , A61P31/04
CPC分类号： A23K20/22 , A23K20/158 , A23K20/163 , A61K9/0056 , A61K9/1617 , A61K33/20 , A61K47/36 , A61P31/04
摘要： The present invention provides a sporulation inhibitor of Clostridium perfringens containing at least one inorganic compound at a concentration that allows Clostridium perfringens to settle in vivo, wherein the inorganic compound is at least one salt selected from the group consisting of K, Na, Mg, Ca, and Fe, and the inorganic compound is coated with a protective layer containing hydrogenated vegetable oil.
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公开(公告)号：US20240219394A1
公开(公告)日：2024-07-04
申请号：US18432550
申请日：2024-02-05
申请人： AJINOMOTO CO., INC.
发明人： Chiori IJICHI , Yusuke IHARA , Yasuko SOMEKAWA , Yayoi KAWATO , Sachise KARAKAWA
CPC分类号： G01N33/68 , G01N33/74 , G01N2333/726 , G01N2500/04 , G01N2500/10
摘要： A method for measuring a response of an olfactory receptor to a substance is provided. The test substance and the olfactory receptor are contacted under such a condition that response of adenosine receptor to the test substance is reduced, and response of the olfactory receptor to the test substance is measured.
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公开(公告)号：US12024549B2
公开(公告)日：2024-07-02
申请号：US16663791
申请日：2019-10-25
申请人： Ajinomoto Co., Inc.
发明人： Kei Yamada , Yutaka Matsuda , Tomohiro Fujii , Natsuki Shikida , Reiko Yuji , Kazutaka Shimbo , Yuji Ito
CPC分类号： C07K16/00 , C07K19/00 , C07K2317/52
摘要： The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I):
A-L-B-R (I)
wherein
A is an affinity substance to a soluble protein;
L is a cleavable linker which is a divalent group comprising a cleavable portion;
B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and
R is a reactive group to the soluble protein; or
a salt thereof.-
公开(公告)号：US20240182862A1
公开(公告)日：2024-06-06
申请号：US18533804
申请日：2023-12-08
申请人： AJINOMOTO CO., INC.
发明人： Kazuma TAKAHASHI , Shizuka BABA , Atsushi KONISHI
IPC分类号： C12N5/0775 , A61K35/28 , A61P1/16 , C07K14/47
CPC分类号： C12N5/0668 , A61K35/28 , A61P1/16 , C07K14/4718 , C12N2500/90 , C12N2501/39 , C12N2506/08 , C12N2506/45 , C12N2533/52
摘要： A medicament for the prophylaxis or treatment of inflammatory diseases or fibrous diseases, may be produced by inducing mesenchymal stem cells by culturing neural crest cells in a medium composition for inducing mesenchymal stem cells from neural crest cells, comprising a basal medium and corticosteroid, the composition having a converted concentration of the corticosteroid in the medium composition of not less than 1.25 μM.
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公开(公告)号：US20240130403A1
公开(公告)日：2024-04-25
申请号：US18392322
申请日：2023-12-21
申请人： AJINOMOTO CO., INC.
发明人： Akinori UEHARA , Yasuteru SAKAMOTO
IPC分类号： A23K20/22 , A23K20/158 , A23K20/163 , A61K9/00 , A61K9/16 , A61K33/20 , A61K47/36 , A61P31/04
CPC分类号： A23K20/22 , A23K20/158 , A23K20/163 , A61K9/0056 , A61K9/1617 , A61K33/20 , A61K47/36 , A61P31/04
摘要： The present invention provides a sporulation inhibitor of Clostridium perfringens containing at least one inorganic compound at a concentration that allows Clostridium perfringens to settle in vivo, wherein the inorganic compound is at least one salt selected from the group consisting of K, Na, Mg, Ca, and Fe, and the inorganic compound is coated with a protective layer containing hydrogenated vegetable oil.
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公开(公告)号：US20240034874A1
公开(公告)日：2024-02-01
申请号：US18466987
申请日：2023-09-14
申请人： Ajinomoto Co., Inc.
发明人： Shu IKEHIRA
CPC分类号： C08L63/00 , C08J5/18 , C08K3/013 , C08K5/0025 , H05K1/0326 , C08K2201/003
摘要： A resin sheet including a support and a resin composition layer formed on the support, in which the resin composition layer contains (A) an epoxy resin, (B) an organic solvent, (C) an inorganic filler, and (D) a stress relaxing material, in which a content of an aromatic solvent having a boiling point of lower than 120° C. in the (B) component is in the range of 0 to 9% by mass relative to 100% by mass of total of the (B) component, can suppress an irregularity after lamination and a warpage after curing.
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公开(公告)号：US11884814B2
公开(公告)日：2024-01-30
申请号：US17179866
申请日：2021-02-19
申请人： AJINOMOTO CO., INC.
发明人： Masatoshi Watanabe
IPC分类号： C08L63/00 , C08L9/00 , C09D109/00 , C09D163/00 , C08L33/08 , H05K1/03 , C09D133/08
CPC分类号： C08L63/00 , C08L9/00 , C08L33/08 , C09D109/00 , C09D133/08 , C09D163/00 , H05K1/032 , C08L2201/02 , C08L2205/025 , C08L2205/035 , C08L2205/20 , C08L63/00 , C08K7/22 , C08L71/00
摘要： Resin compositions including (A) a hollow organic polymer particle, (B) an epoxy resin, and (C) a curing agent provide cured products having a superior smear removal properties.
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