公开(公告)号：US5861411A

公开(公告)日：1999-01-19

申请号：US629901

申请日：1996-04-10

申请人： Kunihiro Ninomiya, deceased ,  Ken-ichi Saito ,  Mamoru Sugano ,  Akihiro Tobe ,  Yasuhiro Morinaka ,  Tomoko Bessho ,  Haruko Harada

发明人： Kunihiro Ninomiya, deceased ,  Ken-ichi Saito ,  Mamoru Sugano ,  Akihiro Tobe ,  Yasuhiro Morinaka ,  Tomoko Bessho ,  Haruko Harada

IPC分类号： C07D219/10 ,  C07D221/16 ,  C07D221/20 ,  C07D221/22 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/44

CPC分类号： C07D221/20 ,  C07D219/10 ,  C07D221/16 ,  C07D221/22 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04

摘要： A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.

摘要翻译： 公开了由下式（I）表示的新型4-酰氨基吡啶衍生物。 （I）本发明的4-酰基氨基吡啶衍生物作为治疗老年性痴呆和阿尔茨海默氏病等记忆障碍的药物是有用的，因为它具有直接激活故障胆碱能神经元的作用。

公开(公告)号：US5536728A

公开(公告)日：1996-07-16

申请号：US355181

申请日：1994-12-08

申请人： Kunihiro Ninomiya, deceased ,  Ken-ichi Saito ,  Mamoru Sugano ,  Akihiro Tobe ,  Yasuhiro Morinaka ,  Tomoko Bessho ,  Haruko Harada

发明人： Kunihiro Ninomiya, deceased ,  Ken-ichi Saito ,  Mamoru Sugano ,  Akihiro Tobe ,  Yasuhiro Morinaka ,  Tomoko Bessho ,  Haruko Harada

IPC分类号： C07D219/10 ,  C07D221/16 ,  C07D221/20 ,  C07D221/22 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D495/04 ,  A61K31/44

CPC分类号： C07D221/20 ,  C07D219/10 ,  C07D221/16 ,  C07D221/22 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D495/04

摘要： A novel 4-acylaminopyridine derivative represented by the following formula (I) is disclosed. ##STR1## The 4-acylaminopyridine derivative of the present invention is useful as a medicine for treating disturbances of memory such as senile dementia and Alzheimer's disease, since it has an action of directly activating malfunctioned cholinergic neuron.

公开(公告)号：US4143040A

公开(公告)日：1979-03-06

申请号：US853424

申请日：1977-11-21

申请人： Tadashi Oohama ,  Ryozo Yamaguchi ,  Mamoru Sugano

发明人： Tadashi Oohama ,  Ryozo Yamaguchi ,  Mamoru Sugano

IPC分类号： C07J1/00 ,  C07J21/00 ,  C07J75/00 ,  C07J17/00

CPC分类号： C07J21/008 ,  C07J1/0081

摘要： 17-Ketals of 3-alkoxyestra-2,5(10)-dien-17-ones are prepared by reacting 17-ketals of 3-alkoxyestra-1,3,5(10)-trien-17-ones with sodium or potassium, liquid ammonia and a tertiary alcohol in the presence of an alicyclic hydrocarbon and/or an aliphatic hydrocarbon, and a solvent selected from the group consisting of tetrahydrofuran, dioxane and tetrahydropyran.Yield and selectivity of this reaction are improved by using the 17-ketal of the 3-alkoxyestra-1,3,5(10)-trien-17-one, sodium or potassium, liquid ammonia and the solvent in such proportions that the 17-ketal of the 3-alkoxyestra-1,3,5(10)-trien-17-one is substantially dissolved in the reaction system and that two liquid phases are formed, the lower phase being colored.