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    Antagonists of miRNA-29 Expression and Their Use in the Prevention and Treatment of Aneurysm
    11.
    发明申请
    Antagonists of miRNA-29 Expression and Their Use in the Prevention and Treatment of Aneurysm 有权
    miRNA-29表达的拮抗剂​​及其在预防和治疗动脉瘤中的应用

    公开(公告)号：US20130116303A1

    公开(公告)日：2013-05-09

    申请号：US13637924

    申请日：2011-04-01

    申请人： Andreas Zeiher ,  Stefanie Dimmeler ,  Reinier Boon

    发明人： Andreas Zeiher ,  Stefanie Dimmeler ,  Reinier Boon

    IPC分类号： C12N15/113 ,  C12Q1/02

    CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12Q1/025

    摘要： The present invention relates to antagonists of the expression and/or the function of the micro RNA miRNA-29 for use in the prevention and/or treatment of aortic aneurysms. Further disclosed is a method for the identification of miRNA-29 antagonists, a pharmaceutical composition comprising said miRNA-29 antagonists and a method for preventing and treating age-related aortic aneurysm formation in a subject in need of such a treatment.

    摘要翻译： 本发明涉及用于预防和/或治疗主动脉瘤的微RNA miRNA-29的表达和/或功能的拮抗剂。 进一步公开的是鉴定miRNA-29拮抗剂的方法，包含所述miRNA-29拮抗剂的药物组合物以及预防和治疗需要这种治疗的受试者中与年龄有关的主动脉瘤形成的方法。

    In vitro method for the diagnosis of cardiovascular functionality of bone marrow precursor cells (BMPS) and/or blood-derived circulating precursor cells (BDPS)
    12.
    发明授权
    In vitro method for the diagnosis of cardiovascular functionality of bone marrow precursor cells (BMPS) and/or blood-derived circulating precursor cells (BDPS) 有权
    用于诊断骨髓前体细胞（BMPS）和/或血液循环前体细胞（BDPS）的心血管功能的体外方法

    公开(公告)号：US07919315B2

    公开(公告)日：2011-04-05

    申请号：US10574380

    申请日：2004-10-13

    申请人： Andreas M. Zeiher ,  Christopher Heeschen ,  Stefanie Dimmeler

    发明人： Andreas M. Zeiher ,  Christopher Heeschen ,  Stefanie Dimmeler

    IPC分类号： C12N5/08

    CPC分类号： G01N33/56966 ,  A61K2035/124 ,  G01N33/5005 ,  G01N2333/70589 ,  G01N2333/70596 ,  G01N2333/71 ,  G01N2333/755

    摘要： The present invention relates to an in vitro method for the analysis of a sample from a mammal in connection with cardiovascular diseases, wherein the method comprises the following steps: a) isolating of bone marrow-precursor cells (BMPs) and/or blood-derived circulating precursor cells (BDPs) by means of cell specific surface markers, and b) detecting the cardiovascular functionality of the isolated BMPs and/or BDPs by means of a suitable migration assay. The method according to the invention can be employed as a kit in the context of the diagnosis and/or the prognosis of cardiovascular diseases, for the monitoring of their therapies and/or for a stratification for a prospective cell therapy with stem- and/or precursor cells in order to increase the perfusion of ischemic tissue or for a regeneration of tissue losses (e.g. heart insufficiency), respectively. In a further aspect, the present invention then relates to an in vitro method for isolating specific bone marrow-precursor cells by means of a suitable migration assay. According to the invention, these BMPs and/or BDPs can be used for the treatment of cardiovascular diseases, selected from the group consisting of stable coronary heart disease, acute coronary syndrome, acute myocardial infarction, chronic ischemic cardiomyopathy (ICMP), dilatative cardiomyopathy (DCM) or other causes for a heart insufficiency.

    摘要翻译： 本发明涉及用于分析哺乳动物与心血管疾病相关的样品的体外方法，其中所述方法包括以下步骤：a）分离骨髓前体细胞（BMP）和/或血液来源的 通过细胞特异性表面标志物循环前体细胞（BDP），和b）通过合适的迁移试验检测分离的BMP和/或BDP的心血管功能。 根据本发明的方法可以在心血管疾病的诊断和/或预后的背景下用作试剂盒，用于监测其疗法和/或用于具有茎和/或血管的前瞻性细胞治疗的分层， 为了增加缺血组织的灌注或组织损失（例如心脏功能不全）的再生，分别为前体细胞。 在另一方面，本发明涉及通过合适的迁移试验分离特异性骨髓前体细胞的体外方法。 根据本发明，这些BMP和/或BDP可用于治疗心血管疾病，其选自稳定性冠心病，急性冠状动脉综合征，急性心肌梗死，慢性缺血性心肌病（ICMP），扩张性心肌病 DCM）或心脏功能不全的其他原因。

    Micro-RNA for the regulation of cardiac apoptosis and contractile function
    16.
    发明授权
    Micro-RNA for the regulation of cardiac apoptosis and contractile function 有权
    微RNA用于调节心脏细胞凋亡和收缩功能

    公开(公告)号：US08871731B2

    公开(公告)日：2014-10-28

    申请号：US13422932

    申请日：2012-03-16

    申请人： Stefanie Dimmeler ,  Reinier A. Boon ,  Ariane Fischer ,  Andreas M. Zeiher

    发明人： Stefanie Dimmeler ,  Reinier A. Boon ,  Ariane Fischer ,  Andreas M. Zeiher

    IPC分类号： C12N15/11 ,  A61K31/7125 ,  C12N15/113 ,  A61K31/712

    CPC分类号： A61K31/712 ,  A61K31/7125 ,  C12N15/113 ,  C12N2310/113

    摘要： The present invention relates to treating or preventing age-related cardiomyopathy by modulating the expression or activity of a miR-34 family member and/or PNUTS. Methods of treating or preventing age-related cardiomyopathy include administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity. Also provided herein are methods of treating or preventing cardiac fibrosis and myocardial infarction by administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity.

    摘要翻译： 本发明涉及通过调节miR-34家族成员和/或PNUTS的表达或活性来治疗或预防年龄相关性心肌病。 治疗或预防年龄相关性心肌病的方法包括施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂。 本文还提供了通过施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂来治疗或预防心脏纤维化和心肌梗死的方法。

    Method for promoting angiogenesis, vascularization or vessel repair
    17.
    发明授权
    Method for promoting angiogenesis, vascularization or vessel repair 有权
    促进血管生成，血管化或血管修复的方法

    公开(公告)号：US08258113B2

    公开(公告)日：2012-09-04

    申请号：US12739876

    申请日：2008-10-30

    申请人： Stefanie Dimmeler ,  Andreas M. Zeiher ,  Angelika Bonauer ,  Carmen Urbich

    发明人： Stefanie Dimmeler ,  Andreas M. Zeiher ,  Angelika Bonauer ,  Carmen Urbich

    IPC分类号： C12N15/11 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12N2320/50

    摘要： The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein the construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.

    摘要翻译： 本发明涉及一种影响细胞中miR-92表达的方法，包括以下步骤：（a）提供细胞; 和（b1）通过将针对miR-92的反义分子引入细胞来促进血管形成或血管修复，或（b2）增加细胞中miR-92的表达， 通过将构建体引入细胞来抑制肿瘤血管发生，其中构建体包含可表达的miR-92序列。 此外，本发明涉及药物组合物，其包含用于降低miR-92的反义分子形式的细胞中的miR-92活性或表达的试剂或用于增加细胞中miR-92表达的试剂 以用于表达miR-92的构建体的形式。

    Method for treating myocardial infarct
    18.
    发明授权
    Method for treating myocardial infarct 有权
    心肌梗死的治疗方法

    公开(公告)号：US08912158B2

    公开(公告)日：2014-12-16

    申请号：US13569786

    申请日：2012-08-08

    申请人： Stefanie Dimmeler ,  Andreas M. Zeiher ,  Angelika Bonauer ,  Carmen Urbich

    发明人： Stefanie Dimmeler ,  Andreas M. Zeiher ,  Angelika Bonauer ,  Carmen Urbich

    IPC分类号： C12N15/11 ,  C12N15/113 ,  C07H21/04

    CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12N2320/50

    摘要： The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.

    摘要翻译： 本发明涉及一种影响细胞中miR-92表达的方法，包括以下步骤：（a）提供细胞; 和（b1）通过将针对miR-92的反义分子引入细胞来促进血管形成或血管修复，或（b2）增加细胞中miR-92的表达， 通过将构建体导入细胞来抑制肿瘤血管生成，其中所述构建体包括可表达的miR-92序列。 此外，本发明涉及药物组合物，其包含用于降低miR-92的反义分子形式的细胞中miR-92活性或表达的试剂或用于增加细胞中miR-92表达的试剂 以用于表达miR-92的构建体的形式。

    Method for Promoting Angiogenesis, Vascularization, or Vessel Repair or for the Inhibiting Tumor Angiogenesis
    19.
    发明申请
    Method for Promoting Angiogenesis, Vascularization, or Vessel Repair or for the Inhibiting Tumor Angiogenesis 有权
    促进血管生成，血管化或血管修复或抑制肿瘤血管生成的方法

    公开(公告)号：US20120322856A1

    公开(公告)日：2012-12-20

    申请号：US13569786

    申请日：2012-08-08

    申请人： Stefanie Dimmeler ,  Andreas M. Zeiher ,  Angelika Bonauer ,  Carmen Urbich

    发明人： Stefanie Dimmeler ,  Andreas M. Zeiher ,  Angelika Bonauer ,  Carmen Urbich

    IPC分类号： A61K31/7088 ,  A61P9/10 ,  A61P25/28 ,  A61P25/16 ,  C12N5/078 ,  A61P29/00 ,  C12N5/07 ,  C12N5/0789 ,  C12N5/077 ,  C12N5/0793 ,  C07H21/02 ,  A61P35/00

    CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12N2320/50

    摘要： The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.

    摘要翻译： 本发明涉及一种影响细胞中miR-92表达的方法，包括以下步骤：（a）提供细胞; 和（b1）通过将针对miR-92的反义分子引入细胞来促进血管形成或血管修复，或（b2）增加细胞中miR-92的表达， 通过将构建体导入细胞来抑制肿瘤血管生成，其中所述构建体包括可表达的miR-92序列。 此外，本发明涉及药物组合物，其包含用于降低miR-92的反义分子形式的细胞中miR-92活性或表达的试剂或用于增加细胞中miR-92表达的试剂 以用于表达miR-92的构建体的形式。

    Method for the Promotion of Angiogenesis, Vascularization, or Vascular Repair or for the Inhibition of Tumor Angiogenesis
    20.
    发明申请
    Method for the Promotion of Angiogenesis, Vascularization, or Vascular Repair or for the Inhibition of Tumor Angiogenesis 有权
    促进血管生成，血管形成或血管修复或抑制肿瘤血管生成的方法

    公开(公告)号：US20100324118A1

    公开(公告)日：2010-12-23

    申请号：US12739876

    申请日：2008-10-30

    申请人： Stefanie Dimmeler ,  Andreas M. Zeiher ,  Angelika Bonauer ,  Carmen Urbich

    发明人： Stefanie Dimmeler ,  Andreas M. Zeiher ,  Angelika Bonauer ,  Carmen Urbich

    IPC分类号： A61K31/7105 ,  C12N5/07 ,  A61K31/7088 ,  C12N5/079 ,  C12N5/078 ,  C07H21/02 ,  A61P9/10 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00

    CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N2310/113 ,  C12N2320/50

    摘要： The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.

    摘要翻译： 本发明涉及一种影响细胞中miR-92表达的方法，包括以下步骤：（a）提供细胞; 和（b1）通过将针对miR-92的反义分子引入细胞来促进血管形成或血管修复，或（b2）增加细胞中miR-92的表达， 通过将构建体导入细胞来抑制肿瘤血管发生，其中所述构建体包含可表达的miR-92序列。 此外，本发明涉及药物组合物，其包含用于降低miR-92的反义分子形式的细胞中miR-92活性或表达的试剂或用于增加细胞中miR-92表达的试剂 以用于表达miR-92的构建体的形式。