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    MICRO-RNA FOR THE REGULATION OF CARDIAC APOPTOSIS AND CONTRACTILE FUNCTION
    1.
    发明申请
    MICRO-RNA FOR THE REGULATION OF CARDIAC APOPTOSIS AND CONTRACTILE FUNCTION 有权
    用于调节心脏病和合并功能的微RNA

    公开(公告)号：US20120238619A1

    公开(公告)日：2012-09-20

    申请号：US13422932

    申请日：2012-03-16

    申请人： Stefanie DIMMELER ,  Reinier A. Boon ,  Ariane Fischer ,  Andreas M. Zeiher

    发明人： Stefanie DIMMELER ,  Reinier A. Boon ,  Ariane Fischer ,  Andreas M. Zeiher

    IPC分类号： A61K31/7088 ,  A61P9/10 ,  A61P9/00

    CPC分类号： A61K31/712 ,  A61K31/7125 ,  C12N15/113 ,  C12N2310/113

    摘要： The present invention relates to treating or preventing age-related cardiomyopathy by modulating the expression or activity of a miR-34 family member and/or PNUTS. Methods of treating or preventing age-related cardiomyopathy include administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity. Also provided herein are methods of treating or preventing cardiac fibrosis and myocardial infarction by administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity.

    摘要翻译： 本发明涉及通过调节miR-34家族成员和/或PNUTS的表达或活性来治疗或预防年龄相关性心肌病。 治疗或预防年龄相关性心肌病的方法包括施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂。 本文还提供了通过施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂来治疗或预防心脏纤维化和心肌梗死的方法。

    Micro-RNA for the regulation of cardiac apoptosis and contractile function
    2.
    发明授权
    Micro-RNA for the regulation of cardiac apoptosis and contractile function 有权
    微RNA用于调节心脏细胞凋亡和收缩功能

    公开(公告)号：US08871731B2

    公开(公告)日：2014-10-28

    申请号：US13422932

    申请日：2012-03-16

    申请人： Stefanie Dimmeler ,  Reinier A. Boon ,  Ariane Fischer ,  Andreas M. Zeiher

    发明人： Stefanie Dimmeler ,  Reinier A. Boon ,  Ariane Fischer ,  Andreas M. Zeiher

    IPC分类号： C12N15/11 ,  A61K31/7125 ,  C12N15/113 ,  A61K31/712

    CPC分类号： A61K31/712 ,  A61K31/7125 ,  C12N15/113 ,  C12N2310/113

    摘要： The present invention relates to treating or preventing age-related cardiomyopathy by modulating the expression or activity of a miR-34 family member and/or PNUTS. Methods of treating or preventing age-related cardiomyopathy include administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity. Also provided herein are methods of treating or preventing cardiac fibrosis and myocardial infarction by administering an inhibitor of miR-34 expression or activity or an agonist of PNUTS expression or activity.

    摘要翻译： 本发明涉及通过调节miR-34家族成员和/或PNUTS的表达或活性来治疗或预防年龄相关性心肌病。 治疗或预防年龄相关性心肌病的方法包括施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂。 本文还提供了通过施用miR-34表达或活性的抑制剂或PNUTS表达或活性的激动剂来治疗或预防心脏纤维化和心肌梗死的方法。