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11.发明申请Microparticle Formulations for Delivery to the Upper and Central Respiratory Tract and Methods of Manufacture 审中-公开用于输送上呼吸道和中呼吸道的微粒配方及其制造方法公开(公告)号：US20140154308A1
公开(公告)日：2014-06-05
申请号：US13931401
申请日：2013-06-28
发明人： Tiejun Li , Brian Thome
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K9/1623 , A61K38/47 , C07K14/001
摘要： Microparticle formulations are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
摘要翻译： 通过使蛋白质或其它活性剂的水溶液与有机溶剂，抗衡离子和清除剂接触并使溶液冷却来制备微粒制剂。 微粒可用于制备具有预定尺寸的稳定的均匀药物。
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12.发明申请Microparticle Formulations for Delivery to the Lower and Central Respiratory Tract and Methods of Manufacture 审中-公开用于输送到下呼吸道和中央呼吸道的微粒制剂及其制造方法公开(公告)号：US20140099380A1
公开(公告)日：2014-04-10
申请号：US13931419
申请日：2013-06-28
发明人： Michael P. Malakhov , Tiejun Li
CPC分类号： A61K38/47 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1682 , A61K38/18 , C07K14/36 , C07K2319/00 , C12Y302/01018
摘要： Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
摘要翻译： 唾液酸酶融合蛋白的微粒制剂通过使蛋白质或其它活性剂的水溶液与有机溶剂，抗衡离子和清除剂接触并使溶液冷却而产生。 微粒可用于制备具有预定尺寸的稳定的均匀药物。
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