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1.发明申请Microparticle Formulations for Delivery to the Lower and Central Respiratory Tract and Methods of Manufacture 有权用于输送到下呼吸道和中央呼吸道的微粒制剂及其制造方法公开(公告)号：US20160324941A1
公开(公告)日：2016-11-10
申请号：US15156268
申请日：2016-05-16
发明人： Michael P. Malakhov , Tiejun Li
CPC分类号： A61K38/47 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1682 , A61K38/18 , C07K14/36 , C07K2319/00 , C12Y302/01018
摘要： Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
摘要翻译： 唾液酸酶融合蛋白的微粒制剂通过使蛋白质或其它活性剂的水溶液与有机溶剂，抗衡离子和清除剂接触并使溶液冷却而产生。 微粒可用于制备具有预定尺寸的稳定的均匀药物。
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2.发明申请公开(公告)号：US20130280332A1
公开(公告)日：2013-10-24
申请号：US13770991
申请日：2013-02-19
发明人： Ronald D. Moss , Tiejun Li
IPC分类号： A61K38/47
CPC分类号： A61K38/47 , A61K9/0073 , C12Y302/01018
摘要： A method of reducing or treating parainfluenza or influenza virus infection in an immunocompromised patient by administering to the respiratory tract of the patient a composition comprising a therapeutically effective amount of protein having sialidase activity.
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3.发明申请公开(公告)号：US20170312346A1
公开(公告)日：2017-11-02
申请号：US15645520
申请日：2017-07-10
发明人： Michael P. Malakhov , Tiejun Li
CPC分类号： A61K38/47 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1682 , A61K38/18 , C07K14/36 , C07K2319/00 , C12Y302/01018
摘要： Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
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4.发明申请Methods, Compounds and Compositions for Treatment of Influenza and Parainfluenza Patients 审中-公开方法，用于治疗流感和副流感病毒的化合物和组合物公开(公告)号：US20150132274A1
公开(公告)日：2015-05-14
申请号：US14605572
申请日：2015-01-26
发明人： Ronald D Moss , Tiejun Li
CPC分类号： A61K38/47 , A61K9/0073 , C12Y302/01018
摘要： A method of reducing or treating parainfluenza or influenza virus infection in an immunocompromised patient by administering to the respiratory tract of the patient a composition comprising a therapeutically effective amount of protein having sialidase activity.
摘要翻译： 一种在免疫受损的患者中通过向患者的呼吸道施用包含治疗有效量的具有唾液酸酶活性的蛋白质的组合物来减少或治疗副流感或流感病毒感染的方法。
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5.发明申请公开(公告)号：US20200164048A1
公开(公告)日：2020-05-28
申请号：US16505597
申请日：2019-07-08
发明人： Michael P Malakhov , Tiejun Li
摘要： Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
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6.发明申请公开(公告)号：US20170151315A1
公开(公告)日：2017-06-01
申请号：US15430288
申请日：2017-02-10
发明人： Ronald D Moss , Tiejun Li
CPC分类号： A61K38/47 , A61K9/0073 , C12Y302/01018
摘要： A method of reducing or treating parainfluenza or influenza virus infection in an immunocompromised patient by administering to the respiratory tract of the patient a composition comprising a therapeutically effective amount of protein having sialidase activity.
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公开(公告)号：US20140342006A1
公开(公告)日：2014-11-20
申请号：US14209350
申请日：2014-03-13
发明人： Tiejun Li
CPC分类号： A61K9/1641 , A61K9/0019 , A61K9/1617 , A61K9/1623 , A61K9/1694 , A61K38/47 , A61K47/10
摘要： A method for preparing a microparticle suspension, which comprises: (a) providing protein microparticles having a median diameter between 5 and 13 microns and a GSD less than 2.5; (b) combining the microparticles with a liquid, pharmaceutically acceptable, water miscible media to create a first mixture; (c) adding an aqueous media to the first mixture to create second mixture; and (d) mixing the second mixture to create a microparticle suspension is described. The suspension are injectable even when they contain a relatively high concentration of protein.
摘要翻译： 一种制备微粒悬浮液的方法，其包括：（a）提供中值粒径在5和13微米之间的蛋白质微粒，GSD小于2.5; （b）将微粒与液体，药学上可接受的水混溶媒体组合以产生第一混合物; （c）向第一混合物中加入水性介质以产生第二混合物; 和（d）混合第二混合物以产生微粒悬浮液。 即使它们含有相对高浓度的蛋白质，该悬浮液也是可注射的。
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公开(公告)号：US20210353719A1
公开(公告)日：2021-11-18
申请号：US17210408
申请日：2021-03-23
发明人： Michael P. Malakhov , Tiejun Li
摘要： Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
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9.发明申请公开(公告)号：US20210046165A1
公开(公告)日：2021-02-18
申请号：US16945776
申请日：2020-07-31
发明人： Ronald B Moss , Tiejun Li
摘要： A method of reducing or treating parainfluenza or influenza virus infection in an immunocompromised patient by administering to the respiratory tract of the patient a composition comprising a therapeutically effective amount of protein having sialidase activity.
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公开(公告)号：US09700602B2
公开(公告)日：2017-07-11
申请号：US15156268
申请日：2016-05-16
发明人： Michael P. Malakhov , Tiejun Li
CPC分类号： A61K38/47 , A61K9/0075 , A61K9/1611 , A61K9/1617 , A61K9/1623 , A61K9/1682 , A61K38/18 , C07K14/36 , C07K2319/00 , C12Y302/01018
摘要： Microparticle formulations of a sialidase fusion protein are produced by contacting an aqueous solution of a protein or other active agent with an organic solvent, a counterion and a scavenging agent, and chilling the solution. The microparticles are useful for preparing stable, uniform pharmaceuticals of predetermined defined dimensions.
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