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![SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS](/abs-image/US/2017/04/27/US20170114069A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170114069A1
公开(公告)日：2017-04-27
申请号：US15401895
申请日：2017-01-09
Applicant: Array BioPharma, Inc.
Inventor： Shelley Allen , Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Kercher , Jeongbeob Seo
IPC: C07D487/04
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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公开(公告)号：US20150336970A1
公开(公告)日：2015-11-26
申请号：US14575663
申请日：2014-12-18
Applicant: Array BioPharma Inc.
Inventor： Steven Wade Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
IPC: C07D487/22 , C07D471/22
CPC classification number: C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases
Abstract translation: 式I化合物及其药学上可接受的盐，其中环A，环B，W，m，D，R2，R2a，R3，R3a和Z如本文所定义，是Trk激酶的抑制剂，可用于治疗 疼痛，癌症，炎症，神经变性疾病和某些传染病
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![Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors](/abs-image/US/2017/10/24/US09796724B2/abs.jpg.150x150.jpg)
公开(公告)号：US09796724B2
公开(公告)日：2017-10-24
申请号：US15401895
申请日：2017-01-09
Applicant: Array BioPharma, Inc.
Inventor： Shelley Allen , Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Kercher , Jeongbeob Seo
IPC: A01N43/90 , A61K31/519 , C07D487/00 , C07D487/04
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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公开(公告)号：US20170107232A1
公开(公告)日：2017-04-20
申请号：US15350888
申请日：2016-11-14
Applicant: Array BioPharma, Inc.
Inventor： Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
IPC: C07D498/22 , C07D471/22
CPC classification number: C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a R3 and R3a are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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公开(公告)号：US09493476B2
公开(公告)日：2016-11-15
申请号：US14575663
申请日：2014-12-18
Applicant: Array BioPharma Inc.
Inventor： Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
IPC: C07D487/22 , A61K31/519 , C07D487/04 , C07D519/00 , C07D471/22 , C07D498/22
CPC classification number: C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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Patent Agency Ranking
公开(公告)号：US20200291026A1
公开(公告)日：2020-09-17
申请号：US16818125
申请日：2020-03-13
Applicant: Array BioPharma Inc.
Inventor： Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
IPC: C07D471/22 , C07D498/22
Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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公开(公告)号：US20170283435A1
公开(公告)日：2017-10-05
申请号：US15632187
申请日：2017-06-23
Applicant: Array BioPharma, Inc.
Inventor： Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
IPC: C07D498/22 , C07D487/22 , C07D471/22
CPC classification number: C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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公开(公告)号：US20170112842A1
公开(公告)日：2017-04-27
申请号：US15401952
申请日：2017-01-09
Applicant: Array BioPharma, Inc.
Inventor： Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Yutong Jiang , Gabrielle R. Kolakowski , Jeongbeob Seo , Hong-Woon Yang , Qian Zhao
IPC: A61K31/529
CPC classification number: C07D498/22 , A61K31/519 , C07D471/22 , C07D487/04 , C07D487/22 , C07D519/00
Abstract: Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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![Substituted Pyrazolo [1,5-A] Pyrimidine Compounds as TRK Kinase Inhibitors](/abs-image/US/2015/01/29/US20150031667A1/abs.jpg.150x150.jpg)
19.发明申请Substituted Pyrazolo [1,5-A] Pyrimidine Compounds as TRK Kinase Inhibitors 有权取代的吡唑并[1,5-A]嘧啶化合物作为TRK激酶抑制剂公开(公告)号：US20150031667A1
公开(公告)日：2015-01-29
申请号：US14321246
申请日：2014-07-01
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Steven Wade Andrews , Kevin Ronald Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Krecher , Jeongbeob Seo
IPC: C07D487/04 , C07D453/02
CPC classification number: C07D487/04 , A61K31/519 , A61K31/5377 , C07D453/02 , C07D471/22 , C07D498/22 , C07D519/00
Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
Abstract translation: 式Ⅰ化合物及其盐，其中R1，R2，R3，R4，X，Y和n具有本说明书中给出的含义，是Trk激酶的抑制剂，可用于治疗可用 Trk激酶抑制剂如疼痛，癌症，炎症，神经变性疾病和某些传染病。
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![Substituted pyrazolo[l,5-a]pyrimidine compounds as Trk kinase inhibitors](/abs-image/US/2020/09/01/US10758542B2/abs.jpg.150x150.jpg)
公开(公告)号：US10758542B2
公开(公告)日：2020-09-01
申请号：US16377514
申请日：2019-04-08
Applicant: Array BioPharma Inc.
Inventor： Shelley Allen , Steven W. Andrews , Kevin Ronald Condroski , Julia Haas , Lily Huang , Yutong Jiang , Timothy Kercher , Jeongbeob Seo
IPC: A61K31/519 , C07D519/00 , C07D487/04 , C07D453/02 , C07D471/22 , C07D498/22 , A61K31/5377
Abstract: Compounds of Formula I: and salts thereof in which R1, R2, R3, R4, X, Y and n have the meanings given in the specification, are inhibitors of Trk kinases and are useful in the treatment of diseases which can be treated with a Trk kinase inhibitor such as pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.
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