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公开(公告)号：US20170231963A1
公开(公告)日：2017-08-17
申请号：US15445393
申请日：2017-02-28
Applicant: Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K9/00 , A61K9/20 , A61K45/06
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：US20160168104A1
公开(公告)日：2016-06-16
申请号：US15053441
申请日：2016-02-25
Applicant: Novartis Pharma AG , Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/08
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro -3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Abstract translation: 本发明涉及制备6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺的方法， （4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺，以及有用的中间体。 本文还提供包含该结晶化合物的药物组合物。
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公开(公告)号：US20160168102A1
公开(公告)日：2016-06-16
申请号：US14974588
申请日：2015-12-18
Applicant: Array BioPharma, Inc. , Novartis Pharma AG
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , C30B29/54 , C30B7/08
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Abstract translation: 本发明涉及制备6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺的方法， （4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺，以及有用的中间体。 本文还提供包含该结晶化合物的药物组合物。
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公开(公告)号：US09238627B2
公开(公告)日：2016-01-19
申请号：US14057498
申请日：2013-10-18
Applicant: Novartis AG , Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , A61K47/26 , A61K47/38 , A61K9/20
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Abstract translation: 本发明涉及制备6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺的方法， （4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺，以及有用的中间体。 本文还提供包含该结晶化合物的药物组合物。
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公开(公告)号：US10729678B2
公开(公告)日：2020-08-04
申请号：US16512823
申请日：2019-07-16
Applicant: Array BioPharma Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , A61K31/4184 , A61K9/20 , A61K9/00 , C07D235/08 , A61K47/12 , A61K47/02 , C30B29/54 , C30B7/08 , A61K47/38 , A61K47/26 , A61K45/06
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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Patent Agency Ranking
公开(公告)号：US20200171002A1
公开(公告)日：2020-06-04
申请号：US16512823
申请日：2019-07-16
Applicant: Array BioPharma Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K45/06 , A61K9/20 , A61K9/00 , C07D235/08 , A61K47/12 , A61K47/02 , C30B29/54 , C30B7/08 , C07D235/06 , A61K47/38 , A61K47/26
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：US20180296533A1
公开(公告)日：2018-10-18
申请号：US15842715
申请日：2017-12-14
Applicant: Array BioPharma Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: A61K31/4184 , A61K45/06 , A61K47/26 , A61K9/20 , A61K9/00 , C07D235/08 , C07D235/06 , A61K47/12 , A61K47/02 , C30B29/54 , C30B7/08 , A61K47/38
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
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公开(公告)号：US09562016B2
公开(公告)日：2017-02-07
申请号：US14974655
申请日：2015-12-18
Applicant: Novartis AG , Array BioPharma, Inc.
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , A61K9/20 , C30B7/08 , C30B29/54 , C07D235/08
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Abstract translation: 本发明涉及制备6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺的方法， （4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺，以及有用的中间体。 本文还提供包含该结晶化合物的药物组合物。
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公开(公告)号：US20140128442A1
公开(公告)日：2014-05-08
申请号：US14057498
申请日：2013-10-18
Applicant: Array BioPharma, Inc. , Novartis AG
Inventor： Christoph Max Krell , Marian Misun , Daniel Andreas Niederer , Werner Heinz Pachinger , Marie-Christine Wolf , Daniel Zimmermann , Weidong Liu , Peter J. Stengel , Paul Nichols
IPC: C07D235/06 , A61K47/38 , A61K47/26
CPC classification number: A61K31/4184 , A61K9/0053 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/38 , C07B2200/13 , C07D235/06 , C07D235/08 , C30B7/08 , C30B29/54
Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.
Abstract translation: 本发明涉及制备6-（4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺的方法， （4-溴-2-氟苯基氨基）-7-氟-3-甲基-3H-苯并咪唑-5-甲酸（2-羟基乙氧基） - 酰胺，以及有用的中间体。 本文还提供包含该结晶化合物的药物组合物。
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20.发明授权公开(公告)号：US09790206B2
公开(公告)日：2017-10-17
申请号：US14770035
申请日：2014-02-27
Applicant: Array BioPharma Inc.
Inventor： C. Todd Eary , Bruno P. Hache , Derrick Juengst , Stacey Renee Spencer , Peter J. Stengel , Daniel John Watson
IPC: C07D403/12 , C07D231/56
CPC classification number: C07D403/12 , C07D231/56
Abstract: Provided herein are novel processes for preparing a compound of Formula (I) to the use of said compound as an intermediate in novel processes for the synthesis of indazole derivatives, and to indazole intermediates and derivatives prepared by the processes described herein.
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