公开(公告)号：US20240270701A1

公开(公告)日：2024-08-15

申请号：US18694362

申请日：2022-09-22

申请人： Curasen Therapeutics, Inc.

发明人： Jiaxin Yu ,  Anthony P. Ford ,  Wei Chen

IPC分类号： C07D241/42 ,  A61K31/4045 ,  A61K31/416 ,  A61K31/417 ,  A61K31/426 ,  A61K31/437 ,  A61K31/44 ,  A61K31/47 ,  A61K31/498 ,  A61K31/517 ,  C07D209/34 ,  C07D213/38 ,  C07D213/61 ,  C07D213/73 ,  C07D215/14 ,  C07D215/233 ,  C07D231/56 ,  C07D235/08 ,  C07D235/26 ,  C07D237/20 ,  C07D239/42 ,  C07D239/74 ,  C07D277/40 ,  C07D277/68 ,  C07D471/04

CPC分类号： C07D241/42 ,  A61K31/4045 ,  A61K31/416 ,  A61K31/417 ,  A61K31/426 ,  A61K31/437 ,  A61K31/44 ,  A61K31/47 ,  A61K31/498 ,  A61K31/517 ,  C07D209/34 ,  C07D213/38 ,  C07D213/61 ,  C07D213/73 ,  C07D215/14 ,  C07D215/233 ,  C07D231/56 ,  C07D235/08 ,  C07D235/26 ,  C07D237/20 ,  C07D239/42 ,  C07D239/74 ,  C07D277/40 ,  C07D277/68 ,  C07D471/04

摘要： The present disclosure is directed to chemical compounds and to the use of such compounds in the treatment of diseases associated with an adrenergic receptor. An advantage of the compounds provided herein is that a broad range of pharmacological activities is possible, consistent with modulation of beta-adrenergic receptors. In addition, the disclosure provides methods of using the compounds described herein for the treatment of diseases associated with an adrenergic receptor, including but not limited to neurodegenerative diseases and disorders.

公开(公告)号：US20240081146A1

公开(公告)日：2024-03-07

申请号：US18218597

申请日：2023-07-06

申请人： LG Display Co., Ltd.

发明人： Yu-Jeong LEE ,  Jung-Keun KIM ,  Mi-Young HAN ,  Min-Hyeong HWANG

IPC分类号： H10K85/60 ,  C07D235/08 ,  C07D471/10 ,  C09K11/06

CPC分类号： H10K85/6572 ,  C07D235/08 ,  C07D471/10 ,  C09K11/06 ,  H10K85/615 ,  H10K85/626 ,  H10K50/166

摘要： An organic light emitting diode (OLED) includes an emissive layer with at least one emitting part includes at least one emitting material layer, a first electron transport layer and a second electron transport layer disposed sequentially between two facing electrodes, wherein the first electron transport layer includes a first electron transporting material of a benzimidazole-based compound substituted with at least one spiro-structured fluorenyl group and the second electron transport layer includes a second electron transporting material of a benzimidazole-based compound substituted with at least one anthracenyl group. The first electron transport including the first electron transport material with excellent thermal stability is disposed adjacently to the emitting material layer so that the OLED can maintain good luminescent intensity in an environment of high temperature and implement beneficial luminous properties.

公开(公告)号：US20230348398A1

公开(公告)日：2023-11-02

申请号：US17996321

申请日：2021-04-14

申请人： Hoffmann-La Roche Inc.

发明人： Guido GALLEY ,  Katrin GROEBKE ZBINDEN ,  Daniel HUNZIKER ,  Wolfgang GUBA ,  Stefan BERCHTOLD ,  Danny KRUMM ,  Daniela KRUMMENACHER ,  Manuel HILBERT

IPC分类号： C07D235/08 ,  C07D235/30 ,  C07D235/10 ,  C07D235/14 ,  C07D401/06 ,  C07D403/06

CPC分类号： C07D235/08 ,  C07D235/30 ,  C07D235/10 ,  C07D235/14 ,  C07D401/06 ,  C07D403/06

摘要： The invention relates to a compound of formula (I) wherein R1-R4 are as defined in the description and in the claims. The compound of formula (I) can be used as a medicament.

公开(公告)号：US11752128B2

公开(公告)日：2023-09-12

申请号：US17385194

申请日：2021-07-26

申请人： MERCK SHARP & DOHME CORP.

发明人： John P. Caldwell ,  Ginny Dai Ho ,  Sookhee N. Ha ,  Sandra J. Koseoglu ,  Marc A. Labroli ,  Sang Ho Lee ,  Christina Madsen-Duggan ,  Mihir Mandal ,  Jianping Pan ,  Weidong Pan ,  Terry Roemer ,  Jing Su ,  Christopher Michael Tan ,  Zheng Tan ,  Hao Wang ,  Christine Yang ,  Shu-Wei Yang

IPC分类号： A61K31/397 ,  A61P31/04 ,  A61K31/407 ,  C07D235/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D471/04

CPC分类号： A61K31/397 ,  A61K31/407 ,  A61P31/04 ,  C07D235/08 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D471/04

摘要： Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a β-lactam antibiotic.

公开(公告)号：US20190241587A1

公开(公告)日：2019-08-08

申请号：US16384178

申请日：2019-04-15

申请人： California Institute Of Technology

发明人： Anton Toutov ,  Kerry Betz ,  Andrew M. Romine ,  Robert H. Grubbs

IPC分类号： C07F7/18 ,  C07F7/08 ,  C07F7/21 ,  C07D235/08

CPC分类号： C07F7/1804 ,  C07D235/08 ,  C07F7/0896 ,  C07F7/21

摘要： The present disclosure is directed to methods for dehydrogenatively coupled hydrosilanes and alcohols, the methods comprising contacting an organic substrate having at least one organic alcohol moiety with a mixture of at least one hydrosilane and sodium and/or potassium hydroxide, the contacting resulting in the formation of a dehydrogenatively coupled silyl ether. The disclosure further described associated compositions and methods of using the formed products.

公开(公告)号：US20190240357A1

公开(公告)日：2019-08-08

申请号：US16213358

申请日：2018-12-07

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： Jacob M. Hooker ,  Changning Wang ,  Frederick Albert Schroeder

IPC分类号： A61K51/04 ,  C07D267/16 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07D281/12 ,  C07D209/14 ,  C07D209/08 ,  C07C259/06 ,  C07D235/08 ,  C07C311/21

CPC分类号： A61K51/04 ,  C07B2200/05 ,  C07C259/06 ,  C07C259/08 ,  C07C275/34 ,  C07C311/16 ,  C07C311/21 ,  C07C2601/14 ,  C07C2602/10 ,  C07C2603/74 ,  C07D209/08 ,  C07D209/14 ,  C07D235/08 ,  C07D267/16 ,  C07D281/12

摘要： Disclosed herein are histone deacetylase imaging agents for positron emission tomography and related imaging methods using the histone deacetylase imaging agents. The histone deacetylase imaging agents may be a compound of formula (I): wherein R1 is a moiety including a positron emitter; R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and n is an integer selected from 0 or 1. In one version of the compound of formula (I), R1 is a moiety including an adamantyl group.

公开(公告)号：US10074809B2

公开(公告)日：2018-09-11

申请号：US15509178

申请日：2015-10-27

申请人： LG CHEM, LTD.

发明人： Boonjae Jang ,  Jungl Jang ,  Seong So Kim ,  Dong Hoon Lee

IPC分类号： H01L51/00 ,  C07D401/10 ,  C07C255/50 ,  C07D209/86 ,  C07D235/02 ,  C07D235/08 ,  C07D239/26 ,  C07D251/24 ,  C07D263/57 ,  C07D277/66 ,  C09K11/02 ,  C07D403/10 ,  C07D403/14 ,  H01L51/50 ,  C09K11/06 ,  H01L51/52

CPC分类号： H01L51/0062 ,  C07C255/50 ,  C07D209/86 ,  C07D235/02 ,  C07D235/08 ,  C07D239/26 ,  C07D251/24 ,  C07D263/57 ,  C07D277/66 ,  C07D401/10 ,  C07D403/10 ,  C07D403/14 ,  C09K11/025 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  H01L51/0052 ,  H01L51/0054 ,  H01L51/0056 ,  H01L51/0058 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0064 ,  H01L51/0067 ,  H01L51/0069 ,  H01L51/0071 ,  H01L51/0072 ,  H01L51/50 ,  H01L51/5012 ,  H01L51/5072 ,  H01L51/5092 ,  H01L51/5206 ,  H01L51/5221

摘要： An exemplary embodiment of the present specification provides an organic electroluminescence device including: an anode; a cathode; a light emitting layer provided between the anode and the cathode; and an electron transporting layer provided between the cathode and the light emitting layer, in which the electron transporting layer includes a first electron transporting material and a second electron transporting material, the first electron transporting material is an organic material including a monocyclic or polycyclic ring which includes an N-containing six-membered ring, the second electron transporting material is an organic material including a five-membered hetero ring which includes at least one heteroatom of N, O, and S, or a cyano group, and a dipole moment of the second electron transporting material is larger than a dipole moment of the first electron transporting material.

公开(公告)号：US09981901B2

公开(公告)日：2018-05-29

申请号：US15356292

申请日：2016-11-18

申请人： FOSUN ORINOVE PHARMATECH, INC.

发明人： John B. Patterson ,  David G. Lonergan ,  Gary A. Flynn ,  Qingping Zeng ,  Peter V. Pallai

IPC分类号： C07C235/42 ,  A61K31/166 ,  C07C65/21 ,  C07C65/26 ,  C07C65/11 ,  C07C233/65

CPC分类号： C07C65/21 ,  A61K31/11 ,  A61K31/135 ,  A61K31/166 ,  A61K31/192 ,  A61K31/357 ,  A61K31/381 ,  A61K31/505 ,  A61K31/5375 ,  A61K31/5377 ,  C07C47/55 ,  C07C47/565 ,  C07C47/575 ,  C07C65/11 ,  C07C65/26 ,  C07C65/30 ,  C07C205/44 ,  C07C205/61 ,  C07C223/02 ,  C07C233/65 ,  C07C235/42 ,  C07C235/84 ,  C07C251/24 ,  C07C317/24 ,  C07C321/04 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07D213/48 ,  C07D213/64 ,  C07D213/69 ,  C07D213/74 ,  C07D215/14 ,  C07D217/16 ,  C07D231/12 ,  C07D235/08 ,  C07D239/26 ,  C07D239/54 ,  C07D241/18 ,  C07D249/18 ,  C07D261/08 ,  C07D277/34 ,  C07D295/125 ,  C07D295/15 ,  C07D295/192 ,  C07D307/80 ,  C07D317/54 ,  C07D319/08 ,  C07D319/18 ,  C07D321/10 ,  C07D333/22 ,  C07D333/58 ,  C07D401/12 ,  C07D403/12 ,  C07D417/10 ,  Y02A50/389 ,  Y02A50/393

摘要： Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

公开(公告)号：US20180130959A1

公开(公告)日：2018-05-10

申请号：US15866616

申请日：2018-01-10

申请人： IDEMITSU KOSAN CO., LTD.

发明人： Toshinari OGIWARA ,  Kei YOSHIDA ,  Ryohei HASHIMOTO ,  Yumiko MIZUKI

IPC分类号： H01L51/00 ,  C07D307/91 ,  C07D405/14 ,  C07D487/14 ,  C09K11/06 ,  H01L51/50 ,  C07D235/08 ,  C07D403/14

CPC分类号： H01L51/0072 ,  C07D235/08 ,  C07D307/91 ,  C07D403/14 ,  C07D405/14 ,  C07D487/14 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1014 ,  C09K2211/1029 ,  C09K2211/1059 ,  C09K2211/1088 ,  C09K2211/1092 ,  C09K2211/1096 ,  H01L51/0052 ,  H01L51/0054 ,  H01L51/0056 ,  H01L51/006 ,  H01L51/0067 ,  H01L51/0071 ,  H01L51/0073 ,  H01L51/0074 ,  H01L51/0094 ,  H01L51/5004 ,  H01L51/5016 ,  H01L51/5028 ,  H01L51/5056 ,  H01L51/5064 ,  H01L51/5072 ,  H01L51/5088 ,  H01L51/5092 ,  H01L51/5096 ,  H01L2251/55

摘要： An organic electroluminescence device includes: an anode; an emitting layer; and a cathode, the emitting layer containing a first material, a second material and a third material, the first material being a fluorescent material, the second material being a delayed fluorescent material, the third material having a singlet energy larger than a singlet energy of the second material.

公开(公告)号：US09956214B2

公开(公告)日：2018-05-01

申请号：US15351525

申请日：2016-11-15

申请人： UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION

发明人： Erkang Fan ,  Wesley C. Van Voorhis ,  Zhongsheng Zhang ,  Wenlin Huang ,  Kayode K. Ojo

IPC分类号： A61K31/4709 ,  C07D311/20 ,  C07D231/38 ,  C07D235/08 ,  C07D235/12 ,  C07D487/04 ,  C07D231/14 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/5377

CPC分类号： A61K31/4709 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/5377 ,  C07D231/14 ,  C07D231/38 ,  C07D235/08 ,  C07D235/12 ,  C07D311/20 ,  C07D401/04 ,  C07D401/06 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D487/04 ,  Y02A50/488

摘要： The present disclosure is generally directed to compositions and methods for treating apicomplexan protozoan related disease, such as toxoplasmosis and cryptosporidiosis.