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271 条记录 (耗时 0.037 秒)

    Device for administering active agent to biological environment
    11.
    发明授权
    Device for administering active agent to biological environment 失效
    将活性剂投与生物环境的装置

    公开(公告)号：US5417682A

    公开(公告)日：1995-05-23

    申请号：US186046

    申请日：1994-01-21

    申请人： Patrick S. L. Wong ,  Felix Theeuwes ,  Steven D. Larsen ,  Liang C. Dong

    发明人： Patrick S. L. Wong ,  Felix Theeuwes ,  Steven D. Larsen ,  Liang C. Dong

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/48

    CPC分类号： A61K9/0004 ,  A61K9/4808

    摘要： The present invention is directed to a fluid-imbibing dispensing device for the immediate or almost immediate and extended delivery of an active agent over a prolonged period of time together with the initially delayed pulse delivery of an active agent to a fluid environment of use. The dispenser comprises a housing having a first wall section and a second wall section in slidably telescoping arrangement with each other, which housing maintains its integrity in the environment of use; an internal compartment surrounded and defined by the housing; a first active agent delivery chamber within a portion of the compartment defined by the first wall section, the first delivery chamber including at least one active agent formulation, an exit means for providing communication between the active agent formulation and the environment, and a first expansion means for dispensing the first active agent formulation through the exit means to the environment immediately and over a prolonged period of time; a second active agent delivery chamber within a portion of the compartment defined by the first wall section and adjacent the open end of the first wall section, the second delivery chamber including at least one active agent formulation; and an expansion chamber within a portion of the compartment defined by the second wall section, for separating apart the first and second wall sections of the housing after exposure to the environment of use for dispensing the second active agent formulation to the environment in a pulse after an initially delayed period of time, the expansion chamber including a second expansion means and a partition layer or push plate.

    摘要翻译： 本发明涉及一种流体吸入分配装置，用于在延长的时间段内立即或几乎立即和延长地递送活性剂，同时将活性剂的初始延迟脉冲输送到使用的流体环境。 分配器包括具有彼此可滑动地伸缩布置的第一壁部分和第二壁部分的壳体，该壳体在使用环境中保持其完整性; 由壳体包围和限定的内部隔室; 第一活性剂递送室，位于由第一壁部限定的隔室的一部分内，第一递送室包括至少一种活性剂制剂，用于提供活性剂配方与环境之间的连通的出口装置，以及第一膨胀 用于通过出口装置将第一活性剂制剂直接和长时间地分配到环境的装置; 第二活性剂递送室，其在由第一壁部分限定并且邻近第一壁部分的开口端限定的隔室的一部分内，第二递送室包括至少一种活性剂制剂; 以及在由所述第二壁部限定的所述隔室的一部分内的膨胀室，用于在暴露于使用环境之后分离所述壳体的所述第一和第二壁部分，以在所述第二活性剂配方的环境中以脉冲分配所述环境 最初延迟的时间段，膨胀室包括第二膨胀装置和分隔层或推板。

    Delayed onset transdermal delivery device
    13.
    发明授权
    Delayed onset transdermal delivery device 失效
    延迟发作透皮递送装置

    公开(公告)号：US5284660A

    公开(公告)日：1994-02-08

    申请号：US933423

    申请日：1992-08-21

    申请人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Robert M. Gale ,  Alejandro Zaffaroni

    发明人： Eun Soo Lee ,  Felix Theeuwes ,  Patrick S. L. Wong ,  Su Il Yum ,  Robert M. Gale ,  Alejandro Zaffaroni

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/70 ,  A61F13/00

    CPC分类号： A61K9/7084 ,  A61K9/7069 ,  A61K9/7092

    摘要： A diffusional drug delivery device is described which can provide for delayed onset of therapeutic effect and for delivery of the therapeutic agent in predetermined temporal patterns at optimum rates. Delay means are provided between the agent reservoir and the surface through which the agent is released by diffusion to delay the release of agent at a therapeutic rate for predetermined times after application. Suitable means include a delay membrane disposed between the releasing surface and the agent reservoir, which membrane is preferably free of undissolved agent and/or is initially impermeable to the agent and thereafter becomes permeable. One or more agent chambers defined by one or more of such membranes may be provided, whereby agents are released in predetermined temporal patterns at optimal release rates. Delayed permeability enables programmed washout periods to be obtained from the sequential and concurrent application of devices for the administration of drugs, such as nitrates, to which patients may develop a tolerance on continuous administration over extended time periods.

    摘要翻译： 描述了扩散药物递送装置，其可以提供治疗效果的延迟开始和以最佳速率以预定时间模式递送治疗剂。 在药剂储存器和通过扩散释放药剂的表面之间提供延迟装置，以在施用后以治疗速率延迟药剂释放预定时间。 合适的方法包括设置在释放表面和药剂储存器之间的延迟膜，该膜优选不含未溶解的试剂和/或最初不能渗透到试剂中，然后变得可渗透。 可以提供由一种或多种这样的膜限定的一个或多个试剂室，由此以最佳释放速率以预定的时间模式释放试剂。 延迟渗透性使得能够从连续和同时使用用于施用诸如硝酸盐的药物的装置获得程序性洗脱期，患者可以在延长的时间段内持续施用耐受性。

    Dosage form for administering drug of the colon
    19.
    发明授权
    Dosage form for administering drug of the colon 失效
    用于施用结肠的药物的剂型

    公开(公告)号：US4705515A

    公开(公告)日：1987-11-10

    申请号：US877048

    申请日：1986-06-23

    申请人： Patrick S. L. Wong ,  Felix Theeuwes

    发明人： Patrick S. L. Wong ,  Felix Theeuwes

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K9/24

    CPC分类号： A61K9/0004 ,  Y10T428/31884

    摘要： An osmotic device is disclosed for delivering a drug to the colon. The device comprises a laminated wall surrounding a compartment containing a drug with a passageway through the wall for dispensing the drug from the device. The laminated wall comprises three laminae, an inner semipermeable lamina, a middle lamina containing a salt of a fatty acid and an outer enteric lamina.

    摘要翻译： 公开了用于将药物递送至结肠的渗透装置。 该装置包括围绕包含药物的隔室的层压壁，该隔室具有通过壁的通道，用于从该装置分配药物。 层压壁包括三层，内半透膜，含有脂肪酸盐和外肠层的中间层。

    Prolonged release active agent dosage form adapted for gastric retention
    20.
    发明授权
    Prolonged release active agent dosage form adapted for gastric retention 失效
    延长释放活性剂剂型适合胃潴留

    公开(公告)号：US06548083B1

    公开(公告)日：2003-04-15

    申请号：US09615110

    申请日：2000-07-13

    申请人： Patrick S.-L. Wong ,  Liang-Chang Dong ,  David E. Edgren ,  Felix Theeuwes ,  Phyllis I. Gardner ,  Francisco Jao ,  Jason J. Wan

    发明人： Patrick S.-L. Wong ,  Liang-Chang Dong ,  David E. Edgren ,  Felix Theeuwes ,  Phyllis I. Gardner ,  Francisco Jao ,  Jason J. Wan

    IPC分类号： A61K922

    CPC分类号： A61K9/0065 ,  A61K9/2072

    摘要： The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of an active agent formulation to a fluid environment of use. The active agent dosage form is a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix is surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.

    摘要翻译： 本发明涉及一种活性剂剂型，其适于保留在胃中并且可用于将活性剂制剂延长递送至使用的流体环境。 活性剂剂型是与胃液接触时膨胀的聚合物基质。 聚合物基质的一部分由不溶性材料带包围，其阻止聚合物基质的被覆盖部分膨胀，并提供具有足够刚性以抵抗胃收缩和延迟排出的部分的剂型 剂型，直到基本上所有的活性剂已被分配。