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    Substituted Phenethylamines With Serotoninergic And/Or Norepinephrinergic Activity
    14.
    发明申请
    Substituted Phenethylamines With Serotoninergic And/Or Norepinephrinergic Activity 审中-公开

    公开(公告)号：US20200060995A1

    公开(公告)日：2020-02-27

    申请号：US16291126

    申请日：2019-03-04

    申请人： Auspex Pharmaceuticals, Inc.

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： A61K31/137 ,  C07C217/74 ,  C07C65/21 ,  C07C235/34 ,  C07C255/37 ,  A61K45/06 ,  C07B59/00

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY
    18.
    发明申请
    SUBSTITUTED PHENETHYLAMINES WITH SEROTONINERGIC AND/OR NOREPINEPHRINERGIC ACTIVITY 有权
    具有丝氨酸和/或非诺贝宁活性的取代的苯乙烯

    公开(公告)号：US20140296339A1

    公开(公告)日：2014-10-02

    申请号：US14306396

    申请日：2014-06-17

    申请人： Auspex Pharmaceuticals, Inc.

    发明人： Thomas G. Gant ,  Sepehr Sarshar

    IPC分类号： C07C65/21 ,  C07C217/74 ,  C07C255/37 ,  C07C235/34

    CPC分类号： A61K31/137 ,  A61K45/06 ,  C07B59/001 ,  C07B2200/05 ,  C07C65/21 ,  C07C217/74 ,  C07C235/34 ,  C07C255/37 ,  C07C2601/14

    摘要： Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.

    摘要翻译： 用于治疗和/或治疗精神病症，焦虑障碍，广泛性焦虑症，抑郁症，创伤后应激障碍，强迫症的单胺神经递质及其药学上可接受的盐和前药的新型抑制剂的化学合成和医学用途， 强迫症，恐慌症，热潮红，老年痴呆，偏头痛，肝肺综合征，慢性疼痛，伤害性疼痛，神经性疼痛，疼痛性糖尿病性视网膜病变，双相抑郁症，阻塞性睡眠呼吸暂停，精神疾病，经前焦虑症，社交恐惧症，社交焦虑症 ，尿失禁，厌食症，神经性贪食症，肥胖症，局部缺血，头部损伤，脑细胞中的钙超载，药物依赖性和/或早泄。