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11.发明申请Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals 有权具有生物异丝氨酸羧酸基团的环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US20040198786A1
公开(公告)日：2004-10-07
申请号：US10789865
申请日：2004-02-27
发明人： Dirk Gretzke , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： C07D263/02 , C07D413/02
CPC分类号： C07D417/12 , C07D263/32 , C07D413/12
摘要： Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals The invention relates to cycloalkyl derivatives having bioisosteric carboxylic acid groups and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula 1, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 具有生物硅烷酸羧酸基团的环烷基衍生物及其制备方法及其作为药物的用途本发明涉及具有生物硅烷酸羧酸基团的环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式1的化合物，其中基团如所定义，以及它们的生理上可接受的盐和它们的制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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12.发明申请Combination product of a 1,4-benzothiepine 1,1-dioxide compound with at least one other active ingredient and the use of the product 有权1,4-苯并噻吩1,1-二氧化物化合物与至少一种其它活性成分的组合产物和产物的用途公开(公告)号：US20040097424A1
公开(公告)日：2004-05-20
申请号：US10699967
申请日：2003-11-03
IPC分类号： A61K038/06 , A61K038/05 , A61K038/04 , A61K031/7048 , C07K005/06 , C07K005/04
CPC分类号： A61K45/06 , A61K31/395 , A61K31/55 , A61K2300/00
摘要： The present invention is directed to a 1,4-benzothiepine 1,1-dioxide compound of formula I 1 in which the radicals have the meanings defined herein, or a pharmaceutically acceptable salt or physiologically functional derivative thereof, with at least one other active ingredient, or a pharmaceutically acceptable salt or physiologically functional derivative thereof. The invention is also directed to the use of the combination product, pharmaceutical composition comprising the combination product and method for preparing the pharmaceutical composition.
摘要翻译： 本发明涉及其中基团具有本文定义的含义，或其药学上可接受的盐或生理功能衍生物的式I的1,4-苯并硫代1,1-二氧化物化合物与至少一种其它活性成分， 或其药学上可接受的盐或生理功能衍生物。 本发明还涉及组合产品，包含组合产品和方法的药物组合物用于制备药物组合物的用途。
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