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1.发明申请Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20040220261A1
公开(公告)日：2004-11-04
申请号：US10789324
申请日：2004-02-27
发明人： Christian Stapper , Heiner Glombik , Eugen Falk , Dirk Gretzke , Jochen Goerlitzer , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K031/445 , A61K031/24 , A61K031/215
CPC分类号： C07C275/28 , C07C275/10 , C07C275/24 , C07C275/26 , C07C2601/14
摘要： The invention relates to arylcycloalkyl-substituted derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
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2.发明申请1,3-substitued cycloalkyl derivatives having acidic, mostly heterocyclic groups; processes for their preparation and their use as pharmaceuticals 审中-公开具有酸性，主要是杂环基团的1,3-取代的环烷基衍生物; 其制备方法及其作为药物的用途公开(公告)号：US20040209932A1
公开(公告)日：2004-10-21
申请号：US10789281
申请日：2004-02-27
发明人： Jochen Goerlitzer , Heiner Glombik , Eugen Falk , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： C07D263/02 , A61K031/421
CPC分类号： C07D263/32 , C07D413/12 , C07D471/04 , C07F5/025
摘要： The invention relates to 1,3-substituted cycloalkyl derivatives having acidic, mostly heterocyclic groups and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 本发明涉及具有酸性，主要是杂环基团的1,3-取代的环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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公开(公告)号：US20030017996A1
公开(公告)日：2003-01-23
申请号：US10201050
申请日：2002-07-24
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K031/7042
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: 1 in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
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4.发明申请Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals 有权芳基环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途公开(公告)号：US20040209920A1
公开(公告)日：2004-10-21
申请号：US10789017
申请日：2004-02-27
发明人： Christian Stapper , Stefanie Keil , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： A61K031/4439 , A61K031/422 , C07D413/02
CPC分类号： C07D263/32 , C07D413/02
摘要： Arylcycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl-substituted alkanoic acid derivatives and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable, for example, for the treatment and/or prevention of disorders of the fatty acid metabolism and glucose utilization disorders and also disorders in which insulin resistance is involved.
摘要翻译： 芳基环烷基取代的链烷酸衍生物，其制备方法及其作为药物的用途本发明涉及芳基环烷基取代的链烷酸衍生物及其生理上可接受的盐和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 该化合物例如适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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5.发明申请Methods of treatment with combinations of statin and aryl-substituted propanolamine derivatives 有权用他汀类药物和芳基取代的丙醇胺衍生物联合治疗的方法公开(公告)号：US20030195145A1
公开(公告)日：2003-10-16
申请号：US10351317
申请日：2003-01-27
IPC分类号： A61K038/14 , C07K009/00 , A61K031/7052 , C07H017/02
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I 1 in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译： 描述了取代的丙醇胺衍生物，其药学上可耐受的盐及其生理功能衍生物。 还描述了其中基团具有上述含义的式I化合物及其生理上耐受的盐，生理功能衍生物及其制备方法。 该化合物适合作为例如降血脂药。
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6.发明申请Combinations with statin and aryl-substituted propanolamine derivatives, their preparation, pharmaceuticals comprising them, and their use 有权与他汀类和芳基取代的丙醇胺衍生物的组合，它们的制备，包含它们的药物及其用途公开(公告)号：US20020177610A1
公开(公告)日：2002-11-28
申请号：US09985149
申请日：2001-11-01
IPC分类号： C07D41/14 , C07D41/02 , A61K031/444
CPC分类号： C07H15/18
摘要： Substituted propanolamine derivatives, their pharmaceutically tolerated salts and physiologically functional derivatives thereof are described. Also described are compounds of formula I 1 in which the radicals have the abovementioned meanings, and their physiologically tolerated salts, physiologically functional derivates and processes for their preparation. The compounds are suitable as, for example, hypolipidemics.
摘要翻译： 描述了取代的丙醇胺衍生物，其药学上可耐受的盐及其生理功能衍生物。 还描述了其中基团具有上述含义的式I化合物及其生理上耐受的盐，生理功能衍生物及其制备方法。 该化合物适合作为例如降血脂药。
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7.发明申请Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals 有权具有支链侧链的芳基环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US20040209873A1
公开(公告)日：2004-10-21
申请号：US10789323
申请日：2004-02-27
发明人： Christian Stapper , Heiner Glombik , Eugen Falk , Jochen Goerlitzer , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Wolfgang Wendler
IPC分类号： C07D279/12 , C07D211/06 , A61K031/54 , A61K031/537 , A61K031/495
CPC分类号： C07D213/40 , C07C275/10 , C07C275/24 , C07C275/26 , C07C275/28 , C07C275/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D295/13
摘要： Arylcycloalkyl derivatives having branched side chains, processes for their preparation and their use as pharmaceuticals The invention relates to arylcycloalkyl derivatives having branched side chains and to their physiologically acceptable salts and physiologically functional derivatives. What is described are compounds of the formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 具有支链侧链的芳基环烷基衍生物及其制备方法及其作为药物的用途本发明涉及具有支链侧链的芳基环烷基衍生物及其生理上可接受的盐和生理功能衍生物。 所描述的是式I化合物，其中自由基如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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8.发明申请Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticals 有权二芳基环烷基衍生物，其制备方法及其作为药物的用途公开(公告)号：US20040204462A1
公开(公告)日：2004-10-14
申请号：US10789019
申请日：2004-02-27
发明人： Jochen Goerlitzer , Heiner Glombik , Eugen Falk , Dirk Gretzke , Stefanie Keil , Hans-Ludwig Schaefer , Christian Stapper , Wolfgang Wendler
IPC分类号： C07D263/02 , A61K031/421
CPC分类号： C07D263/32
摘要： Diarylcycloalkyl derivatives, process for their preparation and their use as pharmaceuticals The invention relates to diarylcycloalkyl derivatives and to their physiologically acceptable salts, racemates and physiologically functional derivatives. What is described are compounds of the formula I, 1 in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparation. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistence is involved.
摘要翻译： 二芳基环烷基衍生物，其制备方法及其作为药物的用途本发明涉及二芳基环烷基衍生物及其生理学上可接受的盐，外消旋体和生理功能衍生物。 描述的是式I化合物，其中基团如所定义，以及它们的生理上可接受的盐及其制备方法。 所述化合物适用于治疗和/或预防脂肪酸代谢紊乱和葡萄糖利用障碍以及涉及胰岛素抵抗的疾病。
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9.发明申请Benzothiepine 1, 1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use 有权苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途公开(公告)号：US20040087648A1
公开(公告)日：2004-05-06
申请号：US10606771
申请日：2003-06-27
发明人： Wendelin Frick , Alfons Enhsen , Heiner Glombik , Hubert Heuer
IPC分类号： A61K031/38
CPC分类号： C07K5/06086 , A61K38/00 , C07D337/08 , C08G65/329
摘要： Substituted benzothiepine 1,1-dioxide derivatives of formula I: 1 in which R1, R2, R3, R4, R5 and Z have the meanings indicated, and their physiologically tolerable salts and physiologically functional derivatives and a process for their preparation are described. The compounds are suitable, for example, as hypolipidemics.
摘要翻译： 取代的式I的苯并噻吩1,1-二氧化物衍生物：其中R 1，R 2，R 3，R 4，R 5和Z具有所示的含义，并且其生理上可耐受的盐 和生理功能衍生物及其制备方法。 该化合物例如可用作降血脂药物。
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10.发明申请Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof 审中-公开新型杂环核苷酸衍生物，含有这些化合物的药物及其用途公开(公告)号：US20040259819A1
公开(公告)日：2004-12-23
申请号：US10734573
申请日：2003-12-12
发明人： Wendelin Frick , Heiner Glombik , Werner Kramer , Hubert Heuer , Harm Brummerhop , Oliver Plettenburg
IPC分类号： A61K031/7056 , C07H019/056
摘要： Novel heterocyclic fluoroglycoside derivatives, medicaments containing these compounds, and the use thereof. The invention relates to substituted heterocyclic fluoroglycoside derivatives of the formula I 1 in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation. The compounds are suitable for example as antidiabetics.
摘要翻译： 新型杂环核苷酸衍生物，含有这些化合物的药物及其用途。 本发明涉及其中基团具有所述含义的式I的取代的杂环氟代果糖衍生物及其生理上耐受的盐及其制备方法。 该化合物适合于例如抗糖尿病药。
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