公开(公告)号：US3908008A

公开(公告)日：1975-09-23

申请号：US28344272

申请日：1972-08-24

Applicant: BAYER AG

Inventor： LEY KURT ,  EHOLZER ULRICH ,  NAST ROLAND ,  METZGER KARL GEORG ,  FRITSCHE DIETER

IPC: C07D241/52 ,  A61K27/00

CPC classification number: C07D241/52

Abstract: Pharmaceutical compositions comprising 2-methyl-3-carboxylic acid-amido-quinoxaline-1,4-di-N-oxides of the formula

wherein: R1 is hydrogen, lower alkyl, lower alkoxy or chlorine, R2 is hydrogen, straight or branched chain alkyl or straight or branched chain alkyl substituted by hydroxy, lower alkoxy, carbalkoxy, monoalkylamino or dialkylamino, and R3 is straight or branched chain alkyl, straight or branched chain alkyl substituted by hydroxy, lower alkoxy, carbalkoxy, monoalkylamino or dialkylamino, or when R2 is hydrogen, cyclohexyl, or R2 and R3 together with the amido nitrogen atom form part of a 5- or 6- membered heterocyclic ring, IN COMBINATION WITH A PHARMACEUTICALLY ACCEPTABLE INERT CARRIER ARE USEFUL FOR THEIR ANTIBACTERIAL EFFECT. These compositions or their active compounds can be administered subcutaneously or orally to humans or animals.

Abstract translation: 包含式OR2的化合物的2-甲基-3-羧酸 - 酰氨基 - 喹喔啉-1,4-二-N-氧化物的药物组合物，其中：

公开(公告)号：US3697433A

公开(公告)日：1972-10-10

申请号：US3697433D

申请日：1970-12-21

Applicant: BAYER AG

Inventor： SCHUBART RUDIGER ,  EHOLZER ULRICH ,  KEMPERMANN THEO ,  ROOS ERNST

IPC: C07F9/165 ,  C08K5/5398 ,  C08C11/66 ,  C08D13/28

CPC classification number: C07F9/1656 ,  C07F9/1652 ,  C08K5/5398 ,  C08L23/16

Abstract: VULCANIZATION ACCELERATORS BASED ON S,S''-CARBONYL-BISDIALKYLDITHIOPHOSPHATES AND A THIAZOLE ACCELERATOR WITH THE OPTIONAL INCLUSION OF THIURAMIC OR DITHIOCARBAMATE ACCELERATORS AND/OR THIOUREA, PROCESS OF VULCANZING TERPOLYMERS OF ETHYLENE AND PROPYLENE, I.E., EPDM RUBBERS, AND RESULTING PRODUCT.

公开(公告)号：US3598820A

公开(公告)日：1971-08-10

申请号：US3598820D

申请日：1968-10-02

Applicant: BAYER AG

Inventor： LEY KURT ,  EHOLZER ULRICH ,  NAST ROLAND ,  METZGER KARL-GEORG ,  FRITSCHE DIETER

IPC: C07D241/52 ,  C07D51/78

CPC classification number: C07D241/52

Abstract: 2-ISOTHIOURONIUM-METHYL-3-CARBOXYLIC ACID-AMIDO-QUINOXALINE-1,4-DI-N-OXIDE HALIDES OF THE FORMULA:

(R1-,1,4-DI-O-,2-R2-N(-R3)-CO-,3-H2N-C(=NH2(+))-S-CH2-

QUINAZOLINE)(+) HAL(-) (I)

WHEREIN

R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR CHLORINE, R2 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL OR STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, R3 IS HYDROGEN, STRAIGHT OR BRANCHED CHAIN ALKYL, STRAIGHT OR BRANCHED CHAIN ALKYL SUBSTITUTED BY HYDROXY, LOWER ALKOXY, ACYLOXY, MONOALKYLAMINO OR DIALKYLAMINO, OR WHEN R2 IS HYDROGEN, CYCLOHEXYL, OR R2 AND R3 TOGETHER WITH THE AMIDE NITROGEN ATOM FORM PART OF A 5- OR 6-MENBERED HETEROCYCLIC RING, AND HAL IS CHLORINE OR BROMINE,

ARE USEFUL FOR THEIR ANTIBACTERIAL EFFECT. THESE COMPOUNDS MAY BE PRODUCED, INTER ALIA, BY REACTING A 2-HALOMETHYL3-CARBOXYLIC ACID AMIDO-QUIOXALINE-1,4-DI-N-OXIDE OF THE FORMULA:

R1-,1,4-DI-O
WITH THIOUREA, WHEREIN R1, R2, R3 AND HAL ARE AS ABOVE DEFINED.

Abstract translation: 2-异硫脲鎓 - 甲基-3-羧酸 - 酰氨基喹喔啉-1,4-二-N-氧化物的下式：

公开(公告)号：US3555025A

公开(公告)日：1971-01-12

申请号：US3555025D

申请日：1968-10-02

Applicant: BAYER AG

Inventor： LEY KURT ,  EHOLZER ULRICH ,  METZGER KARL-GEORG ,  FRITSCHE DIETER

IPC: C07D241/52 ,  C07D51/76

CPC classification number: C07D241/52

Abstract: 2-METHYL-3-AMIDINO-QUINOXALINE-1,4-DI-N-OXIDES OF THE FORMULA:

2-(R2-NH-C(=NH)-),3-CH3,R1-QUINOXALINE 1,4-DIOXIDE

WHEREIN:

R1 IS HYDROGEN, LOWER ALKYL, LOWER ALKOXY OR CHLORINE, AND R2 IS HYDROXY OR AMINO,

ARE USEFUL AS ANTIBACTERIAL COMPOUNDS. THESE COMPOUNDS MAY BE PRODUCED, INTER ALIA, BY REACTING A 2-METHYL-3CYANO-QUINOXALINE-1,4-DI-N-OXIDE OF THE FORMULA:

2-(NC-),3-CH3,R1-QUINOXALINE 1,4-DIOXIDE

WITH A COMPOUND OF THE FORMULA:

R2-NH2

WHEREIN R1 AND R2 ARE AS ABOVE DEFINED.