公开(公告)号：US11897898B2

公开(公告)日：2024-02-13

申请号：US17265986

申请日：2019-08-13

Applicant: BIOGEN MA INC.

Inventor： Felix Gonzalez Lopez de Turiso

IPC: C07D498/22 ,  A61K31/4741 ,  C07D519/00

CPC classification number: C07D498/22 ,  C07D519/00

Abstract: Provided are compounds of Formula (I′), including compounds of Formulas (I), (II), (III), (IIIA) and (IIIB), wherein L, R1, R3 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).

公开(公告)号：US20210317103A1

公开(公告)日：2021-10-14

申请号：US17267631

申请日：2019-08-13

Applicant: BIOGEN MA INC.

Inventor： Felix Gonzalez Lopez de Turiso ,  Zhili Xin ,  Martin Himmelbauer ,  John H. Jones

IPC: C07D401/14 ,  C07D405/14

Abstract: Provided are compounds of Formula (I): Formula (I), including compounds of Formulas (II), (III), (IV), (V) and (VI), wherein X, R1, R2, R3, R4 and n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).