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公开(公告)号：US20250002600A1
公开(公告)日：2025-01-02
申请号：US18696689
申请日：2022-10-05
Applicant: Genmab A/S , BioNTech SE
Inventor： Alexander MUIK , Kristina SCHÖDEL , Nora PENCHEVA , Maria N. JURE-KUNKEL , Ugur SAHIN , Sina FELLERMEIER-KOPF , Patricia GARRIDO CASTRO , Jordan BLUM , Friederike GIESEKE , Esther C. W. BREIJ , Lars GUELEN , Joost NEIJSSEN , Karsten BECKMANN , Claudia PAULMANN , Bart-Jan DE KREUK , Richard G. HIBBERT , Janine SCHUURMAN , Aran LABRIJN , Ivan KUZMANOV
Abstract: The present invention provides combination therapy using a binding agent that binds to human CD137 and to human PD-L1 in combination with a PD-1 inhibitor to reduce or prevent progression of a tumor or treating cancer.
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公开(公告)号：US20230089969A1
公开(公告)日：2023-03-23
申请号：US17817033
申请日：2022-08-03
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US20230087745A1
公开(公告)日：2023-03-23
申请号：US17821837
申请日：2022-08-24
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK , Christian GRUNWITZ , Edward VAN DEN BRINK , Dennis VERZIJL
IPC: C07K16/28
Abstract: The present invention relates to novel binding agents and their use in medicine. In particular, the invention relates to binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the antibodies of the invention and to methods, nucleic acid constructs and host cells for producing antibodies of the invention.
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公开(公告)号：US20230087164A1
公开(公告)日：2023-03-23
申请号：US17795318
申请日：2021-02-04
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Ugur SAHIN , Alexander MUIK , Isil ALTINTAS , Ulf FORSSMANN , Kate SASSER , Maria JURE-KUNKEL , Manish GUPTA
Abstract: The present invention relates to a method for reducing or preventing progression of a tumor or treating cancer. The method comprises administering to a subject, a binding agent comprising a first binding region binding to human CD137 and a second binding region binding to human PD-L1. The amount of binding agent administered in each treatment cycle is preferably about 0.3-5 mg/kg body weight or about 25-400 mg in total.
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公开(公告)号：US20220033510A1
公开(公告)日：2022-02-03
申请号：US17360438
申请日：2021-06-28
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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Patent Agency Ranking
公开(公告)号：US20210369842A1
公开(公告)日：2021-12-02
申请号：US17289602
申请日：2019-11-06
Applicant: GENMAB A/S , BIONTECH SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Ugur SAHIN , Friederike GIESEKE , Alexander MUIK
Abstract: The present invention relates to pharmaceutical formulations of binding agents and their use in medicine. In particular, the invention relates to pharmaceutical formulations of binding agents such as bispecific antibodies binding human PD-L1 and binding human CD137. The invention furthermore relates to uses of the pharmaceutical formulations of the invention and to methods for producing pharmaceutical formulations.
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公开(公告)号：US20240262924A1
公开(公告)日：2024-08-08
申请号：US18570257
申请日：2022-06-20
Applicant: GENMAB A/S , BioNTech SE
Inventor： Ugur SAHIN , Alexander MUIK , Ulf FORSSMANN , Maria N. JURE-KUNKEL , Gaurav BAJAJ , Craig THALHAUSER , Nora PENCHEVA
CPC classification number: C07K16/2878 , A61P35/00 , C07K16/2827 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/31
Abstract: The present invention relates to a method for reducing or preventing progression of a tumor or treating cancer in a subject, comprising administering to the subject a binding agent comprising a first antigen-binding region binding to human CD137, and a second antigen-binding region binding to human PD-L1. The invention further provides a binding agent for use in reducing or preventing progression of a tumor or for use in treatment of cancer.
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公开(公告)号：US20230295335A1
公开(公告)日：2023-09-21
申请号：US18184120
申请日：2023-03-15
Applicant: Genmab A/S , BioNTech SE
Inventor： Andreea IOAN , Esther Cornelia Wilhelmina BREIJ , Lars GUELEN , David P.E. SATIJN , Ugur SAHIN , Alexander MUIK , Kristina SCHÖDEL , Sina FELLERMEIER-KOPF , Bart-Jan DE KREUK , Richard HIBBERT , Janine SCHUURMAN , Aran Frank LABRIJN
CPC classification number: C07K16/30 , C07K16/2878 , C07K2317/31 , C07K2317/92
Abstract: The present invention provides a binding agent that binds to EpCAM and to CD137 which is useful to treat or prevent a tumor or cancer, or to prevent progression of a tumor or cancer.
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公开(公告)号：US20220064317A1
公开(公告)日：2022-03-03
申请号：US17360437
申请日：2021-06-28
Applicant: GENMAB A/S , BioNTech SE
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , A61K39/395 , G01N33/569
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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公开(公告)号：US20200062853A1
公开(公告)日：2020-02-27
申请号：US16316534
申请日：2017-07-14
Applicant: GENMAB A/S , BIONTECH AG
Inventor： Isil ALTINTAS , David SATIJN , Rik RADEMAKER , Paul PARREN , Friederike GIESEKE , Ugur SAHIN
IPC: C07K16/28 , G01N33/569 , A61K39/395
Abstract: Multispecific antibodies binding to human CD40 and human CD137, methods for preparing such multispecific antibodies, and methods of using such multispecific antibodies for therapeutic or other purposes.
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