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公开(公告)号:US20250002600A1
公开(公告)日:2025-01-02
申请号:US18696689
申请日:2022-10-05
Applicant: Genmab A/S , BioNTech SE
Inventor: Alexander MUIK , Kristina SCHÖDEL , Nora PENCHEVA , Maria N. JURE-KUNKEL , Ugur SAHIN , Sina FELLERMEIER-KOPF , Patricia GARRIDO CASTRO , Jordan BLUM , Friederike GIESEKE , Esther C. W. BREIJ , Lars GUELEN , Joost NEIJSSEN , Karsten BECKMANN , Claudia PAULMANN , Bart-Jan DE KREUK , Richard G. HIBBERT , Janine SCHUURMAN , Aran LABRIJN , Ivan KUZMANOV
Abstract: The present invention provides combination therapy using a binding agent that binds to human CD137 and to human PD-L1 in combination with a PD-1 inhibitor to reduce or prevent progression of a tumor or treating cancer.