公开(公告)号：US20250002600A1

公开(公告)日：2025-01-02

申请号：US18696689

申请日：2022-10-05

Applicant: Genmab A/S ,  BioNTech SE

Inventor： Alexander MUIK ,  Kristina SCHÖDEL ,  Nora PENCHEVA ,  Maria N. JURE-KUNKEL ,  Ugur SAHIN ,  Sina FELLERMEIER-KOPF ,  Patricia GARRIDO CASTRO ,  Jordan BLUM ,  Friederike GIESEKE ,  Esther C. W. BREIJ ,  Lars GUELEN ,  Joost NEIJSSEN ,  Karsten BECKMANN ,  Claudia PAULMANN ,  Bart-Jan DE KREUK ,  Richard G. HIBBERT ,  Janine SCHUURMAN ,  Aran LABRIJN ,  Ivan KUZMANOV

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/00 ,  A61P35/00

Abstract: The present invention provides combination therapy using a binding agent that binds to human CD137 and to human PD-L1 in combination with a PD-1 inhibitor to reduce or prevent progression of a tumor or treating cancer.