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公开(公告)号：US20220163516A1
公开(公告)日：2022-05-26
申请号：US17355338
申请日：2021-06-23
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Haonan LIU , Yudan YIN , Ding DING
IPC: G01N33/543 , B01L3/00
Abstract: The present disclosure provides a digital immunochip and a manufacture method thereof. The digital immunochip includes a first substrate and a second substrate which are opposite to each other. The first substrate includes: a first base substrate; at least one driving electrode on the first base substrate and configured to drive an object to be detected to move; a dielectric layer on a side of the at least one driving electrode away from the first base substrate and covering the at least one driving electrode; and a first hydrophobic layer on a side of the dielectric layer away from the first base substrate. The second substrate includes: a second base substrate; and an immunoassay substance on a side of the second base substrate proximal to the first hydrophobic layer of the first substrate and including an antigen or an antibody.
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公开(公告)号：US20200261912A1
公开(公告)日：2020-08-20
申请号：US16645535
申请日：2019-08-07
Applicant: BOE Technology Group Co., Ltd.
Inventor： Yudan YIN
Abstract: A method for generating micro samples and a generation chip. The method includes: simultaneously adding polyelectrolyte solutions with opposite charges respectively at a set flow rate to at least one pair of liquid inlet holes of pretreated generation chip of micro samples; wherein proportions of positive charges and negative charges of the polyelectrolyte solutions added to the pair of liquid inlet holes are substantively same; respectively controlling sample inlet channels through which the polyelectrolyte solutions in the liquid inlet holes enter the generation chip to be communicated with the liquid inlet holes; and controlling convergence of the polyelectrolyte solutions entering the sample inlet channels in a main channel of the generation chip, and forming in situ micro samples of a compound with a set diameter in the main channel within a set recombination time.
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Patent Agency Ranking
公开(公告)号：US20230191394A1
公开(公告)日：2023-06-22
申请号：US18112671
申请日：2023-02-22
Inventor： Zhihong WU , Zijian ZHAO , Yudan YIN , Mengjun HOU , Kang PENG
IPC: B01L3/00
CPC classification number: B01L3/5023 , B01L2300/0645 , B01L2300/1811 , C12Q1/686
Abstract: A detection chip, a using method for the same, and a reaction system. The detection chip includes a first substrate, a micro-cavity defining layer, and a heating electrode. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is on the first substrate and is closer to the first substrate than the micro-cavity defining layer, and is configured to heat a plurality of micro-reaction chambers. The orthographic projection of the plurality of micro-reaction chambers on the first substrate is within the orthographic projection of the heating electrode on the first substrate.
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公开(公告)号：US20230137571A1
公开(公告)日：2023-05-04
申请号：US17606695
申请日：2021-02-05
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Haonan LIU , Yudan YIN , Ding DING
Abstract: The present disclosure relates to a microfluidic chip. The microfluidic chip includes a first substrate, and the first substrate includes a sample input hole and a reaction region located downstream of the sample input hole. The reaction region includes at least one groove, an orthographic projection of each groove on the first substrate is an axisymmetric pattern, a width of the axisymmetric pattern in a first direction is not less than a width of the axisymmetric pattern in a second direction, and the first direction is perpendicular to the second direction.
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公开(公告)号：US20210354141A1
公开(公告)日：2021-11-18
申请号：US16624813
申请日：2019-03-12
Applicant: BOE TECHNOLOGY GROUP CO., LTD.
Inventor： Zhihong WU , Defeng MAO , Zijian ZHAO , Yudan YIN
Abstract: A microfluidic particle sorting apparatus for capturing targets from fluid containing the targets is disclosed. The apparatus includes an inlet for receiving the fluid; a sorting chamber allowing the fluid to flow through; a first outlet for discharging the fluid after flowing through the sorting chamber; a capturing structure for capturing the cells, wherein the capturing structure is upstream of the first outlet, and includes obstacles in an array, each extending through the sorting chamber in a lateral direction with respect to a fluid flow of the fluid; and a second outlet upstream of the capturing structure comprising a plurality of openings; wherein a gap between two adjacent obstacles is equal to or greater than each opening of the second outlet.
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公开(公告)号：US20210237052A1
公开(公告)日：2021-08-05
申请号：US16634309
申请日：2019-03-29
Inventor： Zhihong WU , Zijian ZHAO , Yudan YIN , Mengjun HOU , Kang PENG
IPC: B01L3/00
Abstract: A detection chip, a using method for the same, and a reaction system. The detection chip includes a first substrate, a micro-cavity defining layer, and a heating electrode. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. The heating electrode is on the first substrate and is closer to the first substrate than the micro-cavity defining layer, and is configured to heat a plurality of micro-reaction chambers. The orthographic projection of the plurality of micro-reaction chambers on the first substrate is within the orthographic projection of the heating electrode on the first substrate.
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公开(公告)号：US20210229103A1
公开(公告)日：2021-07-29
申请号：US16753115
申请日：2019-03-29
Inventor： Zijian ZHAO , Siyi YIN , Yudan YIN
Abstract: A detection chip, a method for operating a detection chip, and a reaction system are disclosed. The detection chip includes a first substrate, a micro-cavity defining layer, a hydrophilic layer, and a hydrophobic layer. The micro-cavity defining layer is on the first substrate and defines a plurality of micro-reaction chambers. Each of the plurality of micro-reaction chambers includes a reaction trap, and the reaction trap includes a sidewall and a bottom. The micro-cavity defining layer includes a spacing region between the plurality of micro-reaction chambers, and the spacing region includes a first region adjacent to the sidewall, and a second region non-adjacent to the sidewall. The hydrophilic layer covers the sidewall and the bottom of each of the plurality of micro-reaction chambers, and the hydrophobic layer covers the second region.
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