公开(公告)号：US20150225452A1

公开(公告)日：2015-08-13

申请号：US14419975

申请日：2013-08-06

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Robert M. Borzilleri ,  Heidi L. Perez ,  Donna D. Wei ,  Kyoung S. Kim

IPC: C07K5/09 ,  A61K45/06 ,  A61K38/06

CPC classification number: C07K5/0815 ,  A61K38/06 ,  A61K45/06 ,  C07D207/16 ,  C07D401/12 ,  C07K5/06026 ,  C07K5/0806

Abstract: There are disclosed compounds of formula (I) that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing said compounds.

Abstract translation: 公开了利用所述化合物调节凋亡抑制剂（IAP）的活性的式（I）化合物，含有所述化合物的药物组合物和治疗增殖性疾病的方法和失调性凋亡障碍（例如癌症）的化合物。