公开(公告)号：US20180023081A1

公开(公告)日：2018-01-25

申请号：US15548391

申请日：2016-02-04

Applicant: Bristol-Myers Squibb Company ,  Roche Innovation Center Copenhagen A/S

Inventor： Peter HAGEDORN ,  Richard E. OLSON ,  Anja Mølhart HØG ,  Marianne Lerbech JENSEN ,  Dong LI ,  Niels Fisker NIELSEN

IPC: C12N15/113

CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/343 ,  C12N2310/346 ,  C12N2310/351

Abstract: The present invention relates to LNA oligomers having two flanks, wherein one or both flanks comprise alternating LNA and DNA nucleosides.

公开(公告)号：US20170137425A1

公开(公告)日：2017-05-18

申请号：US15317546

申请日：2015-06-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ivar M. MCDONALD ,  F. Christopher ZUSI ,  Richard E. OLSON

IPC: C07D471/18

CPC classification number: C07D471/18

Abstract: The disclosure provides compounds of formula I including their salts, as well as compositions and methods of using the compounds. The compounds are ligands for the nicotinic 7 receptor and may be useful for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.